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Drug-Target Interaction

Drug

show drug details
PubChem ID:3690
Structure:
Synonyms:
(+)-ifosfamid
(+)-ifosphamide
(+)-tetrahydro-n,3-bis(2-chloroethyl)-2h-1,3,2-oxazaphosphorin-2-amine 2-oxide
(+-)-Ifosfamid
(+-)-Ifosphamide
(+-)-Tetrahydro-N,3-bis(2-chloroethyl)-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
(D,L)-Ifosfamide
(R,S)-Ifosphamide
(R,S)-N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide
1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
2,3-(N,N(sup 1)-Bis(2-chloroethyl)diamido)-1,3,2-oxazaphosphoridinoxyd
2,3-N,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxy-
2,3-N,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxyd
2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis( 2-chloroethyl)tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-,
2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide
2h-1,3,2-oxazaphosphorin-2-amine, tetrahydro-n,3-bis(2-chloroethyl)-, 2-oxide, (+)-
2H-1,3,2-Oxazaphosphorin-2-amine, tetrahydro-N,3-bis(2-chloroethyl)-, 2-oxide, (+-)-
2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide (8CI)
2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
3-(2-Chloroethyl)-2-((2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine oxide
3-(2-Chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorine oxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorineoxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2- oxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
36341-88-5
3778-73-2
84711-20-6
A 4942
AB00513932
AIDS-126436
AIDS126436
ASTA Z 4942
BPBio1_000865
BRN 0611835
BSPBio_000785
C07047
C7H15Cl2N2O2P
CAS-3778-73-2
CCRIS 352
Cyfos
D00343
D007069
DB01181
DRG-0207
EINECS 223-237-3
Holoxan
Holoxan 1000
HSDB 7023
I-Phosphamide
Ifex
Ifex (TN)
IFEX/MESNEX KIT
Ifosamide
Ifosfamid
Ifosfamida
Ifosfamida [INN-Spanish]
Ifosfamide
Ifosfamide (JAN/USP/INN)
Ifosfamide Sterile
Ifosfamide [USAN:BAN:INN:JAN]
Ifosfamide [USAN:INN:BAN:JAN]
IFOSFAMIDE/MESNA KIT
Ifosfamidum
Ifosfamidum [INN-Latin]
Ifsofamide
Iphosphamid
Iphosphamid(e)
Iphosphamide
Iso Endoxan
Iso-Endoxan
Isoendoxan
Isofosfamide
Isophosphamide
LS-102
LS-99799
Mitoxana
MJF 9325
MJF-9325
MLS002154021
N,3-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,3-bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2$l^{5}-phosphacyclohexan-2-amine
N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
N,N-Bis(beta-chloroethyl)-amino-N',O-propylene-phosphoric acid ester diamide
N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid [German]
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylen ephosphoric acid diamide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid diamide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide
N-(2-Chloroethyl)-N-(3-(2-chloroethyl)-2-oxido-1,3,2-oxazaphosphinan-2-yl)amine
Naxamide
NCGC00016639-01
NCGC00179435-01
NCI-C01638
NCI60_000233
NSC 109,724
NSC 109724
NSC-109,724
NSC-109724
NSC109,724
NSC109724
Prestwick0_000833
Prestwick1_000833
Prestwick2_000833
Prestwick3_000833
SMR001233348
SPBio_002706
WLN: T6NPOTJ AM2G BO B2G
Z 4942
Z-4942
Z4942
{3-(2-Chloroethyl)-2-[(2-
{3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,} 2-oxazaphosphorine oxide
ATC-Codes:
Side-Effects:
Side-EffectFrequency
auditory hallucinations0
siadh0
nephrogenic diabetes insipidus0
pulmonary fibrosis0
dysuria0
pyrexia of unknown origin0
encephalopathy0
confusion0
seizures0
peripheral neuropathy0
vomiting0
renal tubular acidosis0
asthenia0
dermatitis0
hypotension0
nausea0
thrombophlebitis0
stupor0
allergic reaction0
leukopenia0
cystitis0
infection0
somnolence0
polyneuropathy0
depressive psychosis0
hallucinations0
interstitial pneumonitis0
blurred vision0
coma0
alopecia0
anorexia0
acidosis0
constitutional symptoms0
arrhythmia0
hypersensitivity0
hematemesis0
amenorrhea0
metabolic acidosis0
heart failure0
proteinuria0
hyperaminoaciduria0
pancreatitis0
fever0
hematuria0
hyperpigmentation0
agitation0
generalized seizures0
rickets0
thrombocytopenia0
nephropathy0
arteriosclerosis0
anemia0
renal tumor0
urinary frequency0
encephalitis0
renal failure0
constipation0
dizziness0
stomatitis0
pulmonary edema0
hypertension0
urinary incontinence0
neutropenia0
hemorrhage0
diarrhea0

Target

show target details
Uniprot ID:DNMT1_HUMAN
Synonyms:
CXXC-type zinc finger protein 9
DNA (cytosine-5)-methyltransferase 1
DNA methyltransferase HsaI
DNA MTase HsaI
Dnmt1
M.HsaI
MCMT
EC-Numbers:2.1.1.37
Organism:Homo sapiens
Human
PDB IDs:3EPZ
Structure:
3EPZ

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References: