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Drug-Target Interaction

Drug

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PubChem ID:4680
Structure:
Synonyms:
1-((3,4-Dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline
1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-isoquinoline
1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline
1-[(3,4-Dimethoxyphenyl)methyl]6,7-dimethoxyisoquinoline
1-[(3,4-Dimethoxyphenyl)methyl]6,7-dimethoxyisoquinoline;
1-{[3,4-bis(methyloxy)phenyl]methyl}-6,7-bis(methyloxy)isoquinoline
4-[(6,7-Dimethoxyisoquinolyl)methyl]-1,2-dimethoxybenzene
5-21-06-00182 (Beilstein Handbook Reference)
58-74-2
58-74-2 (FREE BASE )
6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline
6,7-Dimethoxy-1-veratrylisoquinoline
61-25-6
61-25-6 (HCL)
61-25-6 (hydrochloride)
AB00053515
AC1L1IPM
AC1Q4CFN
ACon1_000238
ACon1_002094
AIDS-000185
AIDS000185
AKOS000277460
Alapav
BAS 00674058
BPBio1_000470
BRD-K15567136-001-01-1
BRD-K15567136-003-06-6
BRN 0312930
BSPBio_000426
BSPBio_002153
C06533
C20H21NO4
Cardiospan
Cardoverina
CAS-61-25-6
CCG-202821
Ceraspan
Cerebid
Cerespan
CHEMBL19224
Chlorhydrate de Papaverine
D07425
DB01113
DB07725
Delapav
Dilaves
Dispamil
DivK1c_000321
Drapavel
Durapav
Dynovas
EINECS 200-397-2
EV1
Forpavin
Genabid
HSDB 3147
IDI1_000321
Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-
Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-
Isoquinoline, 6,7-dimethoxy-1-veratryl-
Isoquinoline, 6,7-dimethoxy-1-veratryl- (8CI)
Isoquinoline, 6,7-dimethoxy-1-veratryl-(8Cl)
KBio1_000321
KBio2_000471
KBio2_003039
KBio2_005607
KBio3_001653
KBioGR_000914
KBioSS_000471
Lopac-P-3510
Lopac0_000957
LS-85584
MEGxp0_001880
Mesotina (TN)
Myobid
NCGC00015810-01
NCGC00015810-02
NCGC00015810-03
NCGC00015810-04
NCGC00015810-05
NCGC00015810-06
NCGC00015810-07
NCGC00015810-08
NCGC00015810-09
NCGC00024428-03
NCGC00024428-04
nchembio.317-comp11
NCI60_003183
NINDS_000321
NSC 136630
NSC136630
NSC35443
NSC35443 (HCL)
Oprea1_387689
Oprea1_810508
Pameion
Pamelon
Panergon
PAP H
Papacon
Papalease
Papanerin
Papanerin-hcl
Papanerine
Papavarine Chlorhydrate
Papaverin
Papaverina
Papaverina [Italian]
Papaverine
Papaverine (BAN)
Papaverine Chlorohydrate
Papaverine Hcl
Papaverine Hydrochloride
Papaverine Monohydrochloride
Papaverine [BAN]
Papaverinium Chloride
Papaversan
Papital T.R.
Paptial T.R.
Pavabid
Pavabid Hp
Pavacap
Pavacels
Pavacen
Pavacot
Pavagen
Pavarine
Pavatest
Pavatine
Pavatym
Paverolan
Paveron
Pavnell
Prestwick0_000583
Prestwick1_000583
Prestwick2_000583
Prestwick3_000583
Qua bid
Ro-Papav
Robaxapap
RS 47
S-M-R
SDCCGMLS-0003037.P003
SPBio_001015
SPBio_002645
Spectrum2_000978
Spectrum3_000537
Spectrum4_000467
Spectrum5_001188
Spectrum_000071
ST023301
STK039035
STOCK1N-09376
TNP00305
UNII-DAA13NKG2Q
Vasal
Vaso-Pav
WLN: T66 CNJ B1R CO1 DO1& HO1 IO1
ZINC00056555
ATC-Codes:

Target

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Uniprot ID:PA21B_CANFA
Synonyms:
Group IB phospholipase A2
Phosphatidylcholine 2-acylhydrolase
Phospholipase A2
EC-Numbers:3.1.1.4
Organism:Canis familiaris
Dog
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

41058
Anti-inflammatory and platelet anti-aggregant activity of phospholipase-A2 inhibitors.. E Vallee; J Gougat; J Navarro; J F Delahayes (1979) The Journal of pharmacy and pharmacology display abstract
Mepacrine, papaverine, p-bromophenacyl bromide and 2,3-dibromo(4'-cyclohexyl-3'-chloro)-phenyl-4-oxo-butyric acid (CB 874) inhibit the hydrolysis of phospholipids induced by thrombin in dog platelets. They also exhibit anti-inflammatory and anti-aggregant properties. These biological activities may be explained by a direct or indirect inhibitory action on phospholipase A2. Phospholipase A2 inhibitors may block not only the release of arachidonic acid and its subsequent conversion into prostaglandins but also the formation of lysophospholipids involved in inflammation and/or platelet aggregation.