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Drug-Target Interaction

Drug

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PubChem ID:4771
Structure:
Synonyms:
(alpha,alpha)-Dimethylphenethylamine
1,1-Dimethyl-2-phenylethylamine
1-(2-Methylphenyl)-2-propylamin
1-(2-Tolyl)-2-propylamine
1197-21-3
1197-21-3 (hydrochloride)
122-09-8
12674-13-4
2-Amino-2-methyl-1-phenylpropane
2-methyl-1-phenyl-2-propanamine
2-methyl-1-phenylpropan-2-amine
2-Phenyl-tert-butylamine
2-Propylamine, 1-(2-methylphenyl)-
35373-71-8
4-12-00-02820 (Beilstein Handbook Reference)
5580-32-5
9008-94-0
AC1L1IX2
Adipex-P
AKOS004123261
alpha,alpha-Dimethyl-beta-phenylethylamine
alpha,alpha-Dimethylbenzeneethanamine
alpha,alpha-Dimethylphenethylamine
alpha,alpha-Dimethylphenylethylamine
alpha-Benzylisopropylamine
alpha.,.alpha.-dimethyl-Benzeneethanamine
AmbkkkkK744
Benzeneethanamine, .alpha.,.alpha.-dimethyl-
Benzeneethanamine, alpha,alpha-dimethyl-
BRN 0970319
C07438
C10H15N
CHEBI:8080
CHEMBL1574
D05458
DB00191
DEA No. 1640
Duromine
EINECS 204-522-1
Ethanamine, 1,1-dimethyl-2-phenyl-
Fastin
Fentermina
Fentermina [INN-Spanish]
HMS2093B16
HSDB 3158
Inoamin
Ionamin
Ionamine
Linyl
Lipopill
Lonamin
LS-103327
Mirapront
Normephentermine
Obenix
Obermine
Oby-Trim
Omnibex
Ona Mast
Ortetamin
Ortetamina
Ortetamine
Ortetamine [INN]
Ortetaminum
Phenethylamine, .alpha.,.alpha.-dimethyl-
Phenethylamine, alpha,alpha-dimethyl-
Phentercot
Phentermine
Phentermine (USAN/INN)
Phentermine Hcl
Phentermine Hydrochloride
Phentermine Resin 30
Phentermine resin complex
Phentermine [USAN:BAN:INN]
Phentermine [USAN:INN:BAN]
Phenterminum
Phenterminum [INN-Latin]
Phentride
Phentrol
Phentrol 2
Phentrol 3
Phentrol 4
Phenyl-tert-butylamine
Phenyl-tertiary-butylamine
Pro-Fast
RCRA waste no. P046
RCRA waste number P046
UNII-C045TQL4WP
UNII-VF4N11KKKR
Wilpo
Zantryl
ATC-Codes:
Side-Effects:
Side-EffectFrequency
constipation0
dysphoria0
agitation0
urticaria0
tremor0
tachycardia0
palpitations0
impotence0
pulmonary hypertension0
headache0
euphoria0
dizziness0
diarrhea0
insomnia0

Target

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Uniprot ID:CP1A2_HUMAN
Synonyms:
CYPIA2
Cytochrome P450 1A2
P(3)450
P450 4
P450-P3
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:2HI4
Structure:
2HI4

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

9690701
Appetite suppressant drugs as inhibitors of human cytochromes P450: in vitro inhibition of P450-2D6 by D- and L-fenfluramine, but not phentermine.. L L von Moltke; D J Greenblatt; D A Ciraulo; J M Grassi; B W Granda; S X Duan; J S Harmatz; R I Shader (1998) Journal of clinical psychopharmacology display abstract
The activity of D-fenfluramine, L-fenfluramine, and phentermine as inhibitors of five human cytochromes P450 was evaluated using human liver microsomes in vitro. All three compounds produced negligible inhibition of P450-1A2, -2C9, -2E1, and -3A. Phentermine also did not inhibit P450-2D6. However, D- and L-fenfluramine significantly inhibited P450-2D6 activity as measured by dextromethorphan O-demethylation, with mean 50% inhibitory concentrations (15.1 microM) within one order of magnitude of that for fluoxetine (2.7 microM). Findings from the in vitro assay are consistent with clinical studies showing significant inhibition of desipramine clearance by coadministration of fenfluramine.