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Drug-Target Interaction

Drug

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PubChem ID:4463
Structure:
Synonyms:
"birg 0587;bi-rg-587"
1-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido [3,2-b:2',3'-e][1,4] diazepin-6-one
11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one
11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one & PRO 140 (Anti-CCR5 monoclonal antibody)
11-cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one
11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
129618-40-2
1vrt
2hny
5H-Dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one, 5,11-dihydro-11-cyclopropyl-4-methyl-
6H-Dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one,
6H-Dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-methyl-
AIDS-001856
AIDS-005653
AIDS-415078
AIDS001856
AIDS005653
AIDS415078
BB_SC-1873
BI RG 587
BI-RG-587
BI-RG-587 & CD4-IgG
BIRG 0587
BIRG 0587;BI-RG-587
BIRG 587
BIRG-0587
BIRG-587
BIRG587
C07263
C15H14N4O
Cahill May Roberts Brand of Nevirapine
CPD000048458
D00435
D019829
DB00238
DRG-0116
HSDB 7164
LS-2289
MLS000084585
MLS000759409
MLS001055309
MLS001201730
N11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one & CD4-immunoadhesin
NCGC00065890-02
NEV
Nevirapine
Nevirapine & CD4-IgG
Nevirapine (JAN/USP/INN)
Nevirapine [USAN:INN]
Nevirapine+PRO 140
NON-NUCLEOSIDE RT INHIBITOR NEVIRAPINE
NSC 641530
NSC641530
NVP
Promeco Brand of Nevirapine
SAM001246551
SMR000048458
Viramune
Viramune (TN)
ZINC00004778
ATC-Codes:
Side-Effects:
Side-EffectFrequency
allergic reactions0.0010
hypersensitivity0.0010
jaundice0.0010
neutropenia0.0010
paraesthesia0.0010
stevens - johnson syndrome0.0010
ulcerative stomatitis0.0010
urticaria0.0010
vomiting0.0010
hepatic failure0.0010
hepatic necrosis0.0010
drug withdrawal0.0010
general malaise0.0010
lymphadenopathy0.0010
hepatitis0.0010
fever0.0010
granulocytopenia0.0010
anaphylaxis0.0010
anemia0.0010
angioedema0.0010
arthralgia0.0010
blistering0.0010
conjunctivitis0.0010
constitutional findings0.0010
fatigue0.0010
rash0.0010
toxic epidermal necrolysis0.0010
eosinophilia0.0010
edema0.0010
somnolence0.0010
exfoliative dermatitis0
liver function tests abnormal0
diarrhea0
nausea0
myalgia0
chronic hepatitis0
rhabdomyolysis0
hepatitis infectious0
abdominal pain0
hepatitis b0
pruritus0
liver disease0
ulcer0
thrombocytopenia0
erythema multiforme0
erythema0
headache0

Target

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Uniprot ID:POL_HV1H2
Synonyms:
Gag-Pol polyprotein
Pr160Gag-Pol
EC-Numbers:-
Organism:HIV-1
Human immunodeficiency virus type 1
isolate HXB2 group M subtype B
PDB IDs:1A30 1BV7 1BV9 1BVE 1BVG 1BWA 1BWB 1C0T 1C0U 1C1B 1C1C 1DMP 1DTQ 1DTT 1E6J 1EP4 1ESK 1EX4 1EXQ 1FB7 1FK9 1FKO 1FKP 1G6L 1HIV 1HVH 1HVR 1HWR 1HXB 1JKH 1JLA 1JLB 1JLC 1JLE 1JLF 1JLG 1JLQ 1KLM 1LV1 1LW0 1LW2 1LWC 1LWE 1LWF 1NCP 1O1W 1ODW 1ODY 1QBR 1QBS 1QBT 1QBU 1REV 1RT1 1RT2 1RT3 1RT4 1RT5 1RT6 1RT7 1RTD 1RTH 1RTI 1RTJ 1S1T 1S1U 1S1V 1S1W 1S1X 1T05 1TAM 1TKT 1TKX 1TKZ 1TL1 1TL3 1VRT 1VRU 2HND 2HNY 2HNZ 2NPH 2OPP 2OPQ 2OPR 2OPS 2RF2 2RKI 3C6T 3C6U 3DI6 3DLE 3DLG 3DM2 3DMJ 3DOK 3DOL 3DOX 3DRP 3DRR 3DRS 3DYA 3E01 3I0R 3I0S 3PHV
Structure:
3PHV

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: