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Drug-Target Interaction

Drug

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PubChem ID:3741
Structure:
Synonyms:
1,3-Benzenedicarboxamide, N,N'-bis(2,3-dihydroxypropyl)-5-((hydroxyacetyl)(2-hydroxyethyl)amino)-2,4,6-triiodo-
87771-40-2
AB00513943
BPBio1_001051
BRN 7155654
BSPBio_000955
D01555
IOVERSOL
Ioversol (JAN/USP/INN)
Ioversol [USAN:BAN:INN]
Ioversol [USAN:INN:BAN]
Ioversolum [Latin]
LS-29726
MP-328
N,N -bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)-glycolamidol]-2,4,6-triiodoisophthalamide
N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2-hydroxyethyl)glycolamido)-2,4,6-triiodoisophthalamide
n,n'-bis(2,3-dihydroxypropyl)-5-[glycoloyl(2-hydroxyethyl)amino]-2,4,6-tri
NCGC00179364-01
Optiray
Optiray (TN)
Optiray 160
Optiray 240
Optiray 320
Optiray 350
Prestwick0_000878
Prestwick1_000878
Prestwick2_000878
Prestwick3_000878
SPBio_002876
ATC-Codes:
Side-Effects:
Side-EffectFrequency
paresthesia0
tachycardia0
thrombophlebitis0
tinnitus0
tremor0
loss of consciousness0
erythema0
urticaria0
vasovagal reaction0
venous thrombosis0
syncope0
spasm0
sneezing0
polyuria0
puncture0
proteinuria0
pruritus0
pulmonary edema0
purpura0
renal failure0
seizures0
shock0
ventricular fibrillation0
vertigo0
lightheadedness0
visual hallucinations0
hypoxia0
blurred vision0
shortness of breath0
bradycardia0
blindness0
paralysis0
dysphasia0
sinus arrest0
respiratory arrest0
renal colic0
vomiting0
wheezing0
dry mouth0
urinary retention0
chills0
agitation0
peripheral edema0
neck rigidity0
myocardial ischemia0
allergic reaction0
pain0
anaphylaxis0
choking0
coma0
confusion0
conjunctivitis0
convulsions0
cough0
diarrhea0
somnolence0
dyspnea0
chest pain0
cerebral infarction0
bundle branch block0
aneurysm0
angina pectoris0
angioedema0
anxiety0
aphasia0
apnea0
arrhythmia0
asthma0
bronchospasm0
ecchymosis0
edema0
hemorrhage0
hypersensitivity0
hypertension0
hypotension0
nephropathy0
myocardial infarction0
nasal congestion0
nausea0
neutropenia0
hemiplegia0
hemiparesis0
hematuria0
rash0
fever0
flushing0
hallucinations0
headache0
cardiac arrest0
heart block0
congestive heart failure0
hematoma0
nystagmus0

Target

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Uniprot ID:PLMN_HUMAN
Synonyms:
Plasminogen
EC-Numbers:3.4.21.7
Organism:Homo sapiens
Human
PDB IDs:1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2PK4 5HPG
Structure:
5HPG

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11981110
An analysis of mechanisms underlying the antifibrinolytic properties of radiographic contrast agents.. P M Farrehi; Y Zhu; W P Fay (2001) Journal of thrombosis and thrombolysis display abstract
BACKGROUND: Radiographic contrast agents inhibit fibrinolysis, although by poorly defined pathways. The purpose of this study was to define specific mechanisms by which contrast agents inhibit clot lysis. METHODS AND RESULTS: Diatrizoate (high osmolar ionic agent), ioxaglate (low osmolar ionic), and ioversol (nonionic) were studied in vitro. Diatrizoate inhibited clot lysis by 81.3+/-0.6% vs. control (p0.3). Inhibition of fibrinolysis was not explained by the high osmolarities of contrast agents, by their iodine content, or by their effects on the amidolytic activities of t-PA, urokinase, or plasmin. However, plasminogen activation by t-PA, urokinase, or streptokinase was significantly inhibited by contrast agents. Diatrizoate, ioxaglate, and ioversol inhibited plasminogen binding to plasma clots by 51+/-4% (p