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Drug-Target Interaction

Drug

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PubChem ID:4688
Structure:
Synonyms:
-amine
2-12-00-00548 (Beilstein Handbook Reference)
2-Propynylamine, N-benzyl-N-methyl-
306-07-0 (HYDROCHLORIDE)
555-57-7
A 19120
AB00053516
AC1L1IQA
AC1Q3X8K
AC1Q3X8L
AI3-62058
AIDS-155936
AIDS155936
Benzenemethanamine,
Benzenemethanamine, N-methyl-N-2-propynyl-
Benzyl-methyl-2-propinylamin
Benzyl-methyl-2-propinylamin [Czech]
BENZYLAMINE, N-METHYL-N-2-PROPYNYL-
Benzylmethylpropargylamine
Benzylmethylpropynylamine
BPBio1_000117
BRD-K83597974-003-05-7
BRN 1938132
BSPBio_000105
BSPBio_002159
C07414
C11H13N
CAS-306-07-0
CBChromo1_000308
CCG-205102
CCRIS 6740
CHEBI:128477
CHEMBL673
D08453
DB01626
DivK1c_000053
DPWPWRLQFGFJFI-UHFFFAOYSA-
EINECS 209-101-6
Eudatin
Eutonyl
Eutonyl-ten
Eutron
IDI1_000053
KBio1_000053
KBio2_001121
KBio2_003689
KBio2_006257
KBio3_001659
KBioGR_000918
KBioSS_001121
Lopac-P-8013
Lopac0_001022
LS-43403
M74253_ALDRICH
methylbenzylprop-2-ynylamine
Methylbenzylpropynylamine
Methylbenzylpropynylamine hydrochloride
MO 911
MO-911
N-Benzyl-N-methyl-2-propyn-1-amine
N-Benzyl-N-methyl-2-propynylamine
N-Benzyl-N-methyl-2-propynylamine hydrochloride
N-benzyl-N-methylprop-2-yn-1-amine
N-Methyl-N-(2-propynyl)benzylamine-
N-methyl-N-(phenylmethyl)prop-2-yn-1-amine
N-Methyl-N-2-propynylbenzylamine
N-Methyl-N-benzylpropynylamine
N-Methyl-N-propargylbenzylamine
NCGC00015841-01
NCGC00015841-02
NCGC00015841-03
NCGC00015841-04
NCGC00015841-05
NCGC00015841-06
NCGC00015841-07
NCGC00024240-03
nchembio.307-comp18
NINDS_000053
NSC43798
NSC43798 (HYDROCHLORIDE)
Paragyline
Pargilina
Pargilina [INN-Spanish]
Pargylamine
Pargylin
Pargyline
Pargyline (INN)
Pargyline chloride
Pargyline Hydrochloride
Pargyline [INN:BAN]
Pargylinum
Pargylinum [INN-Latin]
Prestwick0_000183
Prestwick1_000183
Prestwick2_000183
Prestwick3_000183
SPBio_001257
SPBio_002026
Spectrum2_001039
Spectrum3_000540
Spectrum4_000469
Spectrum5_001030
Spectrum_000641
ST079278
Supirdyl
UNII-9MV14S8G3E
Usaf a-19120
ATC-Codes:

Target

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Uniprot ID:Q7M053_RAT
Synonyms:
Aldehyde dehydrogenase
EC-Numbers:1.-.-.-
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

3342079
Acute effects of the aldehyde dehydrogenase inhibitors, disulfiram, pargyline and cyanamide, on circulating ketone body levels in the rat.. E G DeMaster; J M Stevens (1988) Biochemical pharmacology display abstract
Acetonemia is generally associated with the ketogenic states of fasting and diabetes. Disulfiram (DS), an inhibitor of aldehyde dehydrogenase (AlDH) that is used as an alcohol deterrent drug, is also known to elevate blood acetone in humans, but in the absence of a commensurate increase in its metabolic precursor, acetoacetate. We reexamined the effects of DS and other AlDH inhibitors on circulating ketone body levels in male rats of Sprague-Dawley descent and again demonstrated a 6- and 16-fold increase in blood acetone along with normal levels of acetoacetate at 6 and 24 hr after DS. Pargyline, another inhibitor of AlDH, maintained normal blood acetone levels in the presence of reduced acetoacetate levels. A third inhibitor of AlDH, cyanamide, administered to fasted and nonfasted rats, elevated blood acetone levels 10-fold over controls, with, however, a commensurate 5- and 7-fold increase in blood acetoacetate levels. The threshold values for the cyanamide-induced elevation of blood acetone and acetoacetate were equivalent, i.e. approximately 0.25 mmol/kg body weight (i.p.). The elevation of acetoacetate and the inhibition of hepatic catalase activity by cyanamide are not mechanistically linked, since 3-amino-1,2,4-triazole, another inhibitor of catalase, elevated blood acetone but not acetoacetate levels. These findings suggest that DS-induced acetonemia is due to inhibition of acetone metabolism, whereas enhanced acetone formation through acetoacetate contributes significantly to cyanamide-induced acetonemia.