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Drug-Target Interaction

Drug

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PubChem ID:445154
Structure:
Synonyms:
"trans-3,4′,5-trihydroxystilbene"
(E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
(E)-5-(p-Hydroxystyryl)resorcinol
(E)-5-[2-(4-hydroxyphenyl)ethenyl]-1,3-benzendiol
(E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol
(E)-resveratrol
1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (E)-
1,3-Benzenediol, 5-(2-(4-hydroxyphenyl)ethenyl)-, (E)-;
3,4',5-Stilbenetriol
3,4',5-trihydroxy-stilbene
3,4',5-Trihydroxy-trans-stilbene
3,4',5-Trihydroxystilbene
3,5,4'-Trihydroxy-trans-stilbene
3,5,4'-Trihydroxystilbene
3,5-Dihydroxy-4'-methoxystilbene
31100-06-8
31100-06-8 (DELETED)
34092_FLUKA
34092_RIEDEL
5-((1E)-2-(4-Hydroxyphenyl)ethenyl)-1,3-benzenediol
5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol
5-[(1E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
5-[(1E)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol
5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
5-[(E)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol
5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
501-36-0
533C1DA0-4104-42B5-9D32-9265F40857E4
AC-727
AC1L9HIC
AIDS-025474
AIDS025474
BB_NC-2570
BPBio1_000479
BRD-K25591257-001-01-2
BRD-K80738081-001-06-2
BRD-K80738081-001-10-4
BSPBio_000435
BSPBio_001114
BSPBio_003461
C03582
C059514
C14H12O3
CCG-38874
CCRIS 8952
CHEBI:27881
CHEBI:45713
CHEMBL165
CPD-83
CPD000058206
CU-01000001503-3
DB02709
EU-0101111
FT-0082623
HMS1362H15
HMS1569F17
HMS1792H15
HMS1921N04
HMS1990H15
HMS2052I09
HMS2096F17
HMS2232A18
HMS3263O04
HSDB 7571
I06-0437
IDI1_002152
KSC-10-164
KUC104385N
LMPK13090005
Lopac0_001111
LS-2146
LUKBXSAWLPMMSZ-OWOJBTEDSA-
MLS000069735
MLS001055357
MLS001076538
MLS002207121
MLS002222231
MolPort-002-499-801
NCGC00017352-05
NCGC00017352-06
NCGC00017352-07
NCGC00017352-08
NCGC00017352-09
NCGC00017352-10
NCGC00017352-11
NCGC00017352-12
NCGC00017352-13
NCGC00017352-14
NCGC00017352-15
NCGC00017352-16
NCGC00017352-17
NCGC00017352-18
NCGC00017352-19
NCGC00024003-00
NCGC00024003-04
NCGC00024003-05
NCGC00024003-06
NCGC00024003-07
NCGC00024003-08
NCGC00024003-09
NCGC00024003-10
NCGC00024003-11
NCGC00024003-12
NCGC00024003-13
NCGC00024003-14
nchembio.140-comp2
nchembio.281-comp10
NSC 327430
NSC327430
Prestwick2_000508
Prestwick3_000508
Prestwick_619
PREVENTION 8 (RESVERATROL)
R 5010
R0071
R5010_SIGMA
Resveratrol
Resveratrol, E-
resveratrol-3-sulfate
Resveratrol-Supplied by Selleck Chemicals
Resvida
RM-1812
RV
S1396_Selleck
SAM001246888
SDCCGMLS-0002998.P003
SGCUT00007
SMR000058206
SPECTRUM1502223
Spectrum5_000552
SRT 501
SRT-501
SRT501
ST057251
STL
TL8003323
to_000079
trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene
trans-3,4′,5-Trihydroxystilbene
trans-3,4',5-trihydroxystilbene
trans-Resveratrol
ZINC00006787

Target

show target details
Uniprot ID:ICE_DROME
Synonyms:
Caspase
drICE
EC-Numbers:3.4.22.-
Organism:Drosophila melanogaster
Fruit fly
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

14977434
Antiproliferative effect of resveratrol in human prostate carcinoma cells.. Young-Ae Kim; Sook-Hee Rhee; Kun-Young Park; Yung Hyun Choi (2003) Journal of medicinal food display abstract
Resveratrol, a polyphenolic phytoalexin found in grapes, may have potential for the prevention and treatment of human cancer. We report here that resveratrol inhibits the growth of human prostate carcinoma DU145 cells and provide a molecular explanation of the effect. Resveratrol treatment in DU145 cells resulted in a dose-dependent inhibition of cell growth and induced apoptotic cell death. The antiproliferative effect of resveratrol was associated with the inhibition of D-type cyclins and cyclin-dependent kinase (Cdk) 4 expression, and the induction of tumor suppressor p53 and Cdk inhibitor p21. Moreover, the kinase activities of cyclin E and Cdk2 were inhibited by resveratrol without alteration of their protein levels. Resveratrol treatment also up-regulated the Bax protein and mRNA expression in a dose-dependent manner; however, Bcl-2 and Bcl-xL levels were not significantly affected. These effects were found to correlate with an activation of caspase-3 and caspase-9. Taken together, our study suggests that resveratrol has a strong potential for development as an agent for the prevention of human prostate cancer.