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Drug-Target Interaction

Drug

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PubChem ID:4680
Structure:
Synonyms:
1-((3,4-Dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline
1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-isoquinoline
1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline
1-[(3,4-Dimethoxyphenyl)methyl]6,7-dimethoxyisoquinoline
1-[(3,4-Dimethoxyphenyl)methyl]6,7-dimethoxyisoquinoline;
1-{[3,4-bis(methyloxy)phenyl]methyl}-6,7-bis(methyloxy)isoquinoline
4-[(6,7-Dimethoxyisoquinolyl)methyl]-1,2-dimethoxybenzene
5-21-06-00182 (Beilstein Handbook Reference)
58-74-2
58-74-2 (FREE BASE )
6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline
6,7-Dimethoxy-1-veratrylisoquinoline
61-25-6
61-25-6 (HCL)
61-25-6 (hydrochloride)
AB00053515
AC1L1IPM
AC1Q4CFN
ACon1_000238
ACon1_002094
AIDS-000185
AIDS000185
AKOS000277460
Alapav
BAS 00674058
BPBio1_000470
BRD-K15567136-001-01-1
BRD-K15567136-003-06-6
BRN 0312930
BSPBio_000426
BSPBio_002153
C06533
C20H21NO4
Cardiospan
Cardoverina
CAS-61-25-6
CCG-202821
Ceraspan
Cerebid
Cerespan
CHEMBL19224
Chlorhydrate de Papaverine
D07425
DB01113
DB07725
Delapav
Dilaves
Dispamil
DivK1c_000321
Drapavel
Durapav
Dynovas
EINECS 200-397-2
EV1
Forpavin
Genabid
HSDB 3147
IDI1_000321
Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-
Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-
Isoquinoline, 6,7-dimethoxy-1-veratryl-
Isoquinoline, 6,7-dimethoxy-1-veratryl- (8CI)
Isoquinoline, 6,7-dimethoxy-1-veratryl-(8Cl)
KBio1_000321
KBio2_000471
KBio2_003039
KBio2_005607
KBio3_001653
KBioGR_000914
KBioSS_000471
Lopac-P-3510
Lopac0_000957
LS-85584
MEGxp0_001880
Mesotina (TN)
Myobid
NCGC00015810-01
NCGC00015810-02
NCGC00015810-03
NCGC00015810-04
NCGC00015810-05
NCGC00015810-06
NCGC00015810-07
NCGC00015810-08
NCGC00015810-09
NCGC00024428-03
NCGC00024428-04
nchembio.317-comp11
NCI60_003183
NINDS_000321
NSC 136630
NSC136630
NSC35443
NSC35443 (HCL)
Oprea1_387689
Oprea1_810508
Pameion
Pamelon
Panergon
PAP H
Papacon
Papalease
Papanerin
Papanerin-hcl
Papanerine
Papavarine Chlorhydrate
Papaverin
Papaverina
Papaverina [Italian]
Papaverine
Papaverine (BAN)
Papaverine Chlorohydrate
Papaverine Hcl
Papaverine Hydrochloride
Papaverine Monohydrochloride
Papaverine [BAN]
Papaverinium Chloride
Papaversan
Papital T.R.
Paptial T.R.
Pavabid
Pavabid Hp
Pavacap
Pavacels
Pavacen
Pavacot
Pavagen
Pavarine
Pavatest
Pavatine
Pavatym
Paverolan
Paveron
Pavnell
Prestwick0_000583
Prestwick1_000583
Prestwick2_000583
Prestwick3_000583
Qua bid
Ro-Papav
Robaxapap
RS 47
S-M-R
SDCCGMLS-0003037.P003
SPBio_001015
SPBio_002645
Spectrum2_000978
Spectrum3_000537
Spectrum4_000467
Spectrum5_001188
Spectrum_000071
ST023301
STK039035
STOCK1N-09376
TNP00305
UNII-DAA13NKG2Q
Vasal
Vaso-Pav
WLN: T66 CNJ B1R CO1 DO1& HO1 IO1
ZINC00056555
ATC-Codes:

Target

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Uniprot ID:Q0VQP0_ALCBS
Synonyms:
Phosphoric diester hydrolase
EC-Numbers:3.1.4.-
Organism:Alcanivorax borkumensis
strain SK2 / ATCC 700651 / DSM 11573
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----

References:

167381
Differences and similarities between guanosine 3',5'-cyclic monophosphate phosphodiesterase and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in neuroblastoma cells in culture.. K N Prasad; G Becker; K Tripathy (1975) Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) display abstract
There are phosphodiesterase activities in both particulate and supernatant fractions which hydrolyze guanosine 3',5'-cyclic monophosphate (cGMP) and adenosine 3',5'-cyclic monophosphate (cAMP) with an apparent Km of 2-8 muM and with an apparent Km of 44-222 muM. 4-(3-Butoxy-4-methoxybenzyl-2-imidazolidinone (RO20-1724) did not inhibit cGMP phosphodiesterase activity in homogenates of mouse neuroblastoma cells, but markedly inhibited cAMP phosphodiesterase activity. Papaverine and theophylline inhibited both cGMP and cAMP phosphodiesterase activities to about the same extent. The former was more potent than the latter. The specific activity of cGMP phosphodiesterase as a function of protein concentrations first increased and then decreased. The specific activity of cAMP phosphodiesterase decreased under a similar experimental condition.
193725
Comparative effect of chlorpromazine, imipramine and papaverine on the blood platelet function. V Bartel'; E Gluza; F Markvardt (1976) Farmakologiia i toksikologiia display abstract
With a view of decoding the mechanisms of their action the effect of papaverine, chlorpromazine and imipramine produced on a number of blood platelets hemostatic functions was studied. All the three drugs suppress in a characteristic fashion the aggregation on blood platelets caused by thrombin in the Tyrode solution and in a plasma defibrilated by heating, as well as by collogen and ADP in the citrated plasma. Unlike chlorpromazine and imipramine papaverine exerts a strong inhibiting action on the phosphodiesterase activity. Chlorpromazine and imipramine suppress the absorption of serotonin and retraction more intensively than this is done by papaverine and call forth morphological changes in the blood platelets that proceed parallel with changes in the intensity of the photodiffusion and liberation of endogenous serotonin. It is postulated that chlorpromazine and imipramine manifest their inhibitory effect through nonspecific damage of the blood platelets membranes, whereas papaverine does this through exchange of adenine-nucleotides and, especially, of 3',5'-AMP.