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Drug-Target Interaction

Drug

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PubChem ID:443388
Structure:
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benz
(S)-2-[(1-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-phenyl}-methanoyl)-amino]-pentanedioic acid
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID
AC1L9EKK
AIDS-106597
AIDS106597
C11737
CB3
CB3717
CHEBI:41452
CHEBI:474002
CHEMBL389051
DB03541
PDDF
TCMDC-131823

Target

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Uniprot ID:DYR_ECOLI
Synonyms:
Dihydrofolate reductase
EC-Numbers:1.5.1.3
Organism:Escherichia coli
strain K12
PDB IDs:1DDR 1DDS 1DHI 1DHJ 1DRA 1DRB 1DRE 1DRH 1DYH 1DYI 1DYJ 1JOL 1JOM 1RA1 1RA2 1RA3 1RA8 1RA9 1RB2 1RB3 1RC4 1RD7 1RE7 1RF7 1RG7 1RH3 1RX1 1RX2 1RX3 1RX4 1RX5 1RX6 1RX7 1RX8 1RX9 1TDR 2ANO 2ANQ 2D0K 2DRC 2INQ 3DAU 3DRC 4DFR 5DFR 6DFR 7DFR
Structure:
7DFR

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--23000-

References: