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Drug-Target Interaction

Drug

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PubChem ID:370
Structure:
Synonyms:
149-91-7
3,4,5-Trihydroxybenzoate
3,4,5-Trihydroxybenzoic acid
3-10-00-02070 (Beilstein Handbook Reference)
398225_SIAL
78563C7D-0E2D-4766-A8EA-670A03C78FCF
AB1002218
AC-1206
AC1L1934
AC1Q732X
AC1Q732Y
Acid, Gallic
AI3-16412
AIDS-001349
AIDS-059239
AIDS001349
AIDS059239
AKOS000119625
ARONIS23903
BB_SC-2795
Benzoic acid, 3,4,5-trihydroxy-
BIDD:ER0374
bmse000389
BRN 2050274
BSPBio_001668
C01424
CCG-38670
CCRIS 5523
CHEBI:30778
CHEMBL288114
CPD-183
D005707
DivK1c_006403
EINECS 205-749-9
G0011
G7384_SIGMA
Gallate
Gallic acid
GALLIC ACID ANHYDROUS
gallic acid for microelectronic industrial
Gallic Acid Hydrate
Gallic acid monohydrate
Gallic acid polymer
Gallic acid, tech
Gallic acid, tech.
GALOP
HMS1923K07
HMS2091A07
HSDB 2117
I14-9302
Jsp002851
KBio1_001347
KBio2_000822
KBio2_003390
KBio2_005958
KBio3_001168
KBioGR_002008
KBioSS_000822
Kyselina 3,4,5-trihydroxybenzoova
Kyselina 3,4,5-trihydroxybenzoova [Czech]
Kyselina gallova
Kyselina gallova [Czech]
LS-870
MolPort-000-881-260
NCGC00091125-01
NCGC00091125-02
NCGC00091125-03
NCGC00091125-04
NCGC00091125-05
nchembio.246-comp4
NSC 20103
NSC 674319
NSC20103
NSC674319
Oprea1_087792
Pyrogallol-5-carboxylic acid
SBB008781
SDCCGMLS-0066503.P001
SPBio_000617
SpecPlus_000307
SPECTRUM210369
Spectrum2_000399
Spectrum3_000254
Spectrum4_001544
Spectrum5_000108
Spectrum_000342
ST083487
STK298718
UNII-632XD903SP
WLN: QVR CQ DQ EQ

Target

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Uniprot ID:ICE_DROME
Synonyms:
Caspase
drICE
EC-Numbers:3.4.22.-
Organism:Drosophila melanogaster
Fruit fly
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

17685632
Gallic acid induces apoptosis in 3T3-L1 pre-adipocytes via a Fas- and mitochondrial-mediated pathway.. Chin-Lin Hsu; Wen-Hsieh Lo; Gow-Chin Yen (2007) Journal of agricultural and food chemistry display abstract
Gallic acid (3,4,5-trihydroxybenzoic acid) is a naturally abundant plant phenolic compound. Our previous studies have shown that some phenolic acids such as gallic acid inhibit cell growth and induce apoptosis in 3T3-L1 pre-adipocytes. However, the molecular mechanism of gallic acid in the induction of cell apoptosis is still unclear. In this study, we investigated the effect of gallic acid on the apoptotic pathway in 3T3-L1 pre-adipocytes. Western blot data revealed that gallic acid stimulated an increase in the protein expression of Fas, FasL, and p53. The ratio of expression levels of pro- and anti-apoptotic Bcl-2 family members was changed by gallic acid treatment. Gallic acid released mitochondrial cytochrome c into the cytosol and subsequently induced the activation of caspase-9 and caspase-3, which were followed by the cleavage of poly(ADP-ribose) polymerase. Pretreatment with a general caspase-9 inhibitor (Z-LEHD-FMK) and caspase-3 inhibitor (Z-DEVD-FMK) prevented gallic acid from inhibiting cell viability in 3T3-L1 pre-adipocytes. The data also indicated that treatment with gallic acid inhibited histone deacetylase activity in 3T3-L1 pre-adipocytes. These results demonstrate that gallic acid induces apoptosis in 3T3-L1 pre-adipocytes through the Fas and mitochondrial pathway. The induction of cell apoptosis by gallic acid may prove to be a pivotal mechanism for decreased pre-adipocyte proliferation.