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Drug-Target Interaction

Drug

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PubChem ID:3878
Structure:
Synonyms:
1,2,4-Triazine-3,5-diamine, 6-(2,3-dichlorophenyl)-
3,5-diamino-6-(2,3-dichlorophenyl)- as -triazine
3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine
6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diyldiamine
84057-84-1
AC-10298
AC1L1GWT
BIDD:GT0794
Bio-0056
BW 430C
BW-430C
C047781
C9H7Cl2N5
CCG-100856
CHEBI:138727
CHEBI:6367
CHEMBL741
CPD000058464
Crisomet
D00354
DB00555
Desitin Brand of Lamotrigine
EINECS 281-901-8
EU-0100688
EUR-1048
Faes Brand of Lamotrigine
GI 267119X
Glaxo Wellcome Brand of Lamotrigine
GlaxoSmithKline Brand of Lamotrigine
GW 273293
HMS2051C10
HMS2089M08
HMS2093P21
HMS2230L04
HMS3262I17
HSDB 7526
Juste Brand of Lamotrigine
L 3791
L3791_SIGMA
Labileno
Lamictal
Lamictal (TN)
LAMICTAL CD
Lamictal ODT
Lamictal XR
Lamictin
Lamiktal
Lamitor
Lamotrigina
Lamotrigina [Spanish]
LAMOTRIGINE
Lamotrigine (JAN/USAN/INN)
Lamotrigine [USAN:BAN:INN]
Lamotrigine [USAN:INN:BAN]
Lamotriginum
Lamotriginum [Latin]
Lopac-L-3791
Lopac0_000688
LS-155249
MLS000069685
MLS000759486
MLS001077325
NCGC00015605-01
NCGC00015605-02
NCGC00015605-03
NCGC00015605-04
NCGC00015605-05
NCGC00015605-06
NCGC00015605-07
NCGC00015605-08
NCGC00022936-02
NCGC00022936-04
NCGC00022936-05
NSC746307
SAM001246697
SMP2_000303
SMR000058464
STK628377
STOCK6S-49251
Tocris-1611
UNII-U3H27498KS
ZINC00013156
ATC-Codes:
Side-Effects:
Side-EffectFrequency
confusion1.0
amblyopia1.0
paresthesia1.0
headache0.25666663
dizziness0.20175001
diplopia0.14935483
nausea0.14
somnolence0.12750001
ataxia0.12519999
infection0.114999995
vomiting0.10133332
fever0.09999999
blurred vision0.093225785
pharyngitis0.0911111
rhinitis0.08142858
rash0.08009999
diarrhea0.07833333
back pain0.07333333
fatigue0.06999999
flu syndrome0.06666666
asthenia0.06666666
bronchitis0.06333333
insomnia0.062857136
abdominal pain0.061249986
cough0.061111107
tremor0.058000006
dry mouth0.053333335
dysmenorrhea0.05
dyspepsia0.04142857
weight decrease0.040000003
chest pain0.040000003
constipation0.03833333
anxiety0.035000004
pain0.035
gait abnormality0.03333333
vaginitis0.030000001
tooth disorder0.022000002
pruritus0.022000002
seizure0.020000001
urinary tract infection0.02
vision abnormal0.02
anorexia0.016666668
hemorrhage0.016666666
eczema0.016666666
sinusitis0.016666666
convulsions0.016666666
amenorrhea0.016666666
bronchospasm0.016666666
vertigo0.016666666
neck pain0.016666666
nervousness0.016666666
lymphadenopathy0.016666664
photosensitivity0.013333332
arthralgia0.013333332
edema0.013
phobia0.01
liver function tests abnormal0.01
tinnitus0.01
leukopenia0.01
impotence0.01
postural hypotension0.01
hypertension0.01
hot flashes0.01
hirsutism0.01
acne0.01
hematuria0.01
sleep disorder0.01
hallucinations0.01
breast pain0.01
menorrhagia0.01
allergic reaction0.01
psychosis0.01
tachycardia0.01
urinary incontinence0.01
urticaria0.01
polyuria0.01
chills0.01
personality disorder0.01
photophobia0.01
palpitations0.01
panic attack0.01
mouth ulceration0.01
malaise0.01
dry eyes0.01
movement disorder0.01
increased salivation0.01
halitosis0.01
ecchymosis0.01
ear pain0.01
flushing0.01
libido decreased0.01
gastritis0.01
aphasia0.01
eructation0.01
dyskinesia0.01
dysarthria0.01
dysphagia0.01
arthritis0.01
leg cramps0.01
conjunctivitis0.01
alopecia0.01
gingivitis0.01
faintness0.0054999995
deafness0.0010
uveitis0.0010
vasculitis0.0010
cystitis0.0010
contracture0.0010
thrombocytopenia0.0010
visual field defect0.0010
seborrhea0.0010
muscle spasm0.0010
stevens - johnson syndrome0.0010
stomach ulcer0.0010
stomatitis0.0010
strabismus0.0010
cerebrovascular accident0.0010
suicide attempt0.0010
delirium0.0010
vaginal moniliasis0.0010
bursitis0.0010
manic depression0.0010
red cell aplasia0.0010
angina pectoris0.0010
macrocytic anemia0.0010
hemolytic anemia0.0010
aplastic anemia0.0010
anemia0.0010
paralysis0.0010
kidney pain0.0010
agranulocytosis0.0010
abscess0.0010
parkinson0.0010
angioedema0.0010
leukoderma0.0010
atrial fibrillation0.0010
urinary retention0.0010
choreoathetosis0.0010
urinary urgency0.0010
erythema0.0010
apnea0.0010
breast abscess0.0010
goiter0.0010
deep thrombophlebitis0.0010
iron deficiency anemia0.0010
breast neoplasm0.0010
exfoliative dermatitis0.0010
hematemesis0.0010
joint disorder0.0010
lacrimation disorder0.0010
esophagitis0.0010
leukocytosis0.0010
acute kidney failure0.0010
lupus0.0010
lymphocytosis0.0010
melena0.0010
grand mal convulsions0.0010
epididymitis0.0010
muscle atrophy0.0010
hypothyroidism0.0010
pathological fracture0.0010
glossitis0.0010
hemiplegia0.0010
hepatitis0.0010
herpes zoster0.0010
hiccup0.0010
gum hemorrhage0.0010
gastrointestinal hemorrhage0.0010
bilirubinemia0.0010
hyperesthesia0.0010
hyperglycemia0.0010
hypersensitivity reaction0.0010
myocardial infarction0.0010
rhabdomyolysis0.0010
pancreatitis0.0010
pancytopenia0.0010
dysuria0.0010
colitis0.0010
petechia0.0010
ptosis0.0010
fungal dermatitis0.0010
kidney failure0.0010
neutropenia0.0010
neurosis0.0010
eosinophilia0.0010
nocturia0.0010
peripheral neuritis0.0010
neuralgia0.0010
contact dermatitis0
dyspnea0
epistaxis0
menstrual disorder0
weight gain0
peptic ulcer0
skin ulcer0
mood disorders0
delusions0
manic0
amnesia0
urinary frequency0
depersonalization0
dermatitis0
toxic epidermal necrolysis0
rectal hemorrhage0
drug withdrawal0
dysphoria0
scarring0
agitation0
apathy0
nystagmus0
apraxia0
peripheral edema0
asthma0
migraine0
stupor0
swelling0
dry skin0
irritability0
euphoria0
flatulence0
sweating0
myalgia0
emotional lability0

Target

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Uniprot ID:SCN4A_HUMAN
Synonyms:
SkM1
Sodium channel protein skeletal muscle subunit alpha
Sodium channel protein type 4 subunit alpha
Sodium channel protein type IV subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.4
EC-Numbers:-
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: