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Drug-Target Interaction

Drug

show drug details
PubChem ID:4583
Structure:
Synonyms:
( -)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazin-6-carbonsaeure
(+-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
(+/-)-9-fluoro-2, 3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1, 2, 3-de]-1, 4-benzoxazine-6-carboxylic acid
(+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperaz inyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
(+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7- -oxo-7H-pyrido(1,2,3-de)- -1,4-benzoxazine-6-carboxylic acid
(+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
(+/-)-Floxin
118120-51-7
33703_FLUKA
33703_RIEDEL
7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (+-)-
7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (+-)-
82419-36-1
83380-47-6
85344-55-4
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]ox
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
AB00513820
AIDS-001339
AIDS001339
BPBio1_000345
BRN 3657947
BSPBio_000313
BSPBio_003117
C07321
C18H20FN3O4
CCRIS 5233
CHEBI:7731
D00453
DB01165
DB03034
DEXTROFLOXACINE
DivK1c_000721
DL 8280
DL-8280
DR-3355
EU-0100904
Exocin
Exocine
Floxin
Floxin (TN)
FLOXIN IN DEXTROSE 5%
FLOXIN IN DEXTROSE 5% IN PLASTIC CONTAINER
Floxin otic
HOE 280
Hoe-280
IDI1_000721
KBio1_000721
KBio2_001666
KBio2_004234
KBio2_006802
KBio3_002617
KBioGR_000667
KBioSS_001666
Lopac0_000904
LS-133259
MLS000028749
MLS001074203
NCGC00094219-01
NCGC00094219-02
NCGC00094219-03
NCGC00094219-04
NCGC00094219-05
NCGC00094219-06
NCGC00178284-01
NCGC00178284-02
NINDS_000721
NSC727071
O8757_SIGMA
Ocuflox
Oflocet
Ofloxacin
Ofloxacin (JP15/USP/INN)
Ofloxacin Otic
Ofloxacin [USAN:BAN:INN:JAN]
ofloxacin, (+)-
OFLOXACIN, (+-)-
Ofloxacin, (S)-Isomer
Ofloxacina
Ofloxacina [DCIT]
Ofloxacine
Ofloxacine [French]
Ofloxacino
Ofloxacino [Spanish]
Ofloxacinum
Ofloxacinum [Latin]
OFLX
OFX
Oprea1_242882
ORF 18489
ORF-28489
Oxaldin
Prestwick0_000237
Prestwick1_000237
Prestwick2_000237
Prestwick3_000237
PT 01
Ru-43280
SMR000058192
SPBio_001387
SPBio_002234
SPECTRUM1502044
Spectrum2_001464
Spectrum3_001499
Spectrum4_000324
Spectrum5_001063
Spectrum_001186
ST073364
STK256723
Tarivid
Visiren
WP-0405
XED
Zanocin
ATC-Codes:
Side-Effects:
Side-EffectFrequency
pruritus0.020666666
paraesthesia0.01
earache0.0080
dizziness0.0053333333
vertigo0.0050
rash0.004857142
headache0.0016666667
vasculitis0.0010
tinnitus0.0010
vascular disorders0.0010
mediastinal disorders0.0010
cardiac disorders0.0010
hepatitis0.0010
pyrosis0.0010
dysphonia0.0010
hemorrhage0.0010
glomerulonephritis0.0010
gi hemorrhage0.0010
ecchymosis0.0010
cataracts0.0010
edema0.0010
eosinophilia0.0010
erythema multiforme0.0010
agitation0.0010
hepatic failure0.0010
encephalopathy0.0010
pyrexia0.0010
cerebral thrombosis0.0010
myasthenia gravis0.0010
vision disturbance0.0010
hiccough0.0010
thrombocytopenia0.0010
rhabdomyolysis0.0010
thrombotic thrombocytopenic purpura0.0010
pulmonary edema0.0010
psychosis0.0010
myositis0.0010
interstitial nephritis0.0010
nephrosis0.0010
nightmares0.0010
petechiae0.0010
peripheral neuropathy0.0010
pancytopenia0.0010
weakness0.0010
leukopenia0.0010
scotoma0.0010
serum sickness0.0010
tendinitis0.0010
tachycardia0.0010
hypersensitivity0.0010
hypoglycemia0.0010
syncope0.0010
hypotension0.0010
suicide attempt0.0010
stridor0.0010
jaundice0.0010
stevens - johnson syndrome0.0010
shock0.0010
acute renal failure0.0010
intestinal perforation0.0010
lightheadedness0.0010
anaphylactic shock0.0010
bronchospasm0.0010
anemia0.0010
interstitial pneumonia0.0010
aplastic anemia0.0010
hemolytic anemia0.0010
hypoacusis0.0010
apnea0.0010
myalgia0.0010
angioneurotic edema0.0010
vaginal candidiasis0.0010
toxic epidermal necrolysis0.0010
pseudomembranous colitis0.0010
anosmia0.0010
vision blurred0.0010
colitis0.0010
photosensitivity0.0010
dysphasia0.0010
phobia0.0010
paranoia0.0010
ataxia0.0010
agranulocytosis0.0010
hepatic necrosis0.0010
amnesia0.0010
abnormal eeg0.0010
leukocytoclastic vasculitis0.0010
allergic pneumonitis0.0010
dyspnea0.0010
diplopia0.0010
mental deficiency0
increased sweating0
seborrhea0
seizures0
stomatitis0
thrombocythemia0
sleep disorder0
upper respiratory tract infection0
skin ulcer0
allergic reaction0
rhinitis0
urinary incontinence0
pharyngitis0
phlebitis0
pleural effusion0
pleurisy0
pneumothorax0
polyuria0
bone pain0
proteinuria0
weight loss0
pulmonary embolism0
purpura0
pyuria0
ards0
rhinorrhea0
renal failure0
hypophosphatemia0
dry mouth0
respiratory arrest0
vomiting0
hyperpigmentation0
viral infection0
migraine0
vestibular disorders0
vaginal discharge0
dry skin0
urinary retention0
hypomagnesemia0
photophobia0
emotional lability0
muscle weakness0
stupor0
chills0
chest pain substernal0
eye pain0
ventricular tachycardia0
ventricular fibrillation0
malaise0
neuropathy0
supraventricular tachycardia0
lymphadenopathy0
paralysis0
synovitis0
manic0
abnormal gait0
sweating0
thrombophlebitis0
bradycardia0
hypoxia0
vaginitis0
insomnia0
urticaria0
sepsis0
erythema0
dysesthesia0
tremor0
urinary frequency0
flushing0
somnolence0
diarrhea0
diabetes mellitus0
exfoliative dermatitis0
dermatitis0
delirium0
dehydration0
dysphagia0
cough0
convulsions0
constipation0
dysmenorrhea0
dyspepsia0
dysuria0
vitreous floaters0
flatulence0
fatigue0
ocular infection0
euphoria0
esophagitis0
erythema nodosum0
epistaxis0
abdominal pain0
endocarditis0
eczema0
connective tissue disorders0
confusion0
asthma0
asthenia0
ascites0
arthritis0
arthralgia0
arrhythmia0
anxiety0
anorexia0
angina pectoris0
alopecia0
albuminuria0
atelectasis0
atrial fibrillation0
back pain0
infectious diseases0
coma0
cholelithiasis0
cholecystitis0
chest pain0
cerebrovascular disorder0
carcinoma0
moniliasis0
bronchitis0
breast disorders0
clotting0
acidosis0
gangrene0
pancreatitis0
melena0
hemorrhoids0
lymphopenia0
lymphocytosis0
copd0
leukocytosis0
leg pain0
leg cramps0
laryngitis0
kidney calculus0
keratitis0
menorrhagia0
metrorrhagia0
muscle cramps0
palpitations0
pain in limb0
pain0
osteomyelitis0
nystagmus0
neutropenia0
nervousness0
tumor0
nausea0
myocardial infarction0
fungal infection0
arthrosis0
influenza0
hematoma0
heart failure0
heart block0
cardiac arrest0
hallucinations0
halitosis0
gout0
glycosuria0
glossitis0
gastroesophageal reflux0
gastroenteritis0
hematuria0
hemoptysis0
herpes0
impotence0
postural hypotension0
hyponatremia0
hypokalemia0
hypertension0
hypernatremia0
hyperkalemia0
hyperglycemia0
hyperesthesia0
hot flashes0
herpes simplex0
gastritis0

Target

show target details
Uniprot ID:GYRB_STAAC
Synonyms:
DNA gyrase subunit B
EC-Numbers:5.99.1.3
Organism:Staphylococcus aureus
strain COL
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: