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Drug-Target Interaction

Drug

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PubChem ID:4781
Structure:
Synonyms:
"pirarreumol ""b"""
'Esteve'
1,2-Diphenyl-2,3-dioxo-4-N-butylpyrazoline
1,2-Diphenyl-3,5-dioxo-4-butylpyrazolidine
1,2-diphenyl-3,5-dioxo-4-n-butylpyrazoline
1,2-Diphenyl-4-butyl-3,5-dioxopyrazolidine
1,2-Diphenyl-4-butyl-3,5-pyrazolidinedione
3,5-Dioxe-4 buty-1, diphenyl-pyrazolidine
3,5-Dioxo-1,2-diphenyl-4-N-butyl-pyrazolidin
3,5-Dioxo-1,2-diphenyl-4-N-butylpyrazolidine
3,5-dioxo-4-butyl-1-diphenyl-pyrazolidine
3,5-Pyrazolidinedione, 4-butyl-1,2-diphenyl-
4-Butyl-1,2 -diphenyl-3,5-dioxo pyrazolidine
4-butyl-1,2-di(phenyl)pyrazolidine-3,5-dione
4-butyl-1,2-diphenyl-1,2-diazolidine-3,5-dione
4-Butyl-1,2-diphenyl-3,5-dioxo pyrazolidine
4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidine
4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione
4-BUTYL-1,2-DIPHENYL-PYRAZOLIDINE-3,5-DIONE
4-Butyl-1,2-diphenylpyrazolidine-3,5-dione
4-n-Butyl-1,2-diphenyl-3,5-pyrazolidinedione
4297-92-1
5-24-05-00400 (Beilstein Handbook Reference)
50-33-9
A 7514
AC-683
AC1L1IXW
AC1Q2VLE
AKOS001592731
Alindor
Alka Butazolidin
Alkabutazona
Alqoverin
Anerval
Anpuzone
Antadol
Anuspiramin
Apo-Phenylbutazone
art rizin
Arthrizon
Artizin
Artrizin
Artrizone
Artropan
Azdid
Azobutyl
Azolid
Azolid (TN)
B.T.Z
B.t.z.
Benzone
Betazed
Bio-0693
Bizolin
Bizolin 200
BRN 0290080
BSPBio_002369
Bunetzone
Busone
Buta phen
Butacompren
Butacote
Butadion
Butadiona
Butadione
Butadionum
Butagesic
Butalan
Butalgina
Butalidon
Butaluy
Butaphen
Butapirazol
Butapirazole
Butapyrazole
Butarecbon
Butartril
Butartrina
Butatab
Butatron
Butazina
Butazolidin
Butazolidine
Butazona
Butazone
Bute
Bute, Butazolidin, Butatron, Phenylbutazone
Butidiona
Butiwas-Simple
Butone
Butoz
butyl pyrin
Butylpyrin
Buvetzone
Buzon
C07440
C19H20N2O2
CCG-39220
CCRIS 2374
CHEBI:48574
CHEMBL101
Chembutazone
component of Azolid-A
Cotylbutazone
D00510
D010653
DA-192
DB00812
DB08343
Digibutina
Diossidone
Diozol
Diphebuzol
Diphenylbutazone
DivK1c_000331
Ecobutazone
EINECS 200-029-0
Elmedal
Equi bute
Equipalazone
Equiphen
Eributazone
esteve
EU-0100993
Exrheudon N
FBZ
fe nilbutine
Febuzina
Fenartil
Fenibutal
Fenibutasan
Fenibutazona
Fenibutol
Fenilbutazon
Fenilbutazona
Fenilbutazona [INN-Spanish]
Fenilbutazone
Fenilbutazone [DCIT]
Fenilbutina
Fenilbutine
Fenilidina
Fenotone
Fenylbutazon
Flexazone
G 13,871
G 13871
HMS1920H06
HMS2090H17
HMS2091P08
HMS2233B13
HMS3263G07
HMS501A13
HSDB 3159
I01-0883
Ia-But
IDI1_000331
Intalbut
Intrabutazone
Intrazone
Ipsoflame
Kadol
KBio1_000331
KBio2_001559
KBio2_004127
KBio2_006695
KBio3_001589
KBioGR_000954
KBioSS_001559
Lingel
Lopac-P-8386
Lopac0_000993
LS-71
Malgesic
Mepha-Butazon
Mephabutazon
Mephabutazone
Merizone
MLS000069424
MLS001148412
MLS002152929
Nadazone
Nadozone
NCGC00015846-01
NCGC00015846-02
NCGC00015846-03
NCGC00015846-04
NCGC00015846-05
NCGC00015846-06
NCGC00015846-07
NCGC00015846-08
NCGC00015846-09
NCGC00015846-10
NCGC00015846-11
NCGC00015846-12
NCGC00015846-13
NCGC00023855-03
NCGC00023855-04
NCGC00023855-05
NCGC00023855-06
NCGC00023855-07
NCGC00023855-08
NCGC00181112-01
nchembio.128-comp31
NCI-C55414
NCI-C56531
Neo-zoline
NINDS_000331
Novophenyl
NSC 25134
NSC25134
Oprea1_416494
P 8386
P1686
P1Z
P8386_SIGMA
PBZ
Phebuzin
Phebuzine
Phen-Buta-Vet
Phenbutazol
Phenbutazone
Phenopyrine
Phenyl butazone
Phenyl-Mobuzon
Phenylbutaz
Phenylbutazon
Phenylbutazon [German]
Phenylbutazone
Phenylbutazone (JP15/USP/INN)
Phenylbutazone (JP16/USP/INN)
Phenylbutazone [BAN:INN:JAN]
Phenylbutazone [USAN:INN:BAN:JAN]
Phenylbutazone [USAN]
Phenylbutazone-Supplied by Selleck Chemicals
Phenylbutazonum
Phenylbutazonum [INN-Latin]
Phenyzene
Phenyzone
Pirarreumol "B"
Pirarreumol B
Praecirheumin
Pyrabutol
Pyrazolidin
R-3-ZON
Rectofasa
Reudo
Reudox
Reumasyl
Reumazin
Reumazol
Reumune
Reumuzol
Reupolar
Robizon-V
Robizone
Robizone-V
Rubatone
S1654_Selleck
SBB012526
Scanbutazone
Schemergen
Schemergin
Shigrodin
SMR000059073
SPBio_001283
SPECTRUM1500482
Spectrum2_001282
Spectrum3_000675
Spectrum4_000477
Spectrum5_001335
Spectrum_001079
SR-01000000004-4
ST066897
STK388348
Tazone
Tencodyne
Tetnor
Tevcodyne
Therazone
Ticinil
Todalgil
UNII-GN5P7K3T8S
UNM000001255503
Usaf ge-15
Uzone
VAC-10
Wescozone
WLN: T5VNNV EHJ BR& CR& E4
Zolaphen
Zolidinum
Zorane
ATC-Codes:

Target

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Uniprot ID:CP2C9_HUMAN
Synonyms:
(R)-limonene 6-monooxygenase
(S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase
CYPIIC9
Cytochrome P450 2C9
P-450MP
P450 MP-4/MP-8
P450 PB-1
S-mephenytoin 4-hydroxylase
EC-Numbers:1.14.13.48
1.14.13.49
1.14.13.80
Organism:Homo sapiens
Human
PDB IDs:1OG2 1OG5 1R9O
Structure:
1R9O

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----
----
----
----
19000---

References:

10991840
11302937
7924124
9293615
Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonamides on hepatic cytochrome P4502C activity in vitro, and correlation with some molecular descriptors in the dwarf goat (Caprus hircus aegagrus).. W M Zweers-Zeilmaker; G J Horbach; R F Witkamp (1997) Xenobiotica; the fate of foreign compounds in biological systems display abstract
1. The aim of the present study was to investigate the potency of various sulfonamides to inhibit tolbutamide hydroxylation (a CYP2C activity) in hepatic microsomal fractions and hepatocytes of the dwarf goat. Also a number of suggested substrates for human CYP2C9 was investigated. 2. From Dixon plots (microsomal fractions) it was observed that all compounds were competitive inhibitors of tolbutamide hydroxylation. Phenytoin (PT) showed the lowest Ki. Ki for the sulfonamides ranged between 205 and 4546 microM, sulfadoxine having the lowest Ki followed by sulfadimethoxine, sulfamoxole, sulfadimidine and sulfaphenazole. 3. In hepatocytes sulfaphenazole and diclofenac were the most potent inhibitors. 4. Out data indicate that PT, diclofenac (DF) and phenylbutazone (PBZ) are relative strong competitive inhibitors of tolbutamide hydroxylation and they are probably also substrates for the same enzyme. Differential inhibition of tolbutamide hydroxylation by sulfonamides was observed. 5. Correlation of structural parameters with the inhibition constant or the inhibition in hepatocytes showed that molecular volume, polarizability and molecular surface area are important parameters in determining the rate of inhibition of tolbutamide hydroxylation by sulfonamides in both microsomes and hepatocytes. In addition, log Poct are also involved in determining inhibition constants in microsomal fractions.
9663807