Drug-Target Interaction

Drug

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PubChem ID:

4680

Structure:

Synonyms:

1-((3,4-Dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline

1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-isoquinoline

1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline

1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline

1-[(3,4-Dimethoxyphenyl)methyl]6,7-dimethoxyisoquinoline

1-[(3,4-Dimethoxyphenyl)methyl]6,7-dimethoxyisoquinoline;

1-{[3,4-bis(methyloxy)phenyl]methyl}-6,7-bis(methyloxy)isoquinoline

4-[(6,7-Dimethoxyisoquinolyl)methyl]-1,2-dimethoxybenzene

5-21-06-00182 (Beilstein Handbook Reference)

58-74-2

58-74-2 (FREE BASE )

6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline

6,7-Dimethoxy-1-veratrylisoquinoline

61-25-6

61-25-6 (HCL)

61-25-6 (hydrochloride)

AB00053515

AC1L1IPM

AC1Q4CFN

ACon1_000238

ACon1_002094

AIDS-000185

AIDS000185

AKOS000277460

Alapav

BAS 00674058

BPBio1_000470

BRD-K15567136-001-01-1

BRD-K15567136-003-06-6

BRN 0312930

BSPBio_000426

BSPBio_002153

C06533

C20H21NO4

Cardiospan

Cardoverina

CAS-61-25-6

CCG-202821

Ceraspan

Cerebid

Cerespan

CHEMBL19224

Chlorhydrate de Papaverine

D07425

DB01113

DB07725

Delapav

Dilaves

Dispamil

DivK1c_000321

Drapavel

Durapav

Dynovas

EINECS 200-397-2

EV1

Forpavin

Genabid

HSDB 3147

IDI1_000321

Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-

Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-

Isoquinoline, 6,7-dimethoxy-1-veratryl-

Isoquinoline, 6,7-dimethoxy-1-veratryl- (8CI)

Isoquinoline, 6,7-dimethoxy-1-veratryl-(8Cl)

KBio1_000321

KBio2_000471

KBio2_003039

KBio2_005607

KBio3_001653

KBioGR_000914

KBioSS_000471

Lopac-P-3510

Lopac0_000957

LS-85584

MEGxp0_001880

Mesotina (TN)

Myobid

NCGC00015810-01

NCGC00015810-02

NCGC00015810-03

NCGC00015810-04

NCGC00015810-05

NCGC00015810-06

NCGC00015810-07

NCGC00015810-08

NCGC00015810-09

NCGC00024428-03

NCGC00024428-04

nchembio.317-comp11

NCI60_003183

NINDS_000321

NSC 136630

NSC136630

NSC35443

NSC35443 (HCL)

Oprea1_387689

Oprea1_810508

Pameion

Pamelon

Panergon

PAP H

Papacon

Papalease

Papanerin

Papanerin-hcl

Papanerine

Papavarine Chlorhydrate

Papaverin

Papaverina

Papaverina [Italian]

Papaverine

Papaverine (BAN)

Papaverine Chlorohydrate

Papaverine Hcl

Papaverine Hydrochloride

Papaverine Monohydrochloride

Papaverine [BAN]

Papaverinium Chloride

Papaversan

Papital T.R.

Paptial T.R.

Pavabid

Pavabid Hp

Pavacap

Pavacels

Pavacen

Pavacot

Pavagen

Pavarine

Pavatest

Pavatine

Pavatym

Paverolan

Paveron

Pavnell

Prestwick0_000583

Prestwick1_000583

Prestwick2_000583

Prestwick3_000583

Qua bid

Ro-Papav

Robaxapap

RS 47

S-M-R

SDCCGMLS-0003037.P003

SPBio_001015

SPBio_002645

Spectrum2_000978

Spectrum3_000537

Spectrum4_000467

Spectrum5_001188

Spectrum_000071

ST023301

STK039035

STOCK1N-09376

TNP00305

UNII-DAA13NKG2Q

Vasal

Vaso-Pav

WLN: T66 CNJ B1R CO1 DO1& HO1 IO1

ZINC00056555

ATC-Codes:

Target

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Uniprot ID:

Q0VQP0_ALCBS

Synonyms:

Phosphoric diester hydrolase

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EC-Numbers:

3.1.4.-

Organism:

Alcanivorax borkumensis
strain SK2 / ATCC 700651 / DSM 11573

PDB IDs:

Binding Affinities:

Ki:	Kd:	Ic 50:	Ec50/Ic50:
-	-	-	-
-	-	-	-

References:

167381
Differences and similarities between guanosine 3',5'-cyclic monophosphate phosphodiesterase and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in neuroblastoma cells in culture.. K N Prasad; G Becker; K Tripathy (1975) Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) display abstract

There are phosphodiesterase activities in both particulate and supernatant fractions which hydrolyze guanosine 3',5'-cyclic monophosphate (cGMP) and adenosine 3',5'-cyclic monophosphate (cAMP) with an apparent Km of 2-8 muM and with an apparent Km of 44-222 muM. 4-(3-Butoxy-4-methoxybenzyl-2-imidazolidinone (RO20-1724) did not inhibit cGMP phosphodiesterase activity in homogenates of mouse neuroblastoma cells, but markedly inhibited cAMP phosphodiesterase activity. Papaverine and theophylline inhibited both cGMP and cAMP phosphodiesterase activities to about the same extent. The former was more potent than the latter. The specific activity of cGMP phosphodiesterase as a function of protein concentrations first increased and then decreased. The specific activity of cAMP phosphodiesterase decreased under a similar experimental condition.

193725
Comparative effect of chlorpromazine, imipramine and papaverine on the blood platelet function. V Bartel'; E Gluza; F Markvardt (1976) Farmakologiia i toksikologiia display abstract

With a view of decoding the mechanisms of their action the effect of papaverine, chlorpromazine and imipramine produced on a number of blood platelets hemostatic functions was studied. All the three drugs suppress in a characteristic fashion the aggregation on blood platelets caused by thrombin in the Tyrode solution and in a plasma defibrilated by heating, as well as by collogen and ADP in the citrated plasma. Unlike chlorpromazine and imipramine papaverine exerts a strong inhibiting action on the phosphodiesterase activity. Chlorpromazine and imipramine suppress the absorption of serotonin and retraction more intensively than this is done by papaverine and call forth morphological changes in the blood platelets that proceed parallel with changes in the intensity of the photodiffusion and liberation of endogenous serotonin. It is postulated that chlorpromazine and imipramine manifest their inhibitory effect through nonspecific damage of the blood platelets membranes, whereas papaverine does this through exchange of adenine-nucleotides and, especially, of 3',5'-AMP.