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Drug-Target Interaction

Drug

show drug details
PubChem ID:3883
Structure:
Synonyms:
103577-45-3
1H-Benzimidazole,
1H-Benzimidazole, 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-
2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole
2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)-1H-benzimidazole
2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole
2-({[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole
2-[({3-methyl-4-[(2,2,2-trifluoroethyl)oxy]pyridin-2-yl}methyl)sulfinyl]-1H-benzimidazole
2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole
2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl] methyl] sulfinyl] benzimidazole
2-[[[3-methyl-4-(2,2,2-trifluroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole
A 65006
A-65006
AB00052388
Abbot Brand of Lansoprazole
ABT-006
AG 1749
AG-1749
Agopton
Almirall Brand of Lansoprazole
Amarin
Aprazol
Bamalite
BB_SC-4646
Blason
BPBio1_001194
BRN 4333393
BSPBio_001084
BSPBio_001830
C058687
C16H14F3N3O2S
CAS-103577-45-3
CG-4801
CHEBI:6375
Compraz
CPD000058469
D00355
Dakar
DB00448
dexlansoprazole
DivK1c_000920
EU-0100709
Hoechst Brand of Lansoprazole
Hormona Brand of Lansoprazole
HSDB 7204
IDI1_000920
Ilsatec
KBio1_000920
KBio2_002060
KBio2_004628
KBio2_007196
KBio3_001330
KBioGR_001491
KBioSS_002060
Ketian
L8533_SIGMA
Lancid
Lanproton
Lansopep
Lansoprazol
Lansoprazol [INN-Spanish]
LANSOPRAZOLE
Lansoprazole (JAN/USP/INN)
lansoprazole sulphone
Lansoprazole [USAN:BAN:INN]
Lansoprazolum
Lansoprazolum [INN-Latin]
Lansox
Lanston
Lanz
Lanzo
Lanzol-30
Lanzopral
lanzoprazole
Lanzor
Lasoprol
Lederle Brand of Lansoprazole
Limpidex
Lopac-L-8533
Lopac0_000709
LS-33080
Mesactol
MLS-0003247.0001
MLS000069705
MLS000759405
MLS001074170
Monolitum
NCGC00015615-01
NCGC00015615-02
NCGC00015615-03
NCGC00023826-03
NCGC00023826-04
NCGC00023826-05
NCGC00023826-06
NCGC00023826-07
NINDS_000920
Ogast
Ogastro
Opiren
Prestwick0_001072
Prestwick1_001072
Prestwick2_001072
Prestwick3_001072
Prevacid
Prevacid (TN)
Prevacid I.V
Prevacid Iv
Prevacid SoluTab
PREVPAC
Prezal
Pro Ulco
Promeco
Promeco Brand of Lansoprazole
Promp
Prosogan
Salvar Brand of Lansoprazole
SAM001246544
SMR000058469
SPBio_000488
SPBio_002992
SPECTRUM1503926
Spectrum2_000444
Spectrum3_000295
Spectrum4_000856
Spectrum5_001521
Spectrum_001580
Suprecid
TAK 390MR
TAK-390MR
TAK390MR
Takeda Brand of Lansoprazole
Takepron
TAP Brand of Lansoprazole
Tecnobio Brand of Lansoprazole
TL8000155
Ulpax
Vinas Brand of Lansoprazole
Wyeth Brand of Lansoprazole
Zoprol
Zoton
ATC-Codes:
Side-Effects:
Side-EffectFrequency
abdominal pain0.016117645
diarrhea0.014527774
nausea0.008115385
constipation0.0056363638
thrombotic thrombocytopenic purpura0.0010
purpura0.0010
psychosis0.0010
pruritus0.0010
polyuria0.0010
normal laboratory0.0010
polyps0.0010
pneumonia0.0010
pharyngitis0.0010
retinal degeneration0.0010
rhinitis0.0010
visual field defect0.0010
sweating0.0010
cerebrovascular accident0.0010
stridor0.0010
ulcerative stomatitis0.0010
stomatitis0.0010
stevens - johnson syndrome0.0010
sinusitis0.0010
increased salivation0.0010
circulatory failure0.0010
convulsion0.0010
pelvic pain0.0010
paresthesia0.0010
nail disorder0.0010
myositis0.0010
myocardial infarction0.0010
musculoskeletal pain0.0010
menstrual disorder0.0010
menorrhagia0.0010
breast pain0.0010
leukopenia0.0010
leg cramps0.0010
laryngeal neoplasia0.0010
pancytopenia0.0010
interstitial nephritis0.0010
melena0.0010
pancreatitis0.0010
palpitations0.0010
pain0.0010
otitis media0.0010
optic neuritis0.0010
nightmares0.0010
neutropenia0.0010
neurosis0.0010
nervousness0.0010
kidney calculus0.0010
syncope0.0010
allergic reaction0.0010
dry eyes0.0010
rectal hemorrhage0.0010
fecal occult blood0.0010
breast tenderness0.0010
tenesmus0.0010
myalgia0.0010
malaise0.0010
esophageal ulcer0.0010
dry skin0.0010
eye pain0.0010
blurred vision0.0010
bradycardia0.0010
hearing loss0.0010
pseudomembranous colitis0.0010
insomnia0.0010
sleep disorder0.0010
acne0.0010
skin carcinoma0.0010
urinary frequency0.0010
kidney pain0.0010
lymphadenopathy0.0010
neuropathy0.0010
abnormal liver function tests0.0010
neck rigidity0.0010
abnormal vision0.0010
vertigo0.0010
ventricular tachycardia0.0010
vaginitis0.0010
urticaria0.0010
urinary tract infection0.0010
tremor0.0010
tinnitus0.0010
thrombocytopenia0.0010
tachycardia0.0010
vomiting0.0010
weight gain0.0010
migraine0.0010
mouth ulceration0.0010
peripheral edema0.0010
photophobia0.0010
agitation0.0010
urinary urgency0.0010
hepatic failure0.0010
chills0.0010
urinary retention0.0010
dry mouth0.0010
synovitis0.0010
eosinophilia0.0010
libido decreased0.0010
deafness0.0010
cough0.0010
convulsions0.0010
conjunctivitis0.0010
confusion0.0010
ulcerative colitis0.0010
colitis0.0010
cholelithiasis0.0010
dehydration0.0010
contact dermatitis0.0010
diabetes mellitus0.0010
enteritis0.0010
edema0.0010
dysuria0.0010
dyspnea0.0010
dyspepsia0.0010
dysmenorrhea0.0010
somnolence0.0010
dizziness0.0010
diplopia0.0010
chest pain0.0010
neck pain0.0010
cerebral infarction0.0010
anorexia0.0010
angina0.0010
hemolytic anemia0.0010
aplastic anemia0.0010
anemia0.0010
anaphylaxis0.0010
amnesia0.0010
amblyopia0.0010
alopecia0.0010
agranulocytosis0.0010
anxiety0.0010
arrhythmia0.0010
carcinoma0.0010
oral moniliasis0.0010
candidiasis0.0010
bronchitis0.0010
back pain0.0010
asthma0.0010
asthenia0.0010
arthritis0.0010
arthralgia0.0010
albuminuria0.0010
joint disorder0.0010
hiccup0.0010
hepatitis0.0010
hemoptysis0.0010
hemiplegia0.0010
hematuria0.0010
hematemesis0.0010
headache0.0010
hay fever0.0010
hallucinations0.0010
halitosis0.0010
bilirubinemia0.0010
hyperglycemia0.0010
hyperlipemia0.0010
jaundice0.0010
flu syndrome0.0010
infection0.0010
impotence0.0010
hypothyroidism0.0010
hypotension0.0010
hypoglycemia0.0010
breast enlargement0.0010
hypertension0.0010
hypersensitivity0.0010
hair disorder0.0010
gynecomastia0.0010
dysphagia0.0010
fever0.0010
flatulence0.0010
gastroenteritis0.0010
gastritis0.0010
esophagitis0.0010
esophageal stenosis0.0010
erythema multiforme0.0010
gastrointestinal hemorrhage0.0010
eructation0.0010
toxic epidermal necrolysis0.0010
epistaxis0.0010
gout0.0010
rash0.0010
goiter0.0010
glycosuria0.0010
glossitis0.0010
gum hemorrhage0.0010
manic0
duodenitis0
emotional lability0
apathy0
fatigue0
hiatal hernia0
depersonalization0
hoarseness0
hot flashes0
tooth disorder0
laboratory test abnormal0

Target

show target details
Uniprot ID:CP1A2_HUMAN
Synonyms:
CYPIA2
Cytochrome P450 1A2
P(3)450
P450 4
P450-P3
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:2HI4
Structure:
2HI4

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----
----

References:

12612455
Different contribution of CYP2C19 in the in vitro metabolism of three proton pump inhibitors.. Tomoko Kita; Toshiyuki Sakaeda; Takahiko Baba; Nobuo Aoyama; Mikio Kakumoto; Yoshie Kurimoto; Yuko Kawahara; Noboru Okamura; Shirou Kirita; Masato Kasuga; Katsuhiko Okumura (2003) Biological & pharmaceutical bulletin display abstract
A series of clinical studies on the cytochrome P450 2C19 (CYP2C19) genotype and the pharmacokinetics and pharmacodynamics of three proton pump inhibitors (PPIs), omeprazole, lansoprazole and rabeprazole, have been conducted to establish the individualized pharmacotherapy based on the CYP2C19 genotyping, and in the present study, the CYP2C19 genotype-dependency was more pronounced for omeprazole than the other two. Herein, to validate further the difference among 3 PPIs in CYP2C19 genotype-dependency on the phenotype, a comparative in vitro study was conducted using the human liver microsomes and newly developed anti-human CYP antibodies. The residual concentrations of omeprazole and lansoprazole in 5 lots of human liver microsomes were dependent on the CYP2C19 activities, however, for rabeprazole, there was no correlation. The hydroxylation of omeprazole was more inhibited by anti-CYP2C19 antibody than lansoprazole, whereas anti-CYP3A4 antibody showed similar inhibition. In conclusion, the relative contribution of CYP2C19 on total metabolism of 3 PPIs elucidated herein coincided with the CYP2C19 genotype-dependent pharmacokinetics.
12623754
8169844