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Drug-Target Interaction

Drug

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PubChem ID:4614
Structure:
Synonyms:
.Beta.-(4,5-Diphenyloxazol-2-yl)propionic acid
2-Oxazolepropanoic acid, 4,5-diphenyl-
2-OXAZOLEPROPIONIC ACID, 4,5-DIPHENYL-
21256-18-8
3-(4, 5-Diphenyl-2-oxazolyl)propenoic acid
3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid
3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid;
3-(4,5-Diphenyl-2-oxazolyl)propenoic acid
3-[4,5-di(phenyl)-1,3-oxazol-2-yl]propanoic acid
4, 5-Diphenyl-2-oxazolepropionic acid
4,5-Diphenyl-2-oxazolepropanoic acid
4,5-Diphenyl-2-oxazolepropionic acid
AB00514024
AC-11349
AC1L1IK7
AC1Q759J
AC1Q759K
Actirin
AIDS-128972
AIDS128972
AKOS000206807
Alvo
beta-(4,5-Diphenyloxazol-2-yl)propionic acid
BIDD:GT0438
BIDD:PXR0149
BPBio1_001122
BRD-K25394294-001-05-7
BRN 1083168
BSPBio_001020
BSPBio_002696
C07356
C18H15NO3
CAS-21256-18-8
CCG-36508
CHEBI:239225
CHEMBL1071
CPD000058286
D00463
Daypro
Daypro (TN)
DB00991
Deflam
Duraprox
EINECS 244-296-1
EU-0100944
HMS1571C22
HMS1922P17
HMS2051L15
HMS2093O08
HMS2098C22
HMS3262N10
HMS566H22
HSDB 7586
I14-8703
KBio3_001916
KBioGR_001722
Lopac-O-9637
Lopac0_000944
LS-100216
lyl)propenoic acid
Maybridge1_008800
MLS000759535
MLS001424072
NCGC00014711
NCGC00014711-02
NCGC00014711-03
NCGC00014711-04
NCGC00014711-05
NCGC00014711-06
NCGC00014711-07
NCGC00014711-08
NCGC00014711-09
NCGC00014711-10
NCGC00014711-11
NCGC00094249-01
NCGC00094249-02
NCGC00094249-03
NCGC00094249-04
NCGC00094249-05
NCGC00094249-06
NCGC00094249-07
NCI310839
NCI60_002681
NCIStruc1_000799
NCIStruc2_000787
NSC 310839
NSC-310839
NSC310839
O 9637
O9637_SIGMA
Oprea1_509470
Oxaprozin
Oxaprozin (JP15/USAN/INN)
Oxaprozin (JP16/USAN/INN)
Oxaprozin [USAN:BAN:INN:JAN]
Oxaprozina
Oxaprozina [INN-Spanish]
Oxaprozine
Oxaprozine [INN-French]
Oxaprozinum
Oxaprozinum [INN-Latin]
Prestwick0_001060
Prestwick1_001060
Prestwick2_001060
Prestwick3_001060
SAM001246770
SBB053166
SMR000058286
SPBio_001652
SPBio_002940
SPECTRUM1505267
Spectrum2_001696
Spectrum3_001078
Spectrum4_001231
SR-01000076053-3
SS 00042
UNII-MHJ80W9LRB
Voir
WY 21743
WY-21,743
WY-21743
Xopane
ATC-Codes:
Side-Effects:
Side-EffectFrequency
thrombocytopenia0.0010
interstitial nephritis0.0010
nephrotic syndrome0.0010
palpitations0.0010
pancreatitis0.0010
pancytopenia0.0010
serum sickness0.0010
sinusitis0.0010
stevens - johnson syndrome0.0010
menstrual flow0.0010
leucopenia0.0010
acute renal failure0.0010
agranulocytosis0.0010
alopecia0.0010
anemia0.0010
exfoliative dermatitis0.0010
ecchymoses0.0010
lyell0.0010
erythema multiforme0.0010
hepatitis0.0010
infections0.0010
stomatitis0
nervousness0
ulcer0
tachycardia0
dyspepsia0
convulsions0
asthma0
anorexia0
congestive heart failure0
hematuria0
paresthesia0
malaise0
vasculitis0
weight loss0
weight gain0
rash0
eructation0
constipation0
weakness0
polyuria0
aplastic anemia0
somnolence0
hypotension0
heartburn0
elevated liver enzymes0
upper respiratory tract infection0
hallucinations0
increased sweating0
eosinophilia0
melena0
vomiting0
hearing loss0
angioedema0
coma0
proteinuria0
hemorrhage0
abdominal pain0
dyspnea0
insomnia0
sepsis0
headache0
cystitis0
gastritis0
hemolytic anemia0
urticaria0
dry mouth0
jaundice0
renal insufficiency0
arrhythmia0
hepatic failure0
nausea0
pruritus0
hypertension0
lymphadenopathy0
rectal hemorrhage0
fever0
myocardial infarction0
drug hypersensitivity0
hematemesis0
esophagitis0
confusion0
syncope0
photosensitivity0
meningitis0
diarrhea0
tinnitus0
dysuria0
gastrointestinal hemorrhage0
anaphylaxis0
anxiety0
tremor0
peptic ulcer0
vertigo0
asthenia0
conjunctivitis0
pneumonia0
blurred vision0
purpura0
flatulence0
hyperglycemia0
edema0
dizziness0
glossitis0

Target

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Uniprot ID:CP2C9_HUMAN
Synonyms:
(R)-limonene 6-monooxygenase
(S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase
CYPIIC9
Cytochrome P450 2C9
P-450MP
P450 MP-4/MP-8
P450 PB-1
S-mephenytoin 4-hydroxylase
EC-Numbers:1.14.13.48
1.14.13.49
1.14.13.80
Organism:Homo sapiens
Human
PDB IDs:1OG2 1OG5 1R9O
Structure:
1R9O

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: