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Drug-Target Interaction

Drug

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PubChem ID:443388
Structure:
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benz
(S)-2-[(1-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-phenyl}-methanoyl)-amino]-pentanedioic acid
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID
AC1L9EKK
AIDS-106597
AIDS106597
C11737
CB3
CB3717
CHEBI:41452
CHEBI:474002
CHEMBL389051
DB03541
PDDF
TCMDC-131823

Target

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Uniprot ID:TYSY_ECOLI
Synonyms:
Thymidylate synthase
TS
TSase
EC-Numbers:2.1.1.45
Organism:Escherichia coli
strain K12
PDB IDs:1AIQ 1AJM 1AN5 1AOB 1AXW 1BDU 1BID 1BJG 1BQ1 1BQ2 1DDU 1DNA 1EV5 1EV8 1EVF 1EVG 1F4B 1F4C 1F4D 1F4E 1F4F 1F4G 1FFL 1FWM 1JG0 1JTQ 1JTU 1JUT 1KCE 1KZI 1KZJ 1NCE 1QQQ 1SYN 1TDU 1TJS 1TLC 1TLS 1TRG 1TSD 1TSN 1TYS 1ZPR 2A9W 2BBQ 2FTN 2FTO 2FTQ 2G8M 2G8O 2G8X 2KCE 2TSC 2VET 2VF0 3B5B 3B9H 3BFI 3BGX 3BHL 3BHR 3TMS
Structure:
3TMS

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: