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Drug-Target Interaction

Drug

show drug details
PubChem ID:4205
Structure:
Synonyms:
(1)-1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine
1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine
1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
2-Methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepin
2-methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
6-Azamianserin
61337-67-5
85650-52-8
Azamianserin
C07570
CHEBI:6950
CPD000466347
D00563
DB00370
EINECS 288-060-6
LS-127703
LS-185067
M0443_SIGMA
ME-2040
Mepirzapin
Mepirzepine
Mirtazapina
Mirtazapina [INN-Spanish]
Mirtazapine
Mirtazapine (JAN/USAN/INN)
Mirtazapine [USAN:BAN:INN]
Mirtazapine [USAN:INN:BAN]
Mirtazapinum
Mirtazapinum [INN-Latin]
Mirtazepine
Mirtazipine
MLS000759460
MLS001076676
NCGC00025346-02
ORG 3770
Org-3770
PDSP1_001529
PDSP2_001513
Promyrtil
Pyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-
Pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-
Remergil
Remergon
Remeron
Remeron (TN)
Remeron SolTab
Rexer
SAM001246659
SMR000466347
Zispin
ATC-Codes:
Side-Effects:
Side-EffectFrequency
abdominal pain1.0
urinary tract infection1.0
sinusitis1.0
arthralgia1.0
vertigo1.0
anorexia1.0
cough1.0
pruritus1.0
malaise1.0
rash1.0
amnesia1.0
hypertension1.0
agitation0.66700006
anxiety0.66699994
paresthesia0.6555172
vomiting0.42370975
somnolence0.31457892
dry mouth0.23095238
constipation0.11857144
weight gain0.08071428
asthenia0.07428571
flu syndrome0.04619048
dizziness0.04026317
back pain0.01809524
urinary frequency0.018095238
myalgia0.018095236
peripheral edema0.018095236
tremor0.012580646
confusion0.011290319
bradycardia0.010000002
hypotension0.010000002
syncope0.010000002
migraine0.010000002
ventricular extrasystoles0.010000002
glaucoma0.010000002
exfoliative dermatitis0.010000002
colitis0.010000002
vaginitis0.010000002
cholecystitis0.010000002
myocardial infarction0.010000002
angina pectoris0.010000002
dehydration0.010000002
photosensitivity0.010000002
neck rigidity0.010000001
hallucinations0.010000001
hematuria0.010000001
chills0.010000001
hyperacusis0.010000001
tenosynovitis0.010000001
lacrimation disorder0.010000001
pneumonia0.010000001
kidney calculus0.010000001
weight loss0.010000001
keratoconjunctivitis0.010000001
urinary retention0.010000001
urinary incontinence0.010000001
impotence0.010000001
neurosis0.010000001
breast pain0.010000001
liver function tests abnormal0.010000001
fever0.010000001
dysuria0.010000001
asthma0.010000001
dysmenorrhea0.010000001
dyskinesia0.010000001
dysarthria0.010000001
ataxia0.010000001
delirium0.010000001
bronchitis0.010000001
cystitis0.010000001
neck pain0.010000001
ear pain0.010000001
arthritis0.010000001
amenorrhea0.010000001
glossitis0.010000001
gum hemorrhage0.010000001
alopecia0.010000001
eye pain0.010000001
herpes simplex0.010000001
conjunctivitis0.010000001
acne0.010000001
dry skin0.010000001
eructation0.010000001
epistaxis0.010000001
dermatitis0.01
coma0.01
ulcer0.009666668
stomatitis0.00959091
nausea0.008152172
dyspnea0.008095238
edema0.006246571
deafness0.0052244915
hiccup0.0010
bone pain0.0010
chest pain substernal0.0010
sweating0.0010
drug dependence0.0010
skin ulcer0.0010
cerebral ischemia0.0010
thrombocytopenia0.0010
sgot increased0.0010
paralysis0.0010
urinary urgency0.0010
bigeminy0.0010
urticaria0.0010
dementia0.0010
lymphadenopathy0.0010
vascular headache0.0010
urethritis0.0010
granulocytopenia0.0010
gastritis0.0010
gastroenteritis0.0010
goiter0.0010
gout0.0010
headache0.0010
cardiomegaly0.0010
heart failure0.0010
herpes zoster0.0010
breast enlargement0.0010
pathologic fracture0.0010
fatigue0.0010
grand mal convulsion0.0010
anemia0.0010
aplastic anemia0.0010
aphasia0.0010
blepharitis0.0010
bursitis0.0010
oral moniliasis0.0010
cellulitis0.0010
diabetes mellitus0.0010
diplopia0.0010
salivary gland enlargement0.0010
hypothyroidism0.0010
pancreatitis0.0010
pancytopenia0.0010
petechia0.0010
phlebitis0.0010
pneumothorax0.0010
polyuria0.0010
pulmonary embolus0.0010
increased salivation0.0010
shock0.0010
otitis media0.0010
osteoporosis0.0010
arthrosis0.0010
laryngitis0.0010
leukopenia0.0010
cirrhosis of liver0.0010
lymphocytosis0.0010
menorrhagia0.0010
metrorrhagia0.0010
myositis0.0010
nystagmus0.0010
seborrhea0.0010
aphthous stomatitis0.001
arrhythmia0.001
neutropenia0
amblyopia0
laboratory test abnormal0
dyspepsia0
postural hypotension0
stupor0
manic0
thinking abnormal0
depersonalization0
emotional lability0
apathy0
delusions0
euphoria0
rhinitis0
infection0
chest pain0
als0
pain0
decreased libido0
flatulence0
pharyngitis0
diarrhea0
tinnitus0
hypercholesterolemia0
nervousness0
tachycardia0
palpitations0
seizures0

Target

show target details
Uniprot ID:CP2C8_HUMAN
Synonyms:
CYPIIC8
Cytochrome P450 2C8
P450 form 1
P450 IIC2
P450 MP-12/MP-20
S-mephenytoin 4-hydroxylase
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:1PQ2 2NNH 2NNI 2NNJ 2VN0
Structure:
2VN0

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: