Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:3767
Structure:
Synonyms:
(HBD) Human beta-defensin-1 & INH
127942-30-7
37271-10-6
4-(Hydrazinocarbonyl)pyridine
4-pyridinecarbohydrazide
4-Pyridinecarbonylhydrazine
4-Pyridinecarboxylic acid hydrazide
4-Pyridinecarboxylic acid, hydrazide
4-Pyridinecarboxylic hydrazide
4-Pyridylcarbonylhydrazide
41466-07-3
5015 R.P
5015 R.P.
5015 RP
54-85-3
62229-51-0
7640-37-1
AB00052025
Abdizide
AC1L1GNZ
AC1Q54UP
AC1Q54UQ
AI3-23936
AIDS-007657
AIDS-032280
AIDS-088821
AIDS-211410
AIDS007657
AIDS032280
AIDS088821
AIDS211410
AKOS000119062
Amidon
Andrazide
Anidrasona
Antimicina
Antituberkulosum
Armacide
Armazid
Armazide
Atcotibine
AZT + Isoniazid
Azuren
bacillen
Bacillin
BB_SC-6246
BIDD:GT0140
Biomol-NT_000288
bp 5 015
Bp 5015
BPBio1_000025
BPBio1_001322
BSPBio_000021
BSPBio_002204
C07054
c1161
C6H7N3O
CAS-54-85-3
CCG-39710
CCRIS 351
Cedin
Cedin (Aerosol)
Cemidon
CHEBI:6030
CHEMBL64
Chemiazid
Chemidon
component of Niadox
Continazine
Cortinazine
Cotinazin
Cotinizin
CPD000059082
D00346
D007538
DB00951
Defonin
Dibutin
Diforin
Dinacrin
Ditubin
DivK1c_000070
DOW-ISONIAZID
DRG-0123
Ebidene
EINECS 200-214-6
Eralon
Ertuban
Eutizon
Evalon
Fetefu
Fimalene
FRS-3
FSR 3
FSR-3
Ftivazide
GINK
HIA
Hid rasonil
Hidranizil
Hidrasonil
Hidrulta
Hidrun
HMS1568B03
HMS1920H09
HMS2089I16
HMS2091N19
HMS2095B03
HMS2234G04
HMS3259E19
HMS500D12
HSDB 1647
Hycozid
Hydra
Hydrazid
Hydrazide
Hydrazide, Isonicotinic Acid
Hyozid
Hyzyd
I.A.I
I.A.I.
I0138
I14-9731
I3377_FLUKA
I3377_SIGMA
IDI1_000070
Ido-tebin
Idrazide dell'acido isonicotinico
Idrazide dell'acido isonicotinico [Italian]
Idrazil
In-73
Inah
INH
Inh-Burgthal
INHd20
Inizid
Iscotin
Isidrina
Ismazide
Isobicina
Isocid
Isocidene
isoco tin
Isocotin
Isohydrazide
Isokin
Isolyn
Isonerit
Isonex
Isoniacid
Isoniazid
Isoniazid & CRL8131
Isoniazid & EEP
Isoniazid & Propolis
Isoniazid (JP15/USP/INN)
Isoniazid (JP16/USP/INN)
Isoniazid daily for 9 months
Isoniazid SA
Isoniazid [BAN:INN:JAN]
Isoniazid [INN:BAN:JAN]
Isoniazid-Supplied by Selleck Chemicals
Isoniazida
Isoniazida [INN-Spanish]
Isoniazide
Isoniazidum
Isoniazidum [INN-Latin]
Isonicazide
Isonicid
Isonico
Isonicotan
Isonicotil
isonicotinate hydrazide
Isonicotinhydrazid
Isonicotinic acid hydrazide
Isonicotinic hydrazide
Isonicotinohydrazide
Isonicotinoyl hydrazide
isonicotinoylhydrazide
Isonicotinoylhydrazine
Isonicotinsaeurehydrazid
Isonicotinsaeurehydrazid [German]
Isonicotinyl hydrazide
Isonicotinyl hydrazine
Isonicotinylhydrazine
Isonide
Isonidrin
Isonikazid
Isonilex
Isonin
Isonindon
Isonirit
Isoniton
Isonizida
Isonizide
Isopyrin
Isotamine
Isotebe
Isotebezid
Isotinyl
Isozid
isozid e
Isozide
Isozyd
ISZ
KBio1_000070
KBio2_001333
KBio2_003901
KBio2_006469
KBio3_001424
KBioGR_000423
KBioSS_001333
L 1945
Laniazid
Laniazid (TN)
Laniozid
Lanizid
LS-205
Mixture Name
MLS000069444
MLS001055327
Mybasan
NCGC00016244-01
NCGC00016244-02
NCGC00016244-03
NCGC00016244-04
NCGC00016244-05
NCGC00016244-06
NCGC00016244-07
NCGC00016244-08
NCGC00016244-09
NCGC00016244-10
NCGC00016244-11
NCGC00016244-12
NCGC00022648-03
NCGC00022648-04
NCGC00022648-05
NCGC00022648-06
NCGC00022648-07
nchembio884-comp3
Neo-Tizide
Neoteben
Neoxin
Neumandin
Nevin
Niadrin
Niazid
Nicazide
Nicetal
Nicizina
Niconyl
Nicotibina
Nicotibine
Nicotisan
Nicozide
Nidaton
nidra zid
Nidrazid
Nikozid
NINDS_000070
Niplen
Nitadon
Niteban
Nitebannsc 9659
NSC 9659
NSC9659
Nydrazid
Nyscozid
Oprea1_396155
Pelazid
Percin
Phthisen
Phthivazide
Preparation 6424
Prestwick0_000161
Prestwick1_000161
Prestwick2_000161
Prestwick3_000161
Prestwick_578
Pycazide
Pyreazid
Pyricidin
Pyridicin
pyridine-4-carbohydrazide
pyridine-4-carboxylic acid hydrazide
Pyrizidin
Raumanon
Razide
Retozide
Rifamate
Rifater
Rimicid
rimif on
Rimifon
Rimiphone
Rimitsid
Robiselin
Robisellin
Roxifen
RP 5015
RP-5015
RU-EF-Tb
RY-EF-Tb
S1937_Selleck
SAM002554904
Sanohidrazina
Sauterazid
Sauterzid
SBB004195
SMR000059082
SPBio_000094
SPBio_001942
SPECTRUM1500355
Spectrum2_000107
Spectrum3_000472
Spectrum4_000022
Spectrum5_000876
Spectrum_000853
ST078858
Stanozide
STK086288
TB-Phlogin
TB-Razide
TB-Vis
Tebecid
tebemid
Tebenic
Tebexin
Tebilon
Tebos
Teebaconin
Tekazin
Tibazide
Tibemid
Tibiazide
Tibinide
Tibison
Tibivis
Tibizide
Tibusan
Tisin
Tisiodrazida
Tizide
Tubazid
Tubazide
Tubeco
Tubecotubercid
tubercid
Tuberian
Tubicon
Tubilysin
Tubizid
Tubizid, Laniazid, Nydrazid, Isoniazid
Tubomel
Tyvid
Unicocyde
Unicozyde
UNII-V83O1VOZ8L
UPCMLD0ENAT5791176:001
Usaf cb-2
Vazadrine
Vederon
WLN: T6NJ DVMZ
Zidafimia
Zinadon
ZINC00001590
Zonazide
ATC-Codes:
Side-Effects:
Side-EffectFrequency
hypersensitivity0.120000005
exfoliative dermatitis0.120000005
pruritus0.120000005
lyell syndrome0.120000005
rash0.120000005
erythema0.120000005
urticaria0.120000005
vomiting0.09
nausea0.09
diarrhea0.09
pain0.07333333
phlebitis0.055
edema0.055
joint pain0.055
coughing0.045
angina0.045
hemoptysis0.045
palpitation0.045
pneumothorax0.045
chest pain0.045
paresthesia0.035
tinnitus0.035
vertigo0.035
insomnia0.035
sweating0.035
coma0.035
anxiety0.035
headache0.035
fever0.024999999
jaundice0.01
hepatitis0.01
metabolic acidosis0
malaise0
lupus0
aplastic anemia0
memory impairment0
vasculitis0
anorexia0
lymphadenopathy0
encephalopathy0
convulsions0
agranulocytosis0
hyperglycemia0
bilirubinemia0
neuritis0
optic neuritis0
weakness0
gynecomastia0
peripheral neuropathy0
fatigue0
eosinophilia0
psychosis0
thrombocytopenia0

Target

show target details
Uniprot ID:CP2CJ_HUMAN
Synonyms:
(R)-limonene 6-monooxygenase
(S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase
CYPIIC17
CYPIIC19
Cytochrome P450 2C19
Mephenytoin 4-hydroxylase
P450-11A
P450-254C
EC-Numbers:1.14.13.48
1.14.13.49
1.14.13.80
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----

References:

11158730
Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: potent inhibition of CYP2C19 and CYP3A.. Z Desta; N V Soukhova; D A Flockhart (2001) Antimicrobial agents and chemotherapy display abstract
Isoniazid (INH) remains the most safe and cost-effective drug for the treatment and prophylaxis of tuberculosis. The use of INH has increased over the past years, largely as a result of the coepidemic of human immunodeficiency virus infection. It is frequently given chronically to critically ill patients who are coprescribed multiple medications. The ability of INH to elevate the concentrations in plasma and/or toxicity of coadministered drugs, including those of narrow therapeutic range (e.g., phenytoin), has been documented in humans, but the mechanisms involved are not well understood. Using human liver microsomes (HLMs), we tested the inhibitory effect of INH on the activity of common drug-metabolizing human cytochrome P450 (CYP450) isoforms using isoform-specific substrate probe reactions. Incubation experiments were performed at a single concentration of each substrate probe at its K(m) value with a range of INH concentrations. CYP2C19 and CYP3A were inhibited potently by INH in a concentration-dependent manner. At 50 microM INH (approximately 6.86 microg/ml), the activities of these isoforms decreased by approximately 40%. INH did not show significant inhibition (
15528841