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Drug-Target Interaction

Drug

show drug details
PubChem ID:3749
Structure:
Synonyms:
1,3-Diazaspiro(4.4)non-1-en-4-one, 2-butyl-3-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-
138402-11-6
2-Butyl-3-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-1,3-diazaspiro(4.4)non-1-en-4-one
2-butyl-3-[ p -( o -1 H -tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4,4]non-1-en-4-one
2-butyl-3-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4.4]non-1-en-4-one
2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]
2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
2-n-butyl-3-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1,3-diazaspiro(4,4)non-1-en-4-one
Aprovel
AVALIDE
Avapro
Avapro (TN)
BMS 186295
BMS Brand of Irbesartan
BMS-186295
Bristol Myers Brand of Irbesartan
BSPBio_002687
C07469
C081309
C25H28N6O
CHEBI:5959
CPD000466306
D00523
DB01029
Irbesartan
Irbesartan (JAN/USAN/INN)
Irbesartan [USAN:INN]
Irbetan
Karvea
KBio2_002231
KBio2_004799
KBio2_007367
KBio3_001907
KBioGR_001603
KBioSS_002231
LS-60064
MLS000759408
MLS001424099
NCGC00095122-01
NCGC00095122-02
NCGC00095122-03
SAM001246548
Sanofi Winthrop Brand of Irbesartan
SMR000466306
SPBio_001889
SPECTRUM1504259
Spectrum2_001675
Spectrum3_000994
Spectrum4_001122
Spectrum5_001288
Spectrum_001751
SR 47436
SR-47436
STOCK6S-44551
TL8000875
ATC-Codes:
Side-Effects:
Side-EffectFrequency
rhabdomyolysis0.0010
essential hypertension0.0010
type 2 diabetes0.0010
syncope0.0010
dizziness0.0010
orthostatic hypotension0.0010
proteinuria0.0010
urticaria0.0010
hypertension0.0010
hyperkalemia0.0010
hepatitis0.0010
swelling0.0010
renal disease0.0010
elevated liver function tests0.0010
jaundice0.0010
anemia0.0010
renal failure0.0010
angioedema0.0010
muscle pain0.0010
myositis0.0010
asthenia0.0010
neutropenia0.0010
muscle weakness0.0010
lymphocytopenia0.0010
thrombocytopenia0.0010
sexual dysfunction0
pruritus0
pharyngitis0
paresthesia0
joint stiffness0
nervousness0
nausea0
numbness0
rhinitis0
ear infection0
photosensitivity0
respiratory arrest0
oral lesion0
peripheral edema0
chills0
conjunctivitis0
vomiting0
abnormal vision0
vertigo0
urinary tract infection0
erythema0
tremor0
tracheobronchitis0
tachycardia0
cerebrovascular accident0
wheezing0
myocardial infarction0
ecchymosis0
ear pain0
dyspnea0
dyspepsia0
somnolence0
diarrhea0
dermatitis0
cough0
constipation0
chest pain0
transient ischemic attack0
bursitis0
arthritis0
anxiety0
angina pectoris0
abdominal pain0
edema0
emotional disturbances0
epistaxis0
musculoskeletal pain0
muscle cramps0
headache0
influenza0
infection0
hypotension0
heartburn0
cardiac murmur0
heart failure0
gout0
gastroenteritis0
flushing0
flatulence0
fever0
fatigue0
rash0
abdominal distention0

Target

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Uniprot ID:CP2C9_HUMAN
Synonyms:
(R)-limonene 6-monooxygenase
(S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase
CYPIIC9
Cytochrome P450 2C9
P-450MP
P450 MP-4/MP-8
P450 PB-1
S-mephenytoin 4-hydroxylase
EC-Numbers:1.14.13.48
1.14.13.49
1.14.13.80
Organism:Homo sapiens
Human
PDB IDs:1OG2 1OG5 1R9O
Structure:
1R9O

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: