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Drug-Target Interaction

Drug

show drug details
PubChem ID:4510
Structure:
Synonyms:
1,2,3-Propanetriol trinatrate
1,2,3-Propanetriol, 1,2,3-trinitrate
1,2,3-Propanetriol, trinitrate
1,2,3-propanetrioltrinitrate
1,2,3-Propanetriyl nitrate
1,2,3-trinitrooxypropane
1,3-dinitrooxypropan-2-yl nitrate
105469-31-6
4-01-00-02762 (Beilstein Handbook Reference)
55-63-0
80066-48-4
8013-23-8
9010-02-0
AC1L1IBV
Adesitrin
Aldonitrin
Angibid
Anginine
Angiolingual
Angiplex
Anglix
Angonist
Angorin
Anogesic
Aquo-Trimitrosan
BIDD:GT0142
Blasting gelatin
Blasting oil
BRN 1802063
Buccal
Buccard
c0061
C07455
C3H5N3O9
Cardabid
Cardamist
Cardinit
Cardiodisco
CCRIS 4089
Cellegesic
CHEBI:28787
CHEMBL730
Chitamite
Colenitral
Corangin
Corangin Nitrokapseln
Cordipatch
Corditrine
Coro-Nitro
CPD-143
D00515
D005996
Dauxona
DB00727
Deponit
Deponit 5
Deponit TTS 10
Deponit TTS 5
Deponit-5
Diafusor
Discotrine
Dynamite
EINECS 200-240-8
Epinitril
Gepan Nitroglicerin
Gilucor nitro
Gilustenon
Glonoin
glycerin trinitrate
Glycerine trinitrate
Glycerintrinitrate
Glycerintrinitrate [Czech]
Glycerol (trinitrate de)
Glycerol (trinitrate de) [French]
Glycerol Nitric Acid Triester
Glycerol trinitrate
Glycerol(trinitrate de)
Glycerol(trinitrate de) [French]
Glycerol, nitric acid triester
Glyceroltrinitraat
Glyceroltrinitraat [Dutch]
Glyceryl
Glyceryl nitrate
Glyceryl trinitrate
Glycerylnitrat
Glytrin
GTN
GTN-Pohl
Herwicard
Herzer
HMS2094M15
HSDB 30
IMX-150
Klavikordal
Lenitral
Lentonitrina
LS-7741
MED-2002
Mi-Trates
Millisrol
Minitram
Minitran
Minitran (TN)
Minitro
Mionitrat
Mixture Name
MQX-503
Myocon
Myoglycerin
Myovin
Natispray
Neos nitro OPT
NG
Niglin
Niglycon
Niong
Niong Retard
Nirmin
Nit-Ret
Nitora
Nitradisc
Nitradisc Pad
Nitradisc TTS
Nitrangin
Nitrek
Nitric acid triester of gylcerol
Nitriderm
Nitriderm TTS
Nitrin
Nitrine
Nitrine-TDC
Nitro Bid
Nitro Dur
Nitro Dur TTS
NITRO IV
Nitro Mack Retard
Nitro Retard
Nitro Rorer
Nitro-Bid
Nitro-bid (TN)
Nitro-Dur
Nitro-dur (TN)
Nitro-Dur 10
Nitro-Dur 5
Nitro-Gesanit Retard
Nitro-lent
Nitro-M-Bid
Nitro-Mack Retard
Nitro-Par
Nitro-Pflaster
Nitro-Span
Nitro-Time
Nitroard
Nitrobaat
NitroBid
Nitrobid Oint
Nitrobukal
Nitrocap
NitrocapT.D
NitrocapT.D.
Nitrocard
Nitrocerin
Nitrocine
Nitrocine 5
Nitroclyn
Nitrocontin
Nitrocontin Continus
NitroCor
Nitrocot
Nitroderm
Nitroderm TTS
Nitroderm TTS Ext
Nitroderm TTS-5
Nitrodisc
NitroDur
Nitrodyl
Nitrodyl TTS
Nitrogard
Nitrogard-SR
Nitroglicerina
Nitroglicerina [Italian]
Nitroglicerina [Spanish]
Nitrogliceryna
Nitrogliceryna [Polish]
Nitroglin
Nitroglycerin
Nitroglycerin (JP15/USP)
Nitroglycerin (JP16/USP)
Nitroglycerin (NG)
NITROGLYCERIN IN DEXTROSE 5%
Nitroglycerin Injection
Nitroglycerin mixture with >2% but not >10% nitroglycerin, by mass, desensitized [UN3319] [Flammable solid]
Nitroglycerin mixture with >2% but not >10% nitroglycerin, by mass, desensitized [UN3319] [Flammable solid]
nitroglycerin ointment
Nitroglycerin [USAN:JAN]
Nitroglycerin, desensitized with not <40% non-volatile water insoluble phlegmatizer, by mass [UN0143] [Explosive 1.1D, Poison]
Nitroglycerin, liquid, not desensitized [Forbidden]
Nitroglycerin, solution in alcohol with > 5% but not > 10% nitroglycerin
Nitroglycerin, solution in alcohol, with >1% but not >10% nitroglycerin [UN0144] [Explosive 1.1D]
Nitroglycerin, solution in alcohol, with >1% but not >10% nitroglycerin [UN0144] [Explosive 1.1D]
Nitroglycerin, solution in alcohol, with >1% but not >5% nitroglycerin [UN3064] [Flammable liquid]
Nitroglycerin, solution in alcohol, with >1% but not >5% nitroglycerin [UN3064] [Flammable liquid]
Nitroglycerin, solution in alcohol, with not >1% nitroglycerin [UN1204]
Nitroglycerin, solution in alcohol, with not >1% nitroglycerin [UN1204] [Flammable liquid]
Nitroglycerin, solution in alcohol, with not >1% nitroglycerin [UN1204] [Flammable liquid]
Nitroglycerin, spirits of
Nitroglycerin-ACC
Nitroglycerine
Nitroglycerine [French]
Nitroglycerol
Nitroglyn
Nitroject
Nitrol
Nitrol (pharmaceutical)
Nitrol Ointment
Nitrolan
Nitroletten
Nitrolin
Nitrolingual
Nitrolingual Pump Spray
NITROLINGUAL PUMPSPRAY
Nitrolingual Spray
Nitrolowe
Nitromack Retard
Nitromel
Nitromex
Nitromint
Nitromint Aerosol
Nitromint Retard
Nitromist
Nitromist (TN)
NITRONAL
Nitronal Aqueous
Nitronet
Nitrong
Nitrong parenteral
Nitrong Retard
Nitrong-SR
Nitropatch
Nitropen
Nitropercuten
Nitroperlinit
Nitroplast
Nitroprol
Nitropront
Nitroprontan
NitroQuick
NitroQuik
Nitrorectal
Nitroretard
Nitrorex
Nitrospan
Nitrostabilin
Nitrostat
Nitrovis
Nitrozell retard
NK-843
NTG
NTS
Nysconitrine
Orthoderm
Percutol
Percutol Oint
Percutol Oint.
Perganit
Perglottal
Perlinganit
Plastranit
Polnitrin
propane-1,2,3-triyl trinitrate
Propanetriol trinitrate
Ratiopharm
RCRA waste no. P081
RCRA waste number P081
Rectogesic
SDM No. 17
SDM No. 27
SK-106N
SK-866
SK-878
SN2
Solution glyceryl trinitrate
Soup
Spirit of glonoin
Spirit of glyceryl trinitrate
Spirit of trinitroglycerin
Spirits of Nitroglycerin, (1 to 10%)
Susadrin
Suscard
Sustac
Sustak
Sustonit
Temponitrin
TNG
Top-Nitro
Transderm Nitro
Transderm-N TTS
Transderm-nitro
Transderm-nitro (TN)
Transderm-Nitro TTS
Transiderm-Nitro
Tridil
Tridil sublin
Trinalgon
Trinipatch
Triniplas
Trinitrate 1,2,3-propanetriol
Trinitrate, Glyceryl
Trinitrin
Trinitrin Tablets
Trinitrina Erba
Trinitrine Simple Laleuf
Trinitroglicerina Fabra
Trinitroglycerin
Trinitroglycerol
Trinitrol
Trinitrolong
Trinitron
Trinitrosan
Turicard
UN0143
UN0144
UN1204
UN3064
UN3319
UNII-G59M7S0WS3
Vascana
Vasoglyn
Vasolator
Vernies
Willong
ATC-Codes:
Side-Effects:
Side-EffectFrequency
headache0.49875003
lightheadedness0.057499997
syncope0.034999996
hypotension0.02572727
angina0.019999998
orthostatic hypotension0.0010
acute renal failure0.0010
pruritus0.0010
rash0.0010
eczema0.0010
blurred vision0.0010
vomiting0
burning sensation0
drug eruption0
mediastinal disorders0
vertigo0
paresthesia0
peripheral edema0
palpitations0
allergic reaction0
nausea0
heart disease0
increased sweating0
shock0
infection0
flushing0
sweating0
dermatitis0
exfoliative dermatitis0
erythema0
contact dermatitis0
weakness0
rhinitis0
agitation0
tachycardia0
stomatitis0
vascular disorders0
cerebral ischemia0
dizziness0
abdominal pain0
asthenia0
dyspnea0
pharyngitis0
methemoglobinemia0

Target

show target details
Uniprot ID:ALDH2_HUMAN
Synonyms:
Aldehyde dehydrogenase, mitochondrial
ALDH class 2
ALDH-E2
ALDHI
EC-Numbers:1.2.1.3
Organism:Homo sapiens
Human
PDB IDs:1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE
Structure:
2VLE

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----

References:

18786921
Partially irreversible inactivation of mitochondrial aldehyde dehydrogenase by nitroglycerin.. Matteo Beretta; Astrid Sottler; Kurt Schmidt; Bernd Mayer; Antonius C F Gorren (2008) The Journal of biological chemistry display abstract
Mitochondrial aldehyde dehydrogenase (ALDH2) may be involved in the biotransformation of glyceryl trinitrate (GTN), and the inactivation of ALDH2 by GTN may contribute to the phenomenon of nitrate tolerance. We studied the GTN-induced inactivation of ALDH2 by UV/visible absorption spectroscopy. Dehydrogenation of acetaldehyde and hydrolysis of p-nitrophenylacetate (p-NPA) were both inhibited by GTN. The rate of inhibition increased with the GTN concentration and decreased with the substrate concentration, indicative of competition between GTN and the substrates. Inactivation of p-NPA hydrolysis was greatly enhanced in the presence of NAD(+), and, to a lesser extent, in the presence of NADH. In the presence of dithiothreitol (DTT) inactivation of ALDH2 was much slower. Dihydrolipoic acid (LPA-H(2)) was less effective than DTT, whereas glutathione, cysteine, and ascorbate did not protect against inactivation. When DTT was added after complete inactivation, dehydrogenase reactivation was quite modest (< or =16%). The restored dehydrogenase activity correlated inversely with the GTN concentration but was hardly affected by the concentrations of acetaldehyde or DTT. Partial reactivation of dehydrogenation was also accomplished by LPA-H(2) but not by GSH. We conclude that, in addition to the previously documented reversible inhibition by GTN that can be ascribed to the oxidation of the active site thiol, there is an irreversible component to ALDH inactivation. Importantly, ALDH2-catalyzed GTN reduction was partly inactivated by preincubation with GTN, suggesting that the inactivation of GTN reduction is also partly irreversible. These observations are consistent with a significant role for irreversible inactivation of ALDH2 in the development of nitrate tolerance.
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