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Drug-Target Interaction

Drug

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PubChem ID:3965
Structure:
Synonyms:
(+)-p-((2-oxocyclopentyl)methyl)hydratropic acid
(+-)-p-((2-Oxocyclopentyl)methyl)hydratropic acid
156-S
2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic acid
2-OCPPP
2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoic acid
68767-14-6
AC-15776
AC1L1H42
alpha-Methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid
C15H18O3
CCG-204763
CHEBI:122873
CHEMBL19299
CS 600
CS-600
D08149
EU-0100677
HMS3262G15
Koloxo
L 0664
L0664_SIGMA
Lopac0_000677
Loxoprofen
Loxoprofen (INN)
Loxoprofen [INN]
Loxoprofene
Loxoprofene [French]
Loxoprofeno
Loxoprofeno [Spanish]
Loxoprofenum
Loxoprofenum [Latin]
LS-176693
MolPort-005-933-136
NCGC00015594-02
NCGC00015594-03
NCGC00015594-04
NCGC00094037-01
NCGC00094037-02
SBB067214
sodium 2-(4-(2-oxocyclopentylmethyl)phenyl)propionate dihydrate
sodium loxoprofen
UNII-3583H0GZAP

Target

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Uniprot ID:Q6LCE7_HUMAN
Synonyms:
Cyclooxygenase-1
EC-Numbers:1.14.99.1
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11251697
Direct superoxide scavenging activity of nonsteroidal anti-inflammatory drugs: determination by electron spin resonance using the spin trap method.. Y Ikeda; K Matsumoto; K Dohi; H Jimbo; K Sasaki; K Satoh (2001) Headache display abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs), which are used widely to manage pain, are known to inhibit cyclooxygenase, but details of the mechanisms of NSAID action remain unclear. We investigated the ability of three NSAIDs (indomethacin, loxoprofen, and etodolac) to eliminate and inhibit free radicals. Superoxide scavenging activity of these NSAIDs was measured in vitro by electron spin resonance spectrometry using 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) as a spin trap. Electron spin resonance demonstrated that formation of superoxide-DMPO spin adduct was completely inhibited by two nonselective cyclooxygenase inhibitors, indomethacin (3 mmol) and loxoprofen (3 mmol). The electron spin resonance study also demonstrated that the formation of superoxide-DMPO spin adduct was strongly inhibited by a selective cyclooxygenase-2 inhibitor, etodolac, in a concentration-dependent manner. These results indicate that NSAIDs, including indomethacin, loxoprofen, and etodolac, have direct superoxide scavenging activity.