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Drug-Target Interaction

Drug

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PubChem ID:4485
Structure:
Synonyms:
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
101539-70-2
101554-38-5
2,6-Dimethyl-3,5-dicarbomethoxy-4-(2-nitrophenyl)-1,4-dihydropyridine
21829-25-4
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester (9CI)
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-, dimethyl ester (8CI)
4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester
4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester [German]
4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine
4-(2-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine
5-22-04-00268 (Beilstein Handbook Reference)
60299-11-8
Adalat
Adalat (TN)
Adalat 10
Adalat 20
Adalat 5
Adalat CC
Adalat CR
Adalat Crono
Adalat FT
Adalat GITS
Adalat GITS 30
Adalat LA
Adalat LP
Adalat Oros
Adalat PA
Adalat Retard
Adalat XL
Adalate
Adalate LP
Adapine
Adapress
Adcock Ingram Brand of Nifedipine
Adipine XL
Afeditab
Afeditab CR
Afeditab CR (TN)
AIDS-087985
AIDS087985
Alat
Aldipin
Alfadal
Alonix
Alonix S
Alpha-Nifedipine Retard
Angipec
Anifed
Anpine
Apo-Nifed
Aprical
Aprical long
AWD Pharma Brand of Nifedipine
BAY 1040
BAY A 1040
Bay-1040
BAY-a 1040
Bay-a-1040
Bay1040
BAYa1040
Bayer Brand of Nifedipine
BCBcMAP01_000046
BIM-0050796.0001
Bio1_000112
Bio1_000601
Bio1_001090
Bio2_000111
Bio2_000591
Bonacid
BPBio1_000271
BRN 0497773
BSPBio_000245
BSPBio_001391
BSPBio_002071
C07266
C17H18N2O6
Calcibloc
Calcigard
Calcilat
Camont
Cardifen
Cardilat
Cardilate
Cardionorm
CAS-21829-25-4
CBiol_001826
CCRIS 6074
CHEBI:7565
Chronadalate
Chronadalate LP
Citilat
cMAP_000042
Coracten
Coracten XL
Coral
Cordafen
Cordaflex
Cordalat
Cordicant
Cordilan
Cordipin
Cordipine
Corinfar
Corotrend
Corynphar
CPD000058291
D00437
D009543
DB01115
Depin
Dignokonstant
Dilafed
Dilcor
Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-3,5-pyridinedicarboxylate
Dimethyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate
dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Dimethyl 4-(2-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Dipinkor
DivK1c_000313
Duranifin
Ecodipi
Ecodipin
Ecodipin E
EINECS 244-598-3
Emaberin
EU-0100819
Fedcor
Fedcor Retard
Fenamon
Fenamon SR
Fenigidin
Fenihidin
Fenihidine
Fortipine LA
Glopir
Hadipin
Hexadilat
IDI1_000313
IDI1_033861
Infedipin
Introcar
KB-1712P
KBio1_000313
KBio2_000111
KBio2_001459
KBio2_002400
KBio2_002679
KBio2_004027
KBio2_004968
KBio2_005247
KBio2_006595
KBio2_007536
KBio3_000221
KBio3_000222
KBio3_001571
KBio3_002879
KBioGR_000111
KBioGR_000627
KBioGR_002400
KBioSS_000111
KBioSS_001459
KBioSS_002405
Kordafen
Korinfar
KRKA Brand of Nifedipine
Lopac-N-7634
Lopac0_000819
LS-1012
Macorel
Megalat
MLS000028521
MLS000758222
MLS001148146
MLS001401371
Monohydrochloride, Nifedipine
Myogard
N7634_SIGMA
NCGC00015748-01
NCGC00015748-02
NCGC00015748-03
NCGC00024983-01
NCGC00024983-02
NCGC00024983-03
NCGC00024983-04
NCGC00024983-05
NCGC00024983-06
NCGC00024983-07
NCGC00024983-08
NCGC00091707-01
nchembio.95-comp13
Nifangin
Nifecard
Nifecor
Nifediac
Nifedipine
Nifedipine (JP15/USP/INN)
Nifedipine Bayer Brand
Nifedipine GTIS
Nifedipine KRKA Brand
Nifedipine Monohydrochloride
Nifedipine Orion Brand
Nifedipine Pfizer Brand
Nifedipine [USAN:BAN:INN:JAN]
Nifedipine-GTIS
Nifedipino
Nifedipino [INN-Spanish]
Nifedipinum
Nifedipinum [INN-Latin]
Nifedipres
Nificard
NINDS_000313
Oprea1_788617
Orion Brand of Nifedipine
Orix
Oxcord
Pfizer Brand of Nifedipine
Pidilat
Prestwick0_000063
Prestwick1_000063
Prestwick2_000063
Prestwick3_000063
Prestwick_357
Procardia
Procardia (TN)
Procardia XL
SAM001246963
SBB012573
Sepamit
Slofedipine XL
SMR000058291
SPBio_001016
SPBio_002166
SPECTRUM1500431
Spectrum2_001058
Spectrum3_000516
Spectrum4_000074
Spectrum5_001278
Spectrum_000979
Tensipine MR
Tibricol
Tocris-1075
Vascard
Zenusin
ZINC19594578
ATC-Codes:
Side-Effects:
Side-EffectFrequency
insomnia0.0010
jaundice0.0010
nausea0.0010
palpitations0.0010
pulmonary oedema0.0010
shock0.0010
stevens - johnson syndrome0.0010
tachycardia0.0010
bradyarrhythmias0.0010
peripheral edema0.0010
ischemic heart disease0.0010
metabolic acidosis0.0010
hypoxia0.0010
chronic renal insufficiency0.0010
bradycardia0.0010
increase in blood pressure0.0010
hypotension0.0010
hyperglycemia0.0010
hepatitis0.0010
anaphylaxis0.0010
hemolytic anemia0.0010
angioedema0.0010
anxiety0.0010
cardiac arrhythmia0.0010
asthenia0.0010
coma0.0010
constipation0.0010
exfoliative dermatitis0.0010
bleeding0.0010
headache0.0010
gynecomastia0.0010
gastrointestinal bleeding0.0010
edema0.0010
dyspepsia0.0010
dizziness0.0010
sweating0
pelvic pain0
phlebitis0
dysphagia0
migraine0
muscle cramps0
polyuria0
eosinophilia0
somnolence0
erythema multiforme0
rhinitis0
amnesia0
dermatitis0
urinary frequency0
gout0
weight gain0
rash0
eructation0
weakness0
paresthesia0
bronchospasm0
hematuria0
congestive heart failure0
nervousness0
cardiac arrest0
weight loss0
toxic epidermal necrolysis0
arthrosis0
vomiting0
petechiae0
heartburn0
myalgia0
shortness of breath0
arthralgia0
upper respiratory tract infection0
menstrual disorder0
arthritis0
melena0
leg cramps0
increased sweating0
postural hypotension0
nasal congestion0
lightheadedness0
cough0
epistaxis0
thrombocytopenia0
amblyopia0
laboratory test abnormal0
wheezing0
abdominal pain0
dyspnea0
abnormal vision0
giddiness0
allergic reaction0
lymphadenopathy0
urticaria0
dry mouth0
anemia0
chest pain0
gastroesophageal reflux0
gum hemorrhage0
giddiness0
decreased libido0
syncope0
alopecia0
photosensitivity0
pruritus0
chest pain substernal0
back pain0
diplopia0
fever0
joint stiffness0
myocardial infarction0
cellulitis0
esophagitis0
confusion0
leg pain0
urinary incontinence0
blindness0
atrial fibrillation0
kidney calculus0
flushing0
ataxia0
pharyngitis0
fatigue0
nocturia0
vertigo0
diarrhea0
tinnitus0
dysuria0
tremor0
hot flashes0
breast pain0
impotence0
nightmares0
leukopenia0
stridor0
sore throat0
conjunctivitis0
sinusitis0
blurred vision0
chills0
purpura0
neck pain0
flatulence0
hypersensitivity0
malaise0

Target

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Uniprot ID:CAC1S_HUMAN
Synonyms:
Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle
Voltage-dependent L-type calcium channel subunit alpha-1S
Voltage-gated calcium channel subunit alpha Cav1.1
EC-Numbers:-
Organism:Homo sapiens
Human
PDB IDs:2VAY
Structure:
2VAY

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: