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Drug-Target Interaction

Drug

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PubChem ID:443388
Structure:
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benz
(S)-2-[(1-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-phenyl}-methanoyl)-amino]-pentanedioic acid
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID
AC1L9EKK
AIDS-106597
AIDS106597
C11737
CB3
CB3717
CHEBI:41452
CHEBI:474002
CHEMBL389051
DB03541
PDDF
TCMDC-131823

Target

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Uniprot ID:TYSY_HUMAN
Synonyms:
Thymidylate synthase
TS
TSase
EC-Numbers:2.1.1.45
Organism:Homo sapiens
Human
PDB IDs:1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EGY 3EHI
Structure:
3EHI

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--36-
--37-
7.0---
--55-
10---
--72-
--85-
--100-
--100-
--150-
30---
3e+1---
--1500-
--5000-
20000---

References: