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Drug-Target Interaction

Drug

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PubChem ID:445629
Structure:
Synonyms:
(+)-Thiolactomycin
(4-R)(2E,5E)-2,4,6-Trimethyl-3-hydroxy-2,5,7-octatriene-4-thiolide
(5R)-4-Hydroxy-3,5-dimethyl-5-[(1E)-2-methyl-1,3-butadienyl]-2(5H)-thiophenone
(R)-(+)-Thiolactomycin
(R-(E))-3,5-Dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-2(5H)-- thiophenone
(R-(E))-3,5-Dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-2(5H)-thiopheno
(R-(E))-3,5-Dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone
1fj4
2(5H)-Thiophenone, 3,5-dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-, (R-(E))-
2(5H)-Thiophenone, 4-hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-, (S-(E))-
2vb8
4-HYDROXY-3,5-DIMETHYL-5-(2-METHYL-BUTA-1,3-DIENYL)-5H-THIOPHEN-2-ONE
82079-32-1
82079-32-1 (R-ISOMER)
AIDS-054283
AIDS054283
Antibiotic 2-200
BRN 4423670
C11165
C11H14O2S
EU-0100908
Lopac0_000908
LS-153230
NCGC00094221-01
NCGC00094221-02
T9567_SIGMA
Thiolactomycin
TLM
[R-(E)]-4-Hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone

Target

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Uniprot ID:FABH_ECOLI
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase 3
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
EcFabH
KAS III
EC-Numbers:2.3.1.180
Organism:Escherichia coli
strain K12
PDB IDs:1EBL 1HN9 1HND 1HNH 1HNJ 1HNK 1MZS 2EFT 2GYO 3IL9
Structure:
3IL9

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
-121000--

References: