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Drug-Target Interaction

Drug

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PubChem ID:443388
Structure:
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benz
(S)-2-[(1-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-phenyl}-methanoyl)-amino]-pentanedioic acid
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID
AC1L9EKK
AIDS-106597
AIDS106597
C11737
CB3
CB3717
CHEBI:41452
CHEBI:474002
CHEMBL389051
DB03541
PDDF
TCMDC-131823

Target

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Uniprot ID:DYR_HUMAN
Synonyms:
Dihydrofolate reductase
EC-Numbers:1.5.1.3
Organism:Homo sapiens
Human
PDB IDs:1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 3EIG 3F8Y 3F8Z 3F91 3FS6 3GHC 3GHV 3GHW
Structure:
3GHW

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--1900-

References: