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Drug-Target Interaction

Drug

show drug details
PubChem ID:3715
Structure:
Synonyms:
(1-p-Chlorobenzoyl-5-methoxy-2-methylindol-3-yl)acetic acid
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid & MAP-30
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid
1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-essigsaeure
1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-essigsaeure [German]
1-(p-Chlorobenzoyl)-2-methoxy-3-methyl-1H-indole-3-acetic Acid
1-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indoleacetic acid
1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
1-p-Cloro-benzoil-5-metoxi-2-metilindol-3-acido acetico
1-p-Cloro-benzoil-5-metoxi-2-metilindol-3-acido acetico [Spanish]
1-[p-Chlorobenzoyl]-5-methoxy-2-methylindole-3-acetic acid
1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl- (9CI)
1z9h
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
37242-43-6
5-22-05-00239 (Beilstein Handbook Reference)
503560-73-4
53-86-1
74252-25-8
74252-25-8 (hydrochloride salt, tri-hydrate)
7681-54-1
7681-54-1 (hydrochloride salt)
91853-74-6
AB00052022
AC-532
AC1L1GJQ
Aconip
Aconip (TN)
AIDS-025351
AIDS-028381
AIDS025351
AIDS028381
AKOS000592893
alpha-(1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl)acetic acid
Amuno
Apo-Indomethacin
Argun
Arthrexin
Artracin
Artrinovo
Artrivia
BIDD:GT0132
BIM-0050670.0001
Bio-0704
Bio2_000405
Bio2_000885
Bonidin
Bonidon
Bonidon Gel
BPBio1_000160
BRD-K57222227-001-06-1
BRN 0497341
BSPBio_000144
BSPBio_001149
BSPBio_002176
C01926
C19H16ClNO4
CAS-53-86-1
Catlep
CCG-40186
CCRIS 3502
CGIGDMFJXJATDK-UHFFFAOYSA-
CHEBI:49662
CHEMBL6
Chibro-Amuno
Chrono-indicid
Chrono-indocid
Confortid
CPD-10545
D00141
DB00328
DESMETHYL INDOMETHACIN
DivK1c_000271
Dolcidium
Dolcidium PL
Dolovin
Durametacin
EINECS 200-186-5
Elmetacin
EU-0100692
Flexin continus
Hicin
HMS1362I11
HMS1568H06
HMS1792I11
HMS1920F21
HMS1990I11
HMS2089N19
HMS2091N09
HMS2095H06
HMS2231J10
HMS3262K05
HMS500N13
HSDB 3101
I 7378
I0655
I7378_SIGMA
I8280_SIGMA
IDI1_000271
IDI1_002160
Idomethine
Imbrilon
IMN
IN1454
Inacid
Indacin
Indameth
Indmethacine
INDO-LEMMON
Indo-Phlogont
Indo-rectolmin
Indo-Spray
Indo-tablinen
Indocid
Indocid (pharmaceutical)
Indocid Pda
Indocid Sr
Indocin
Indocin (TN)
Indocin I.V
Indocin I.V.
INDOCIN SR
Indolar SR
Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-
Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl- (8CI)
Indomecol
Indomed
Indomee
Indomet 140
Indometacin
Indometacin (JP15/INN)
Indometacin (JP16/INN)
Indometacina
Indometacina [INN-Spanish]
Indometacine
Indometacine [INN-French]
Indometacinum
Indometacinum [INN-Latin]
Indometacyna
Indometacyna [Polish]
Indomethacin
Indomethacin & MAP-30
Indomethacin (USP)
Indomethacin [USAN:BAN]
Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
Indomethacin-Supplied by Selleck Chemicals
Indomethacine
Indomethacinum
Indomethancin
Indomethazine
INDOMETHEGAN
Indomethine
Indometicina
Indometicina [Spanish]
Indomo
Indomod
Indoptic
Indoptol
Indorektal
Indoxen
Inflazon
Infrocin
Inteban SP
KBio1_000271
KBio2_000489
KBio2_001399
KBio2_003057
KBio2_003967
KBio2_005625
KBio2_006535
KBio3_000897
KBio3_000898
KBio3_001396
KBioGR_000395
KBioGR_000489
KBioSS_000489
KBioSS_001399
Kwas 1-(p-chlorobenzoilo)-2-metylo-5-metoksy-3-indolilooctowy
Kwas 1-(p-chlorobenzoilo)-2-metylo-5-metoksy-3-indolilooctowy [Polish]
L000959
Lausit
Liometacen
Lopac-I-7378
Lopac0_000692
LS-187
LS-82147
Metacen
Metartril
Methazine
Metindol
Mezlin
Mezlocillin
Mezolin
Miametan
Mikametan
MLS000069402
MLS000758212
MLS001074194
Mobilan
MolMap_000032
N-p-Chlorbenzoyl-5-methoxy-2-methylindole-3-acetic acid
NCGC00015562-01
NCGC00015562-02
NCGC00015562-03
NCGC00015562-04
NCGC00015562-05
NCGC00015562-06
NCGC00015562-07
NCGC00015562-08
NCGC00015562-09
NCGC00015562-10
NCGC00015562-11
NCGC00015562-12
NCGC00015562-13
NCGC00015562-14
NCGC00015562-15
NCGC00015562-16
NCGC00015562-17
NCGC00015562-18
NCGC00015562-19
NCGC00015562-20
NCGC00015562-21
NCGC00015562-22
NCGC00024135-02
NCGC00024135-04
NCGC00024135-05
NCGC00024135-06
NCGC00024135-07
NCGC00024135-08
NCGC00024135-09
NCGC00024135-10
NCGC00024135-11
NCGC00024135-12
NCGC00024135-13
NCGC00024135-14
NCGC00024135-15
nchembio.147-comp11
NCI-C56144
NCI60_041708
NINDS_000271
Novo-Methacin
Novomethacin
Nu-Indo
Oprea1_686105
Osmosin
Prestwick0_000272
Prestwick1_000272
Prestwick2_000272
Prestwick3_000272
Prestwick_597
Reumacide
Rhemacin LA
Rheumacin LA
S00108
S1723_Selleck
Sadoreum
SMR000058195
SMR000449290
SPBio_000979
SPBio_002363
SPECTRUM1500350
Spectrum2_000970
Spectrum3_000468
Spectrum4_000018
Spectrum5_000868
Spectrum_000919
ST5320042
Tannex
Tocris-1708
UNII-XXE1CET956
UPCMLD-DP023
UPCMLD-DP023:001
USAN
Vonum
[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
ATC-Codes:
Side-Effects:
Side-EffectFrequency
fasciitis0.0010
leukemia0.00075
thrombophlebitis0.00075
urinary frequency0.00075
purpura0.0
palpitations0.0
paresthesia0.0
peptic ulcer0.0
peripheral neuropathy0.0
petechiae0.0
proctitis0.0
retrolental fibroplasia0.0
pruritus0.0
renal failure0.0
pulmonary edema0.0
proteinuria0.0
hypertension0.0
pulmonary hypertension0.0
hypoglycemia0.0
hyponatremia0.0
fall in blood pressure0.0
infection0.0
jaundice0.0
pain0.0
leukopenia0.0
nausea0.0
interstitial nephritis0.0
nephrotic syndrome0.0
nervousness0.0
osteoarthritis0.0
shock0.0
ankylosing spondylitis0.0
stevens - johnson syndrome0.0
intestinal ulceration0.0
lightheadedness0.0
malaise0.0
epigastric pain0.0
parkinsonism0.0
rectal bleeding0.0
electrolyte imbalance0.0
blurred vision0.0
bradycardia0.0
preterm infant0.0
insomnia0.0
bloating0.0
muscle weakness0.0
vaginal bleeding0.0
intracranial bleeding0.0
ulcerative stomatitis0.0
sweating0.0
syncope0.0
tachycardia0.0
tinnitus0.0
ulcer0.0
uremia0.0
urticaria0.0
angiitis0.0
vertigo0.0
vomiting0.0
weight gain0.0
renal insufficiency0.0
hypersensitivity0.0
abdominal distention0.0
asthma0.0
carcinoma0.0
chest pain0.0
ulcerative colitis0.0
coma0.0
mental confusion0.0
constipation0.0
convulsions0.0
deafness0.0
exfoliative dermatitis0.0
diarrhea0.0
diplopia0.0
dizziness0.0
rheumatoid arthritis0.0
gouty arthritis0.0
acidosis0.0
agranulocytosis0.0
alkalosis0.0
loss of hair0.0
anaphylaxis0.0
anemia0.0
aplastic anemia0.0
hemolytic anemia0.0
angioedema0.0
anorexia0.0
anxiety0.0
apnea0.0
arrhythmia0.0
somnolence0.0
patent ductus arteriosus0.0
rash0.0
fatigue0.0
flatulence0.0
flushing0.0
gastroenteritis0.0
gastrointestinal bleeding0.0
glycosuria0.0
gynecomastia0.0
headache0.0
congestive heart failure0.0
heartburn0.0
hematuria0.0
hemorrhage0.0
hyperglycemia0.0
erythema nodosum0.0
hyperkalemia0.0
dysarthria0.0
indigestion0.0
dyspnea0.0
ecchymosis0.0
edema0.0
enterocolitis0.0
toxic epidermal necrolysis0.0
epistaxis0.0
epilepsy0.0
erythema multiforme0.0
seizures0
stomatitis0
apathy0
muzziness0
erythema0
depersonalization0
fever0
pneumothorax0
tenesmus0
clotting0

Target

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Uniprot ID:ALDR_HUMAN
Synonyms:
Aldehyde reductase
Aldose reductase
AR
EC-Numbers:1.1.1.21
Organism:Homo sapiens
Human
PDB IDs:1ABN 1ADS 1AZ1 1AZ2 1EF3 1EL3 1IEI 1MAR 1PWL 1PWM 1T40 1T41 1US0 1X96 1X97 1X98 1XGD 1Z3N 1Z89 1Z8A 2ACQ 2ACR 2ACS 2ACU 2AGT 2DUX 2DUZ 2DV0 2F2K 2FZ8 2FZ9 2FZB 2FZD 2HV5 2HVN 2HVO 2I16 2I17 2IKG 2IKH 2IKI 2IKJ 2INE 2INZ 2IPW 2IQ0 2IQD 2IS7 2ISF 2J8T 2NVC 2NVD 2PD5 2PD9 2PDB 2PDC 2PDF 2PDG 2PDH 2PDI 2PDJ 2PDK 2PDL 2PDM 2PDN 2PDP 2PDQ 2PDU 2PDW 2PDX 2PDY 2PEV 2PF8 2PFH 2PZN 2QXW 2R24 3BCJ 3DN5 3G5E 3GHR 3GHS 3GHT 3GHU
Structure:
3GHU

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--6000.0-

References: