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Drug-Target Interaction

Drug

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PubChem ID:4114
Structure:
Synonyms:
10-32-2
12692-94-3
298-81-7
5-19-06-00015 (Beilstein Handbook Reference)
5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, .delta.-lactone
5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone
6-Hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactone
7-furocoumarin
7H-Furo(3,2-g)(1)benzopyran-7-one, 9-methoxy-
7H-Furo[3,2-g][1]benzopyran-7-one, 9-methoxy-
8 Methoxypsoralen
8 MOP
8-Methoxy
8-Methoxy(furano-3'.2':6.7-coumarin)
8-Methoxy-(furano-3'.2':6.7-coumarin)
8-Methoxy-2',3',6,7-furocoumarin
8-Methoxy-4',5',6,7-furocoumarin
8-methoxy-4',5':6,7-furocoumarin
8-Methoxy-[furano-3'.2':6.7-coumarin]
8-Methoxyfuranocoumarin
8-methoxyfuranocoumarins
8-methoxyfurocoumarins
8-Methoxypsoralen
8-METHOXYPSORALEN + UVA (SEE ALSO C55903)
8-Methoxypsoralen with ultraviolet A therapy
8-Methoxypsoralene
8-MOP
8-MOP Capsules
8-MP
8MO
8MOP
9-(methyloxy)-7H-furo[3,2-g]chromen-7-one
9-metho xy-7H-furo(3,2-g)benzopyran-7-one
9-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one
9-Methoxy-7H-furo(3,2-g)benzopyran-7-one
9-methoxy-7H-furo[3,2-g]chromen-7-one
9-METHOXY-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE
9-methoxyfurano[3,2-g]chromen-2-one
9-Methoxyfuro(3,2-g)chromen-7-one
9-methoxyfuro[3,2-g]chromen-7-one
9-Methoxyfuro[3,2-g][1]benzopyran-7-one
9-Methoxypsoralen
A1783/0075596
AC-4259
AC1L1HFY
ACon1_000174
AIDS-001590
AIDS001590
AKOS000277012
Ammodin
Ammoidin
an 8-methoxyfurocoumarin
Boehringer Ingelheim Brand of Methoxsalen
BPBio1_000680
BRD-K63430059-001-03-2
BRD-K63430059-001-06-5
BRN 0196453
BSPBio_000618
BSPBio_001997
C01864
C12H8O4
Canderm Brand of Methoxsalen
CAS-298-81-7
CCG-36366
CCRIS 2083
CHEBI:18358
CHEBI:52028
CHEMBL416
Chinoin Brand of Methoxsalen
CPD-13042
CPD000071170
D00139
D008730
DB Brand of Methoxsalen
DB00553
Delta Brand of Methoxsalen
Deltasoralen
Dermatech Brand of Methoxsalen
Dermox
DivK1c_000763
DRG-0088
EINECS 206-066-9
FT-0082222
Galderma Brand of Methoxsalen
Geroxalen
HMS1569O20
HMS1920N05
HMS2091D20
HMS2096O20
HMS2269P03
HMS3259L13
HMS502G05
HSDB 2505
I06-0695
ICN Brand 1 of Methoxsalen
ICN Brand 2 of Methoxsalen
ICN Brand 3 of Methoxsalen
IDI1_000763
Jsp005650
KBio1_000763
KBio2_001503
KBio2_004071
KBio2_006639
KBio3_001497
KBioGR_000543
KBioSS_001503
LS-68
M3501_FLUKA
M3501_SIAL
M?ladinine
MEGxp0_000095
Meladinin
Meladinin (VAN)
Meladinina
Meladinine
Meladoxen
Meloxine
Methoxa Dome
Methoxa-Dome
Methoxalen
Methoxaten
Methoxsalen
Methoxsalen (JP15/USP)
Methoxsalen (JP16/USP)
Methoxsalen Canderm Brand
Methoxsalen Chinoin Brand
Methoxsalen Delta Brand
Methoxsalen Dermatech Brand
Methoxsalen Mex-America Brand
Methoxsalen plus ultraviolet radiation
Methoxsalen Sanofi-Synthelabo Brand
Methoxsalen with ultra-violet A theraphy
Methoxsalen [BAN:JAN]
Methoxsalen, 8-
Methoxsalen-Supplied by Selleck Chemicals
Methoxy-8-psoralen
Mex America Brand of Methoxsalen
Mex-America Brand of Methoxsalen
MLS000062633
MLS002303011
NCGC00016418-01
NCGC00016418-02
NCGC00016418-03
NCGC00016418-04
NCGC00016418-05
NCGC00016418-06
NCGC00016418-07
NCGC00016418-08
NCGC00016418-09
NCGC00016418-10
NCGC00016418-11
NCGC00016418-12
NCGC00060938-02
NCGC00060938-03
NCGC00060938-04
NCGC00060938-05
NCGC00060938-06
NCGC00178871-01
NCGC00178871-02
NCGC00178871-03
NCI-C55903
NCI60_004085
New-Meladinin
NINDS_000763
NSC 45923
NSC45923
O-methylxanthotoxol
Oprea1_166319
Oxoralen
Oxsoralen
Oxsoralen (TN)
Oxsoralen Lotion
Oxsoralen Ul tra
Oxsoralen Ultra
Oxsoralen-Ultra
Oxypsoralen
Prestwick0_000479
Prestwick1_000479
Prestwick2_000479
Prestwick3_000479
Prestwick_661
proralone-mop
psoralen-mop
Psoralon-MOP
Puvalen
Puvamet
S1952_Selleck
SAM002548974
Sanofi Synthelabo Brand of Methoxsalen
Sanofi-Synthelabo Brand of Methoxsalen
SDCCGMLS-0042377.P002
SMR000071170
SPBio_001004
SPBio_002557
SPECTRUM1500400
Spectrum2_001052
Spectrum3_000499
Spectrum4_000052
Spectrum5_001891
Spectrum_001023
ST041029
STK735539
STOCK1N-03091
Ultra Mop
Ultramop
Ultramop Lotion
UNII-U4VJ29L7BQ
Uvadex
WLN: T C566 DO LVOJ BO1
X0009
Xanthotoxin
Xanthotoxin, Metoxaleno, Dltasoralen, Methoxsalen
Xanthotoxine
xanthoxin
zanthotoxin
ZINC02548959
ATC-Codes:
Side-Effects:
Side-EffectFrequency
erythema0
myocardial ischemia0
hypopigmentation0
herpes simplex0
nausea0
hypotension0
infection0
leg cramps0
malaise0
insomnia0
arrhythmia0
urticaria0
rash0
folliculitis0
blistering0
nervousness0
miliaria0
edema0
dizziness0
pruritus0
headache0

Target

show target details
Uniprot ID:CP1A1_HUMAN
Synonyms:
CYPIA1
Cytochrome P450 1A1
P450 form 6
P450-C
P450-P1
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----

References:

12814958
Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the rat.. Kaoru Kobayashi; Kikuko Urashima; Noriaki Shimada; Kan Chiba (2003) Drug metabolism and disposition: the biological fate of chemicals display abstract
The aim of this study was to determine the selectivities of chemical inhibitors for human cytochrome P450 (P450) isoforms toward the corresponding rat P450 isoforms by using cDNA-expressed rat P450s (CYP1A2, CYP2A1, CYP2C6, CYP2C11, CYP2D2, CYP2E1, CYP3A1, and CYP3A2). Among the inhibitor probes for human P450s used in this study, only sulfaphenazole showed a selective inhibitory effect on the activity of the corresponding rat P450 isoform (CYP2C6). Furafylline also preferentially inhibited the activity of rat CYP1A2. However, methoxalen and ketoconazole more strongly inhibited the activities of other P450 isoforms than those of the corresponding rat P450 isoforms, CYP2A1 and CYP3A1/2, respectively. On the other hand, quinidine and aniline had little effect on the activities of the corresponding rat P450 isoforms, CYP2D2, and rat CYP2E1, respectively. These results suggest that chemical probes that have been used for human P450 isoforms do not always exhibit the same selectivity for the corresponding rat P450 isoforms. However, it appears that sulfaphenazole can be used as a selective inhibitor for rat CYP2C6. In addition, furafylline may also be a relatively selective inhibitor for rat CYP1A2.
8474022