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Drug-Target Interaction

Drug

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PubChem ID:448537
Structure:
Synonyms:
"dibestrol ""2"" premix"
(E)-3,4-Bis(4-hydroxyphenyl)-3-hexene
(E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bisphenol
(E)-4,4'-(hex-3-ene-3,4-diyl)diphenol
(E)-alpha, alpha'-diethyl-4,4'-stilbened iol
(E)-alpha, alpha'-diethyl-4,4'-stilbenediol
(E)-Diethylstilbestrol
(Z)-4,4'-(1,2-Diethyl-1,2-ethylenediyl)bisphenol
.alpha.,.alpha.'-Diethyl-4,4'-stilbenediol
.alpha.,.alpha.'-Diethylstilbenediol
218944_ALDRICH
22610-99-7
3,4'(4,4'-Dihydroxyphenyl)hex-3-ene
3,4-bis(4-hydroxyphenyl)hex-3-ene
3,4-Bis(p-hydroxyphenyl)-3-hexene
3-Hexene,3,4-bis(p-hydroxyphenyl)-
4,4'-(1,2-Diethyl-1,2-ethenediyl)bisphenol
4,4'-(3E)-hex-3-ene-3,4-diyldiphenol
4,4'-Dihydroxy-.alpha.,.beta.-diethylstilbene
4,4'-dihydroxy-alph a,beta-diethylstilbene
4,4'-Dihydroxy-alpha,beta-diethylstilbene
4,4'-Dihydroxydiethylstilbene
4,4'-hex-3-ene-3,4-diyldiphenol
4,4'-Stilbenediol, .alpha.,.alpha.'-diethyl-
4,4'-Stilbenediol, .alpha.,.alpha.'-diethyl-, (E)-
4,4'-Stilbenediol, .alpha.,.alpha.-diethyl-
4,4'-Stilbenediol, 2,2'-diethyl-
4,4'-Stilbenediol, alpha,alpha'-diethyl-, (E)-
4,4'-Stilbenediol, alpha,alpha'-diethyl-, (E)- (8CI)
4,4'-Stilbenediol, alpha,alpha'-diethyl-, (Z)-
4-06-00-06856 (Beilstein Handbook Reference)
4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol
4-[(E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol
46207_FLUKA
46207_RIEDEL
56-53-1
63528-82-5
63528-82-5 (di-hydrochloride salt)
8026-45-7
8028-09-9
8030-34-0
8049-42-1
8053-00-7
AC1L9M2H
AC1Q2C9S
Acnestrol
AG-F-98604
Agostilben
AKOS005111142
alpha,alpha'-Diethyl-(E)-4,4'-stilbenediol
alpha,alpha'-diethyl-4,4'-stilbenediol
alpha,alpha'-Diethylstilbenediol
anti gestil
Antigestil
APS Brand of Diethylstilbestrol
Apstil
ARONIS23859
BIDD:ER0159
Bio-0854
Bio-des
BPBio1_000850
BRN 2056095
BSPBio_000772
BSPBio_002201
Bufon
C07620
C18H20O2
CCG-38961
CCRIS 240
CHEBI:41922
CHEMBL411
cis-alpha,alpha'-Diethyl-4,4'-stilbenediol
cis-Des
cis-Diethylstilbesterol
cis-Diethylstilbestrol
Climaterine
Co Pharma Brand of Diethylstilbestrol
Co-Pharma Brand of Diethylstilbestrol
Comestrol
Comestrol estrobene
component of Tylosterone
Cyren
Cyren A
D004054
D00577
D0526
D4628_SIGMA
Dawe's destrol
DB00255
DEB
DES
DES (synthetic estrogen)
Desma
Destrol
Di-Estryl
Diaethylstilboestrolum
Diastyl
Dibestrol
DiBestrol "2" Premix
Dibestrol '2' premix
DiBestrol 2 Premix
Dicorvin
Diethylstilbesterol
Diethylstilbestrol
diethylstilbestrol (DES)
DIETHYLSTILBESTROL (SEE ALSO TRANSGENIC MODEL EVALUATION
DIETHYLSTILBESTROL (SEE ALSO TRANSGENIC MODEL EVALUATION (DIETHYLSTILBESTROL))
Diethylstilbestrol (USP/INN)
Diethylstilbestrol BP
Diethylstilbestrol [Nonsteroidal oestrogens]
Diethylstilbestrol [USAN:INN]
Diethylstilbestrol, (Z)-Isomer
Diethylstilbestrol, Disodium Salt
Diethylstilbestrol, mixture of cis and trans
Diethylstilbestrol-Supplied by Selleck Chemicals
Diethylstilbestrolum
Diethylstilbestrolum [INN-Latin]
Diethylstilboesterol
diethylstilboestrol, DES, Stilbestrol, Agostilben, Diethylstilbestrol
Dietilestilbestrol
Dietilestilbestrol [INN-Spanish]
Dietilestilbestrol [Spanish]
Dietilstilbestrolo
Dietilstilbestrolo [DCIT]
Distilb?ne
Distilbene
Domestrol
Dyestrol
E-Diethylstilbestrol
EINECS 200-278-5
Estilbin ''MCO''
Estilbin MCO
estril
Estrobene
Estrogen
Estrogen, Stilbene
Estrogenine
Estromenin
Estrosyn
follidiene
Fonatol
Gerda Brand of Diethylstilbestrol
Grafestrol
Gynopharm
Hi-Bestrol
hibestrol
HMS1570G14
HMS1920G08
HMS2090C14
HMS2091M18
HMS2097G14
HMS2232N11
HMS501J21
HSDB 3060
I14-11699
IDI1_000519
Idroestril
Iscovesco
LS-146816
LS-220
Makarol
Menostar
Menostilbeen
MG 137
Micrest
Microest
Milestrol
MLS000028447
MLS002174252
MLS002222298
NCGC00090749-01
NCGC00090749-02
NCGC00090749-03
NCGC00090749-04
NCGC00090749-05
NCGC00090749-06
NCGC00090749-07
NCGC00090749-08
NCGC00090749-09
nchembio.140-comp1
nchembio.168-comp6
nchembio.76-comp3
neo-oe stranol 1
neo-Oestranol 1
Neo-Oestranol I
New-Estranol 1
NSC-3070
NSC3070
OeKolp
Oestrogenine
Oestrol vetag
oestrolmensil
Oestromenin
Oestromensil
Oestromensyl
Oestromienin
Oestromon
Pabestrol
Palestrol
Percutatrine oestrogenique iscovesco
Phenol 4,4'-(1,2-diethyl-1,2-ethenediyl)bis-, (E)-
Phenol, 4,4'-((1E)-1,2-diethyl-1,2-ethenediyl)bis-
Phenol, 4,4'-(1,2-diethyl-1,2-ethenediyl)bis-, (E)-
Phenol, 4,4'-(1,2-diethyl-1,2-ethylenediyl)bis-, (Z)-
Phenol, 4,4'-(1,2-diethyl-1,2-ethylenediyl)bis-, (Z)- (9CI)
Prestwick2_000756
Prestwick3_000756
Prestwick_1070
Protectona
RCRA waste no. U089
RCRA waste number U089
RGLYKWWBQGJZGM-ISLYRVAYSA-
Rumestrol 1
Rumestrol 2
S1859_Selleck
Sedestran
Serral
Sexocretin
Sibol
Sintestrol
SMR000058263
SPECTRUM1500244
Spectrum5_000799
ST IL
Stibilium
STIL
Stil-Rol
Stilbene Estrogen
Stilbestroform
Stilbestrol
Stilbestrol (TN)
Stilbestrol, diethyl-
Stilbestrone
Stilbetin
Stilboefral
Stilboestroform
Stilboestrol
Stilbofolin
stilbofollin
Stilbol
Stilkap
Stilphostrol
STK366318
STOCK1S-10082
strobene
Synestrin
Synthestrin
Synthoestrin
Synthofolin
Syntofolin
Tampovagan
Tampovagan stilboestrol
trans-.alpha.,.alpha.'-Diethyl-4,4'-stilbenediol
trans-.alpha.,.alpha.'-diethyl-4-4'-stilbenediol
trans-4,4 '-(1,2-diethyl-1,2-ethenediyl)bisphenol
trans-4,4'-(1,2-Diethyl-1,2-ethenediyl)bisphenol
trans-alpha,alpha'-diethyl-4,4'-stilbenediol
trans-Diethylstilbesterol
trans-Diethylstilbestrol
trans-Diethylstilboesterol
TRANS-DIETHYSTILBESTEROL
TRANSGENIC MODEL EVALUATION (DES)
Tylosterone
UNII-731DCA35BT
Vagestrol
WLN: QR DY2&UY2&R DQ
ZINC00001290
ATC-Codes:

Target

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Uniprot ID:ESR1_MOUSE
Synonyms:
ER
ER-alpha
Estradiol receptor
Estrogen receptor
Nuclear receptor subfamily 3 group A member 1
EC-Numbers:-
Organism:Mouse
Mus musculus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

16199072
Estrogenic compounds inhibit gap junctional intercellular communication in mouse Leydig TM3 cells.. Yumiko Iwase; Hideki Fukata; Chisato Mori (2006) Toxicology and applied pharmacology display abstract
Some estrogenic compounds are reported to cause testicular disorders in humans and/or experimental animals by direct action on Leydig cells. In carcinogenesis and normal development, gap junctional intercellular communication (GJIC) plays an essential role in maintaining homeostasis. In this study, we examine the effects of diethylstilbestrol (DES, a synthetic estrogen), 17beta-estradiol (E(2), a natural estrogen), and genistein (GEN, a phytoestrogen) on GJIC between mouse Leydig TM3 cells using Lucifer yellow microinjection. The three compounds tested produced GJIC inhibition in the TM3 cells after 24 h. Gradually, 10 microM DES began to inhibit GJIC for 24 h and this effect was observed until 72 h. On the other hand, both 20 microM E(2) and 25 microM GEN rapidly inhibited GJIC in 6 h and 2 h, respectively. The effects continued until 24 h, but weakened by 72 h. Furthermore, a combined effect at microM level between DES and E(2) on GJIC inhibition was observed, but not between GEN and E(2). DES and E(2) showed GJIC inhibition at low dose levels (nearly physiological estrogen levels) after 72 h, but GEN did not. DES-induced GJIC inhibition at 10 pM and 10 microM was completely counteracted by ICI 182,780 (ICl), an estrogen receptor antagonist. On the other hand, the inhibitory effects on GJIC with E(2) (10 pM and 20 microM) and GEN (25 microM) were partially blocked by ICI or calphostin C, a protein kinase C (PKC) inhibitor, and were completely blocked by the combination of ICI and calphostin C. These results demonstrate that DES inhibits GJIC between Leydig cells via the estrogen receptor (ER), and that E(2) and GEN inhibit GJIC via ER and PKC. These estrogenic compounds may have different individual non-genotoxic mechanism including PKC pathway on testicular carcinogenesis or development.