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Drug-Target Interaction

Drug

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PubChem ID:4197
Structure:
Synonyms:
"1,6-dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile"
(3,4'-BIPYRIDINE)-5-CARBONITRILE, 1,6-DIHYDRO-2-METHYL-6-OXO-
(3,4'-Bipyridine)-5-carbonitrile, 6-dihydro-2-methyl-6-oxo-
1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile
111GE027
2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone
6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile
78415-72-2
AB00514027
AC-4730
AC1L1HMP
AC1Q2EBX
Ambap5086
BIDD:GT0197
BPBio1_001156
BRN 3546821
BSPBio_001050
C07224
C12H9N3O
CAS-78415-72-2
CCG-101020
CCG-204822
CCRIS 3795
CHEBI:50693
CHEMBL189
Corotrop
Corotrope
CPD000058475
D00417
DB00235
EINECS 278-903-6
EN002063
EU-0100737
HMS1571E12
HMS2051L10
HMS2090J14
HMS2098E12
HMS2234A23
HMS3262C16
I06-0259
Lopac-M-4659
Lopac0_000737
LS-44610
M 4659
M1663
M4659_SIGMA
Milrila
Milrila (TN)
Milrinona
Milrinona [Spanish]
Milrinone
Milrinone (JAN/USAN/INN)
Milrinone Lactate
MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER
Milrinone [USAN:BAN:INN]
Milrinone, Primacor
Milrinone-Supplied by Selleck Chemicals
Milrinonum
Milrinonum [Latin]
MLS000028818
MLS001424052
NCGC00015675-01
NCGC00015675-02
NCGC00015675-03
NCGC00015675-04
NCGC00015675-05
NCGC00015675-06
NCGC00015675-07
NCGC00015675-08
NCGC00015675-09
NCGC00025189-01
NCGC00025189-02
NCGC00025189-03
NCGC00164390-01
Prestwick0_001065
Prestwick1_001065
Prestwick2_001065
Prestwick3_001065
Primacor
PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER
S2484_Selleck
SAM001246611
SBB055743
SMR000058475
SPBio_002965
Tocris-1504
UNII-JU9YAX04C7
WIN 47203-2
Win-47203
Win-47203-2
YM 018
ZINC09224016
ATC-Codes:
Side-Effects:
Side-EffectFrequency
anaphylactic shock0.0010
tremor0.0010
thrombocytopenia0.0010
hypokalemia0.0010
headaches0.0010
rash0.0010
bronchospasm0.0010
ventricular tachycardia0
hypotension0
shock0
angina pectoris0
chest pain0
tachycardia0
ventricular fibrillation0

Target

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Uniprot ID:PDE5A_HUMAN
Synonyms:
CGB-PDE
cGMP-binding cGMP-specific phosphodiesterase
cGMP-specific 3',5'-cyclic phosphodiesterase
EC-Numbers:3.1.4.35
Organism:Homo sapiens
Human
PDB IDs:1RKP 1T9R 1T9S 1TBF 1UDT 1UDU 1UHO 1XOZ 1XP0 2CHM 2H40 2H42 2H44 3B2R 3BJC 3HC8 3HDZ
Structure:
3HDZ

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--110000-

References: