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Drug-Target Interaction

Drug

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PubChem ID:3741
Structure:
Synonyms:
1,3-Benzenedicarboxamide, N,N'-bis(2,3-dihydroxypropyl)-5-((hydroxyacetyl)(2-hydroxyethyl)amino)-2,4,6-triiodo-
87771-40-2
AB00513943
BPBio1_001051
BRN 7155654
BSPBio_000955
D01555
IOVERSOL
Ioversol (JAN/USP/INN)
Ioversol [USAN:BAN:INN]
Ioversol [USAN:INN:BAN]
Ioversolum [Latin]
LS-29726
MP-328
N,N -bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)-glycolamidol]-2,4,6-triiodoisophthalamide
N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2-hydroxyethyl)glycolamido)-2,4,6-triiodoisophthalamide
n,n'-bis(2,3-dihydroxypropyl)-5-[glycoloyl(2-hydroxyethyl)amino]-2,4,6-tri
NCGC00179364-01
Optiray
Optiray (TN)
Optiray 160
Optiray 240
Optiray 320
Optiray 350
Prestwick0_000878
Prestwick1_000878
Prestwick2_000878
Prestwick3_000878
SPBio_002876
ATC-Codes:
Side-Effects:
Side-EffectFrequency
paresthesia0
tachycardia0
thrombophlebitis0
tinnitus0
tremor0
loss of consciousness0
erythema0
urticaria0
vasovagal reaction0
venous thrombosis0
syncope0
spasm0
sneezing0
polyuria0
puncture0
proteinuria0
pruritus0
pulmonary edema0
purpura0
renal failure0
seizures0
shock0
ventricular fibrillation0
vertigo0
lightheadedness0
visual hallucinations0
hypoxia0
blurred vision0
shortness of breath0
bradycardia0
blindness0
paralysis0
dysphasia0
sinus arrest0
respiratory arrest0
renal colic0
vomiting0
wheezing0
dry mouth0
urinary retention0
chills0
agitation0
peripheral edema0
neck rigidity0
myocardial ischemia0
allergic reaction0
pain0
anaphylaxis0
choking0
coma0
confusion0
conjunctivitis0
convulsions0
cough0
diarrhea0
somnolence0
dyspnea0
chest pain0
cerebral infarction0
bundle branch block0
aneurysm0
angina pectoris0
angioedema0
anxiety0
aphasia0
apnea0
arrhythmia0
asthma0
bronchospasm0
ecchymosis0
edema0
hemorrhage0
hypersensitivity0
hypertension0
hypotension0
nephropathy0
myocardial infarction0
nasal congestion0
nausea0
neutropenia0
hemiplegia0
hemiparesis0
hematuria0
rash0
fever0
flushing0
hallucinations0
headache0
cardiac arrest0
heart block0
congestive heart failure0
hematoma0
nystagmus0

Target

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Uniprot ID:THRB_SALSA
Synonyms:
Thrombin
EC-Numbers:3.4.21.5
Organism:Atlantic salmon
Salmo salar
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

9716151
Effects of radiographic contrast agents on thrombin formation and activity.. W P Fay; A C Parker (1998) Thrombosis and haemostasis display abstract
Clinical trials suggest that the risk of thrombosis during coronary angioplasty is lower with ionic contrast agents than with nonionic contrast agents. However, the molecular mechanisms underlying this effect are unknown. This study examined the effects of contrast agents on thrombin formation and its interaction with substrates, inhibitors, and ligands to define potential mechanisms by which contrast agents affect thrombus formation. Two ionic agents, diatrizoate and ioxaglate, and one nonionic agent, ioversol, were studied. Ionic agents inhibited factor X activation by the tissue factor-factor VIIa complex more potently than ioversol (53 +/- 3.7, 43.0 +/- 1.9, and 26.5 +/- 2.4% inhibition by diatrizoate, ioxaglate, and ioversol, respectively, at concentrations of 5%). Ionic contrast agents were potent inhibitors of prothrombinase function, inhibiting thrombin formation by >75% at contrast concentrations of 0.6% (p