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Drug-Target Interaction

Drug

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PubChem ID:4542
Structure:
Synonyms:
13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetrade
17-ethynyl-17-hydroxy-18a-homoestr-4-en-3-one
18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17.alpha.)-(.+/-.)-
6533-00-2
CHEBI:7630
LD norgestrel
Methylnorethindrone
Norgestrel
Norgestrelum
Oprea1_224559
Side-Effects:
Side-EffectFrequency
hypertrichosis0.0010
oligomenorrhea0.0010
otitis media0.0010
ovarian cyst0.0010
pain0.0010
pelvic pain0.0010
pharyngitis0.0010
pneumonia0.0010
polyps0.0010
ectopic pregnancy0.0010
pruritis0.0010
rhinitis0.0010
nervousness0.0010
neoplasm0.0010
infections0.0010
influenza0.0010
leg pain0.0010
mastitis0.0010
breast pain0.0010
mediastinal disorders0.0010
chloasma0.0010
menstrual disorder0.0010
intermenstrual bleeding0.0010
musculoskeletal pain0.0010
nausea0.0010
sciatica0.0010
seborrhoea0.0010
sinusitis0.0010
fibroadenoma of breast0.0010
lactation nonpuerperal0.0010
iud complication0.0010
pelvic inflammatory disease0.0010
micturition frequency0.0010
breast cancer0.0010
sweating increased0.0010
acne0.0010
abdominal bloating0.0010
dyspareunia0.0010
breast neoplasm0.0010
dry skin0.0010
vaginal bleeding0.0010
tendonitis0.0010
tooth disorder0.0010
toothache0.0010
upper respiratory tract infection0.0010
urinary incontinence0.0010
urinary tract infection0.0010
urticaria0.0010
uterine fibroid0.0010
vertigo0.0010
weight increase0.0010
migraine0.0010
allergic reaction0.0010
hypertension0.0010
abdominal pain0.0010
cystitis0.0010
cysts0.0010
libido decreased0.0010
diarrhea0.0010
dizziness0.0010
cervicitis0.0010
dysmenorrhea0.0010
dysuria0.0010
edema0.0010
connective tissue disorders0.0010
vaginal discharge0.0010
alopecia0.0010
amenorrhea0.0010
angioedema0.0010
arrhythmia0.0010
asthma0.0010
back pain0.0010
breast disorders0.0010
bronchitis0.0010
candidiasis0.0010
endocrine disorders0.0010
endometriosis0.0010
eczema0.0010
headache0.0010
bleeding0.0010
haemorrhoids0.0010
cardiac disorders0.0010
fatigue0.0010
rash0.0010
hirsutism0.0010
fever0.0010
allergy0.0010
endometritis0.0010
anemia0
hypomenorrhea0
depressed mood0
hematuria0
hematoma0
acute appendicitis0
emotional lability0
polydipsia0
weight loss0
lightheadedness0
chest pain0
myalgia0
hypochromic anemia0
herpes simplex0
anorexia0
insomnia0
tearfulness0
menorrhagia0
breast tenderness0
leg cramps0
asthenia0
menometrorrhagia0
anxiety0
vulvovaginitis0
dermatitis0
contact dermatitis0
polymenorrhea0
purpura0
somnolence0
numbness0
dyspepsia0
dyspnea0
abdominal distention0
papilloma0
palpitations0
syncope0
fungal infection0
tonsillitis0
vomiting0
abnormal vision0
pms0
varicose vein0
vaginitis0
constipation0
corpus luteum cyst0
cough0
ulcer0
folliculitis0
flatulence0
otitis0

Target

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Uniprot ID:ESR1_HUMAN
Synonyms:
ER
ER-alpha
Estradiol receptor
Estrogen receptor
Nuclear receptor subfamily 3 group A member 1
EC-Numbers:-
Organism:Homo sapiens
Human
PDB IDs:1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1PCG 1QKT 1QKU 1R5K 1SJ0 1UOM 1X7E 1X7R 1XP1 1XP6 1XP9 1XPC 1XQC 1YIM 1YIN 1ZKY 2AYR 2B1V 2B1Z 2B23 2BJ4 2FAI 2G44 2G5O 2I0J 2IOG 2IOK 2JF9 2JFA 2OCF 2OUZ 2P15 2POG 2Q6J 2Q70 2QA6 2QA8 2QAB 2QE4 2QGT 2QGW 2QH6 2QR9 2QSE 2QXM 2QXS 2QZO 2R6W 2R6Y 3CBM 3CBO 3CBP 3DT3 3ERD 3ERT
Structure:
3ERT

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: