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Drug-Target Interaction

Drug

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PubChem ID:4495
Structure:
Synonyms:
4'-Nitro-2'-phenoxymethanesulfonanilide
4'-Nitro-2'-phenoxymethansulfonanilid
4-Nitro-2-phenoxy-methanesulfonanilide
4-NITRO-2-PHENOXYMETHANESULFONANILIDE
51803-78-2
AB00052332
AC-4524
AC1L1IAM
Alcala Brand of Nimesulide
Aldoron
Alter Brand of Nimesulide
Ambap693
Antifloxil
Aulin
BCBcMAP01_000034
Bio2_000382
Bio2_000862
BPBio1_000163
BRD-K76775527-001-06-2
BRN 2421175
BSPBio_000147
BSPBio_001103
BSPBio_003112
C012655
C13H12N2O5S
CAS-51803-78-2
CCG-39319
CCRIS 8225
CHEBI:44445
CHEMBL56367
D01049
DB04743
DivK1c_000693
EINECS 257-431-4
Ergha Brand of Nimesulide
Eskaflam
EU-0100855
Flogovital
Guaxan
Helsinn Brand of Nimesulide
HMS1362G05
HMS1568H09
HMS1792G05
HMS1922K17
HMS1990G05
HMS2089B14
HMS2095H09
HMS2234K19
HMS3262L11
HMS502C15
IDI1_000693
IDI1_002137
KBio1_000693
KBio2_000443
KBio2_002057
KBio2_003011
KBio2_004625
KBio2_005579
KBio2_007193
KBio3_000825
KBio3_000826
KBio3_002612
KBioGR_000443
KBioGR_000695
KBioSS_000443
KBioSS_002057
Lakeside Brand of Nimesulide
lizepat
Lopac-N-1016
Lopac0_000855
LS-90290
Maver Brand of Nimesulide
Mesulid
Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)-
Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- (9CI)
Methanesulfonanilide, 4'-nitro-2'-phenoxy-
MLS000069680
MLS001148268
MolPort-003-849-391
N 1016
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
N-[4-nitro-2-(phenoxy)phenyl]methanesulfonamide
N-[4-Nitro-2-phenoxyphenyl]-methanesulfonamide
N1016_SIGMA
NCGC00015725-01
NCGC00015725-02
NCGC00015725-03
NCGC00015725-04
NCGC00015725-05
NCGC00015725-06
NCGC00015725-07
NCGC00015725-08
NCGC00015725-09
NCGC00015725-10
NCGC00015725-11
NCGC00015725-12
NCGC00015725-13
NCGC00021842-03
NCGC00021842-04
NCGC00021842-05
NCGC00021842-06
NCGC00021842-07
NCGC00021842-08
nchembio.147-comp1
Nexen
NIM
NIM-03
Nimed
Nimedex
Nimesil
Nimesulida
Nimesulida [INN-Spanish]
NIMESULIDE
Nimesulide (JAN/INN)
Nimesulide [BAN:INN]
Nimesulidum
Nimesulidum [INN-Latin]
NINDS_000693
Nise Gel
Nisulid
Orthobid
Prestwick0_000194
Prestwick1_000194
Prestwick2_000194
Prestwick3_000194
Prestwick_618
R 805
R-805
Redaflam
SBB066407
SmithKline Beecham Brand of Nimesulide
SMR000058484
SPBio_001382
SPBio_002068
SPECTRUM1503231
Spectrum2_001541
Spectrum3_001576
Spectrum4_000178
Spectrum5_000964
Spectrum_001577
STL018679
Sulidene
Th?rabel Brand of Nimesulide
ATC-Codes:

Target

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Uniprot ID:Q62710_RAT
Synonyms:
Nitric oxide synthase
EC-Numbers:-
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

12507282
A COX-2 inhibitor, nimesulide, inhibits chemically-induced rat tongue carcinogenesis through suppression of cell proliferation activity and COX-2 and iNOS expression.. K Yoshida; T Tanaka; H Kohno; K Sakata; T Kawamori; H Mori; K Wakabayashi (2003) Histology and histopathology display abstract
The modifying effects of a cyclooxygenase (cox)-2 selective inhibitor nimesulide on tongue carcinogenesis were investigated in male F344 rats initiated with 4-nitroquinoline-1-oxide (4-NQO). The cell proliferation activity measured by proliferating cell nuclear antigen (PCNA)-positive index and apoptotic index, and the immunohistochemical expression of COX-2, and inducible nitric oxide synthase (iNOS) in the tongue mucosa or neoplasms were also examined for mechanistic analysis of modifying effects of nimesulide on tongue carcinogenesis. All animals except those treated with nimesulide alone and untreated rats were given 20 ppm 4-NQO in drinking water for 8 weeks to induce tongue neoplasms. Starting 1 week after the cessation of 4-NQO exposure, rats given 4-NQO were fed the experimental diets containing nimesulide (100 and 400 ppm) for 22 weeks. At week 32, the incidence of tongue squamous cell carcinoma was significantly reduced by feeding of the diet containing 400 ppm nimesulide. Feeding of nimesulide significantly decreased polyamine content and PCNA-labeling index in tongue carcinoma. Apoptotic index in tongue carcinoma was increased by feeding of nimesulide. In addition, nimesulide feeding reduced COX-2 and iNOS expression in the tongue dysplasia and neoplasms. These results suggest that 400 ppm nimesulide in diet, when given during the promotion phase, exerts chemopreventive ability against 4-NQO-induced tongue tumorigenesis through inhibition of cell proliferation activity in conjunction with modification of COX-2 and iNOS expression of the target lesions.