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Drug-Target Interaction

Drug

show drug details
PubChem ID:3715
Structure:
Synonyms:
(1-p-Chlorobenzoyl-5-methoxy-2-methylindol-3-yl)acetic acid
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid & MAP-30
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid
1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-essigsaeure
1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-essigsaeure [German]
1-(p-Chlorobenzoyl)-2-methoxy-3-methyl-1H-indole-3-acetic Acid
1-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indoleacetic acid
1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
1-p-Cloro-benzoil-5-metoxi-2-metilindol-3-acido acetico
1-p-Cloro-benzoil-5-metoxi-2-metilindol-3-acido acetico [Spanish]
1-[p-Chlorobenzoyl]-5-methoxy-2-methylindole-3-acetic acid
1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl- (9CI)
1z9h
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
37242-43-6
5-22-05-00239 (Beilstein Handbook Reference)
503560-73-4
53-86-1
74252-25-8
74252-25-8 (hydrochloride salt, tri-hydrate)
7681-54-1
7681-54-1 (hydrochloride salt)
91853-74-6
AB00052022
AC-532
AC1L1GJQ
Aconip
Aconip (TN)
AIDS-025351
AIDS-028381
AIDS025351
AIDS028381
AKOS000592893
alpha-(1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl)acetic acid
Amuno
Apo-Indomethacin
Argun
Arthrexin
Artracin
Artrinovo
Artrivia
BIDD:GT0132
BIM-0050670.0001
Bio-0704
Bio2_000405
Bio2_000885
Bonidin
Bonidon
Bonidon Gel
BPBio1_000160
BRD-K57222227-001-06-1
BRN 0497341
BSPBio_000144
BSPBio_001149
BSPBio_002176
C01926
C19H16ClNO4
CAS-53-86-1
Catlep
CCG-40186
CCRIS 3502
CGIGDMFJXJATDK-UHFFFAOYSA-
CHEBI:49662
CHEMBL6
Chibro-Amuno
Chrono-indicid
Chrono-indocid
Confortid
CPD-10545
D00141
DB00328
DESMETHYL INDOMETHACIN
DivK1c_000271
Dolcidium
Dolcidium PL
Dolovin
Durametacin
EINECS 200-186-5
Elmetacin
EU-0100692
Flexin continus
Hicin
HMS1362I11
HMS1568H06
HMS1792I11
HMS1920F21
HMS1990I11
HMS2089N19
HMS2091N09
HMS2095H06
HMS2231J10
HMS3262K05
HMS500N13
HSDB 3101
I 7378
I0655
I7378_SIGMA
I8280_SIGMA
IDI1_000271
IDI1_002160
Idomethine
Imbrilon
IMN
IN1454
Inacid
Indacin
Indameth
Indmethacine
INDO-LEMMON
Indo-Phlogont
Indo-rectolmin
Indo-Spray
Indo-tablinen
Indocid
Indocid (pharmaceutical)
Indocid Pda
Indocid Sr
Indocin
Indocin (TN)
Indocin I.V
Indocin I.V.
INDOCIN SR
Indolar SR
Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-
Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl- (8CI)
Indomecol
Indomed
Indomee
Indomet 140
Indometacin
Indometacin (JP15/INN)
Indometacin (JP16/INN)
Indometacina
Indometacina [INN-Spanish]
Indometacine
Indometacine [INN-French]
Indometacinum
Indometacinum [INN-Latin]
Indometacyna
Indometacyna [Polish]
Indomethacin
Indomethacin & MAP-30
Indomethacin (USP)
Indomethacin [USAN:BAN]
Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
Indomethacin-Supplied by Selleck Chemicals
Indomethacine
Indomethacinum
Indomethancin
Indomethazine
INDOMETHEGAN
Indomethine
Indometicina
Indometicina [Spanish]
Indomo
Indomod
Indoptic
Indoptol
Indorektal
Indoxen
Inflazon
Infrocin
Inteban SP
KBio1_000271
KBio2_000489
KBio2_001399
KBio2_003057
KBio2_003967
KBio2_005625
KBio2_006535
KBio3_000897
KBio3_000898
KBio3_001396
KBioGR_000395
KBioGR_000489
KBioSS_000489
KBioSS_001399
Kwas 1-(p-chlorobenzoilo)-2-metylo-5-metoksy-3-indolilooctowy
Kwas 1-(p-chlorobenzoilo)-2-metylo-5-metoksy-3-indolilooctowy [Polish]
L000959
Lausit
Liometacen
Lopac-I-7378
Lopac0_000692
LS-187
LS-82147
Metacen
Metartril
Methazine
Metindol
Mezlin
Mezlocillin
Mezolin
Miametan
Mikametan
MLS000069402
MLS000758212
MLS001074194
Mobilan
MolMap_000032
N-p-Chlorbenzoyl-5-methoxy-2-methylindole-3-acetic acid
NCGC00015562-01
NCGC00015562-02
NCGC00015562-03
NCGC00015562-04
NCGC00015562-05
NCGC00015562-06
NCGC00015562-07
NCGC00015562-08
NCGC00015562-09
NCGC00015562-10
NCGC00015562-11
NCGC00015562-12
NCGC00015562-13
NCGC00015562-14
NCGC00015562-15
NCGC00015562-16
NCGC00015562-17
NCGC00015562-18
NCGC00015562-19
NCGC00015562-20
NCGC00015562-21
NCGC00015562-22
NCGC00024135-02
NCGC00024135-04
NCGC00024135-05
NCGC00024135-06
NCGC00024135-07
NCGC00024135-08
NCGC00024135-09
NCGC00024135-10
NCGC00024135-11
NCGC00024135-12
NCGC00024135-13
NCGC00024135-14
NCGC00024135-15
nchembio.147-comp11
NCI-C56144
NCI60_041708
NINDS_000271
Novo-Methacin
Novomethacin
Nu-Indo
Oprea1_686105
Osmosin
Prestwick0_000272
Prestwick1_000272
Prestwick2_000272
Prestwick3_000272
Prestwick_597
Reumacide
Rhemacin LA
Rheumacin LA
S00108
S1723_Selleck
Sadoreum
SMR000058195
SMR000449290
SPBio_000979
SPBio_002363
SPECTRUM1500350
Spectrum2_000970
Spectrum3_000468
Spectrum4_000018
Spectrum5_000868
Spectrum_000919
ST5320042
Tannex
Tocris-1708
UNII-XXE1CET956
UPCMLD-DP023
UPCMLD-DP023:001
USAN
Vonum
[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
ATC-Codes:
Side-Effects:
Side-EffectFrequency
fasciitis0.0010
leukemia0.00075
thrombophlebitis0.00075
urinary frequency0.00075
purpura0.0
palpitations0.0
paresthesia0.0
peptic ulcer0.0
peripheral neuropathy0.0
petechiae0.0
proctitis0.0
retrolental fibroplasia0.0
pruritus0.0
renal failure0.0
pulmonary edema0.0
proteinuria0.0
hypertension0.0
pulmonary hypertension0.0
hypoglycemia0.0
hyponatremia0.0
fall in blood pressure0.0
infection0.0
jaundice0.0
pain0.0
leukopenia0.0
nausea0.0
interstitial nephritis0.0
nephrotic syndrome0.0
nervousness0.0
osteoarthritis0.0
shock0.0
ankylosing spondylitis0.0
stevens - johnson syndrome0.0
intestinal ulceration0.0
lightheadedness0.0
malaise0.0
epigastric pain0.0
parkinsonism0.0
rectal bleeding0.0
electrolyte imbalance0.0
blurred vision0.0
bradycardia0.0
preterm infant0.0
insomnia0.0
bloating0.0
muscle weakness0.0
vaginal bleeding0.0
intracranial bleeding0.0
ulcerative stomatitis0.0
sweating0.0
syncope0.0
tachycardia0.0
tinnitus0.0
ulcer0.0
uremia0.0
urticaria0.0
angiitis0.0
vertigo0.0
vomiting0.0
weight gain0.0
renal insufficiency0.0
hypersensitivity0.0
abdominal distention0.0
asthma0.0
carcinoma0.0
chest pain0.0
ulcerative colitis0.0
coma0.0
mental confusion0.0
constipation0.0
convulsions0.0
deafness0.0
exfoliative dermatitis0.0
diarrhea0.0
diplopia0.0
dizziness0.0
rheumatoid arthritis0.0
gouty arthritis0.0
acidosis0.0
agranulocytosis0.0
alkalosis0.0
loss of hair0.0
anaphylaxis0.0
anemia0.0
aplastic anemia0.0
hemolytic anemia0.0
angioedema0.0
anorexia0.0
anxiety0.0
apnea0.0
arrhythmia0.0
somnolence0.0
patent ductus arteriosus0.0
rash0.0
fatigue0.0
flatulence0.0
flushing0.0
gastroenteritis0.0
gastrointestinal bleeding0.0
glycosuria0.0
gynecomastia0.0
headache0.0
congestive heart failure0.0
heartburn0.0
hematuria0.0
hemorrhage0.0
hyperglycemia0.0
erythema nodosum0.0
hyperkalemia0.0
dysarthria0.0
indigestion0.0
dyspnea0.0
ecchymosis0.0
edema0.0
enterocolitis0.0
toxic epidermal necrolysis0.0
epistaxis0.0
epilepsy0.0
erythema multiforme0.0
seizures0
stomatitis0
apathy0
muzziness0
erythema0
depersonalization0
fever0
pneumothorax0
tenesmus0
clotting0

Target

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Uniprot ID:Q99MH2_MOUSE
Synonyms:
Cyclooxygenase 2
EC-Numbers:-
Organism:Mouse
Mus musculus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11876748
Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells.. N Kvirkvelia; I Vojnovic; T D Warner; V Athie-Morales; P Free; N Rayment; B M Chain; T W Rademacher; T Lund; I M Roitt; P J Delves (2002) Clinical and experimental immunology display abstract
A number of immunomodulatory molecules are present in the placenta, including cytokines, prostaglandins, progesterone and indoleamine 2,3-dioxygenase. An undefined factor capable of down-regulating T-cell activity has recently been reported [1] as being produced by short-term cultures of placental fragments. By careful repetition of these studies we have confirmed that chorionic villi isolated from term placenta produce a low molecular weight, heat stable factor capable of inhibiting the IL-2-dependent proliferation of mouse CTLL-2 cells. This activity was not due, however, to a previously unknown immunosuppressive molecule, but rather to prostaglandin E2 (PGE2). Expression of cyclooxygenase (COX)-2 was detected in the syncytiotrophoblast of chorionic villi explants using immunohistochemistry. Culture of the explants in the presence of the COX-1/COX--2 inhibitors indomethacin and diclofenac, or with the COX-2-selective inhibitor DFP, blocked the production of the immunosuppressive factor. The immunosuppressive activity was restored by adding PGE2 to the supernatants obtained from diclofenac-inhibited explants. A number of different receptors are involved in mediating the biological effects of prostaglandins. By utilizing selective antagonists of individual receptors, we have established that the immunosuppressive effect of PGE2 on CTLL-2 cells is exerted via the EP4 receptor. Thus, addition of an EP4-selective antagonist, but not of EP1 or EP3 antagonists, abolished the immunosuppressive effect of PGE2 on CTLL-2 cells. This may have implications for attempts to selectively manipulate T-cell responses.