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Drug-Target Interaction

Drug

show drug details
PubChem ID:4112
Structure:
Synonyms:
(+)-Amethopterin
(+/-)Amethopterin hydrate
4-Amino-10-methylfolic acid
51865-79-3
59-05-2
6-Mtx (DL)
60388-53-6
82334-40-5
A7019_SIGMA
Amethopterin
Amethopterin (R,S)
BPBio1_000232
BPBio1_000579
BSPBio_000210
BSPBio_000525
BSPBio_001993
C19H23N9O4
CL 14377
D-Amethopterin
DL-4-Amino-N10-methylpteroylglutamic acid
DL-Amethopterin
DL-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-
DL-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
DL-Methotrexate
EINECS 262-213-7
EMT 25,299
Glutamic acid,
Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, DL-
Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl] methylamino]benzoyl]-, L-(+)-
HDMTX
L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
L-Glutamic acid, N-[4-[[2,4-diamino-6-pteridinyl)methyl]- methylamino]benzoyl]-
LS-71811
Metatrexan
Methopterin
METHOTREXATE
Methotrexate polyglutamate
Methotrexate, (DL)-Isomer
Methylaminopterin
MTX
N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-DL-glutamic acid
N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-DL-glutamic acid
NCGC00095284-01
NCGC00095284-02
NCI-C04671
NCI60_041622
NSC 117356
NSC117356
NSC740
Poly(imino((1S)-1-carboxy-4-oxo-1,4-butanediyl)), alpha-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-omega-hydroxy-
Poly(imino(1-carboxy-4-oxo-1,4-butanediyl)), alpha-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-omega-hydroxy-, (S)-
Prestwick0_000373
Prestwick1_000373
Prestwick2_000373
Prestwick3_000135
Prestwick3_000373
Prestwick_753
R 9985
SPBio_002446
SPECTRUM1500398
ST057254
TCMDC-123832
WLN: T66 BN DN GN JNJ CZ EZ H1N1&R DVMYVQ2VQ
Side-Effects:
Side-EffectFrequency
vasculitis0
dermatitis0
sweating0
convulsions0
furunculosis0
petechiae0
pancytopenia0
ecchymosis0
thrombophlebitis0
anorexia0
elevated liver enzymes0
pericardial effusion0
somnolence0
infection0
dementia0
gynecomastia0
exfoliative dermatitis0
pericarditis0
rash0
weakness0
aphasia0
folliculitis0
hematuria0
osteoporosis0
ulcerative stomatitis0
stomatitis0
fetal death0
ulcer0
enteritis0
cirrhosis0
pulmonary fibrosis0
conjunctivitis0
agranulocytosis0
dysarthria0
erythema multiforme0
sepsis0
cryptococcosis0
vomiting0
eosinophilia0
telangiectasia0
myalgia0
hypogammaglobulinemia0
arthralgia0
upper respiratory tract infection0
spinal cord disease0
hypotension0
melena0
headache0
mood alteration0
irritability0
cmv infection0
dyspnea0
acute renal failure0
toxic epidermal necrolysis0
respiratory failure0
constitutional symptoms0
pancreatitis0
proteinuria0
epistaxis0
thrombocytopenia0
hepatitis0
hemorrhage0
osteonecrosis0
neutropenia0
radiculopathy0
renal failure0
chest pain0
cognitive dysfunction0
lymphadenopathy0
decreased libido0
nausea0
bilirubinemia0
pneumocystis carinii pneumonia0
alopecia0
photosensitivity0
nephropathy0
interstitial pneumonitis0
speech disturbance0
pleural effusion0
deep vein thrombosis0
cerebral thrombosis0
infertility0
leukopenia0
cerebrovascular accident0
pain0
hepatic failure0
back pain0
fever0
acne0
hematemesis0
azotemia0
impotence0
confusion0
stevens - johnson syndrome0
blindness0
hyperuricemia0
pruritus0
urticaria0
anemia0
aplastic anemia0
vaginal discharge0
gingivitis0
pneumonia0
encephalopathy0
pulmonary edema0
fibrosis0
elevated liver function tests0
herpes zoster0
histoplasmosis0
anaphylaxis0
ureteral obstruction0
coma0
hemiparesis0
allergic alveolitis0
lung disorder0
glossitis0
neck rigidity0
cystitis0
seizures0
pulmonary embolism0
blurred vision0
chills0
aseptic meningitis0
cough0
hypersensitivity0
skin ulcer0
dizziness0
ataxia0
retinal vein thrombosis0
pharyngitis0
fatigue0
diarrhea0
tinnitus0
diabetes mellitus0
dysuria0
malaise0

Target

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Uniprot ID:TYSY_LACCA
Synonyms:
Thymidylate synthase
TS
TSase
EC-Numbers:2.1.1.45
Organism:Lactobacillus casei
PDB IDs:1BO7 1BO8 1BP0 1BP6 1BPJ 1JMF 1JMG 1JMH 1JMI 1LCA 1LCB 1LCE 1NJA 1NJB 1NJC 1NJD 1NJE 1TDA 1TDB 1TDC 1THY 1TSL 1TSM 1TSV 1TSW 1TSX 1TSY 1TSZ 1TVU 1TVV 1TVW 1VZA 1VZB 1VZC 1VZD 1VZE 2G86 2G89 2G8A 2G8D 2TDD 2TDM 3BNZ 3BYX 3BZ0 3C06 3C0A 4TMS
Structure:
4TMS

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--120000-

References: