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Drug-Target Interaction

Drug

show drug details
PubChem ID:3672
Structure:
Synonyms:
( -)-Ibuprofen
( inverted question mark)-Ibuprofen
(+)-2-(p-isobutylphenyl)propionic acid
(+)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid
(+)-ibuprofen
(+)-ibuprophen
(+)-p-isobutylhydratropic acid
(+-)-2-(p-Isobutylphenyl)propionic acid
(+-)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
(+-)-Ibuprofen
(+-)-Ibuprophen
(+-)-p-Isobutylhydratropic acid
(+/-)-2-(4-Isobutylphenyl)Propanoic Acid
(+/-)-Ibuprofen
(.+-.)-2-(p-Isobutylphenyl)propionic acid
(.+-.)-p-Isobutylhydratropic acid
(.+.)-2-(p-isobutylphenyl)propionic acid
(.+.)-p-isobutylhydratropic acid
(4-Isobutylphenyl)-alpha-methylacetic acid
(? inverted exclamation markA)-2-(4-Isobutylphenyl)Propanoic Acid
(?)-Ibuprofen
(RS)-Ibuprofen
(S)-4-Isobutyl-alpha-methylphenylacetic acid
.alpha.-(4-Isobutylphenyl)propionic acid
.alpha.-(p-isobutylphenyl)propionic acid
.alpha.-Methyl-4-(2-methylpropyl)benzeneacetic acid
139466-08-3
15687-27-1
2-(4-Isobutyl-phenyl)-propionic acid
2-(4-Isobutylphenyl)propanoic acid
2-(4-ISOBUTYLPHENYL)PROPIONIC ACID
2-(p-Isobutylphenyl)propionic acid
2-[4-(2-methylpropyl)phenyl]propanoic acid
31121-93-4
31121-93-4 (hydrochloride salt)
4-Isobutyl-.alpha.-methylphenylacetic acid
4-Isobutyl-alpha-methylphenylacetic acid
4-Isobutylhydratropic acid
58560-75-1
79261-49-7
79261-49-7 (potassium salt)
AC-11312
AC1L1GGE
AC1Q1P84
AC1Q1P85
ACHES-N-PAIN
Acide (isobutyl-4 phenyl)-2 propionique
Acide (isobutyl-4-phenyl)-2 propionique
Acide (isobutyl-4-phenyl)-2 propionique [French]
Act-3
Actiprofen
Adex 200
Adran
Advil
Advil (TN)
Advil Cold & Sinus
ADVIL COLD AND SINUS
Advil Liqui-Gels
Advil Migraine Liqui-Gels
Advil, Children's
AIDS-025464
AIDS025464
Ak+C2278tren
ak???
AKOS003237488
Alaxan
Algofen
alpha-(4-Isobutylphenyl)propionic acid
alpha-(p-isobutylphenyl)propionic acid
alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
alpha-Methyl-4-(isobutyl)phenylacetic acid
alpha-Methyl-4-[2-methylpropyl] benzeneacetic Acid
alpha-p-Isobutylphenylpropionic acid
Am-Fam 400
Amelior
Amersol
Amibufen
Anafen
Anco
Andran
Anflagen
Antagil
Antalfene
Antarene
Antiflam
Apo-Ibuprofen
Apsifen
Apsifen-F
ARONIS23835
Artofen
Artril
Artril 300
Balkaprofen
Bayer Select Pain Relief
BB_SC-1358
Benzeneacetic acid, .alpha.-methyl-4-(2-methylpropyl)-
Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl), (+-)-
Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-
Betaprofen
BIDD:GT0050
Bloom
Bluton
BRD-A17655518-001-02-0
BRN 2049713
Brofen
Brufanic
Brufen
Brufen 400
Brufen Retard
Bruflam
Brufort
BSPBio_002170
Buburone
Bufeno
Bufigen
Bukrefen
Bupron
Buracaps
Burana
Butacortelone
Butylenin
C01588
C13H18O2
CAP-PROFEN
Carol
CBMicro_005634
CCG-38947
CCRIS 3223
Cesra
CHEBI:5855
CHEMBL521
Children's Advil
CHILDREN'S ADVIL COLD
CHILDREN'S ADVIL-FLAVORED
Children's Elixsure
Children's Elixsure IB
CHILDREN'S IBUPROFEN
Children's Motrin
CHILDREN'S MOTRIN COLD
Citalgan
Cobo
Codral
Codral Period Pain
Combiflam
Combunox
CPD000058184
Cunil
D00126
Daiprophen
Dalsy
Dansida
DB01050
Deep Relief
Dentigoa
Dibufen
Dignoflex
DivK1c_000887
Dolgin
Dolgirid
Dolgit
Dolibu
Dolmaral
DOLO PUREN
Dolo-Dolgit
Dolocyl
Dolofen
Dolofen-F
Dolofin
Dolofort
Dologel
Dolomax
Doloren
Dolormin
Doltibil
Dolven
Donjust B
Dorival
DRG-0069
Drin
Dristan Sinus
Duafen
Dularbuprofen
Duobrus
Dura-Ibu
duralbuprofen
Dysdolen
Easifon
Ebufac
EINECS 239-784-6
Emflam
Emflam-200
Epobron
Eputex
Ergix
Esprenit
EU-0100691
Exneural
Faspic
Femadon
Femafen
Femapirin
Femidol
Fenbid
Fenbid Spansule
Fendol
Fenspan
Fibraflex
Gelufene
Genpril, Brufen, Nurofen, Motrin, Ibren, Ibuprohm, Ibuprofen
Gofen
Grefen
Gynofug
Haltran
HEFNNWSXXWATRW-UHFFFAOYSA-
Hemagene Tailleur
HMS1920F15
HMS2089P05
HMS2091N03
HMS2230N04
HMS3259G05
HMS3262K03
HMS502M09
HSDB 3099
Hydratropic acid, p-isobutyl-
I 4883
I01-7039
I0415
I4883_SIGMA
I7905_SIAL
IB-100
Ibol
Ibren
Ibu
Ibu-Attritin
Ibu-slo
Ibu-slow
Ibu-Tab
IBU-TAB 200
Ibubest
Ibubeta
Ibucasen
Ibudol
Ibudolor
Ibufen
Ibuflamar
Ibufug
Ibugel
Ibugen
Ibugesic
Ibuhexal
Ibulagic
Ibular
Ibulav
Ibuleve
Ibulgan
Ibumed
Ibumerck
Ibumetin
Ibupirac
Ibuprin
Ibuprocin
Ibuprofen
ibuprofen (+) mixture
Ibuprofen (+-) mixture
Ibuprofen (JP15/USP/INN)
Ibuprofen (JP16/USP/INN)
IBUPROFEN AND PSEUDOEPHEDRINE HCL
Ibuprofen I.V. Solution
Ibuprofen [USAN:BAN:INN:JAN]
Ibuprofen [USAN]
Ibuprofen-Supplied by Selleck Chemicals
Ibuprofen-Zinc
Ibuprofene
Ibuprofene [INN-French]
Ibuprofeno
Ibuprofeno [INN-Spanish]
Ibuprofenum
Ibuprofenum [INN-Latin]
Ibuprohm
IBUPROHM COLD AND SINUS
Ibuprophen
Ibusal
Ibutid
IDI1_000887
Ifen
Inabrin
Inflam
Inoven
IP-82
Ipren
Irfen
Isodol
Jenaprofen
Junifen
JUNIOR STRENGTH ADVIL
JUNIOR STRENGTH IBUPROFEN
JUNIOR STRENGTH MOTRIN
KBio1_000887
KBio2_001329
KBio2_003897
KBio2_006465
KBio3_001390
KBioGR_000389
KBioSS_001329
Kesan
Kontagripp Mono
Kratalgin
Lamidon
Lebrufen
Librofem
Lidifen
Liptan
Lopac0_000691
Lopane
LS-7454
Malafene
Manypren
Medipren
Melfen
Mensoton
MIDOL
Midol 200
Midol IB Cramp Relief
Mixture Name
MLS000069733
MLS001146965
Moment
Motrin
Motrin (TN)
Motrin IB
Motrin IB Gelcaps
MOTRIN MIGRAINE PAIN
Mynosedin
Nagifen-D
Napacetin
Narfen
NCGC00015529-04
NCGC00015529-05
NCGC00015529-06
NCGC00015529-07
NCGC00015529-08
NCGC00015529-09
NCGC00015529-10
NCGC00015529-12
NCGC00015529-13
NCGC00015529-14
NCGC00089819-02
NCGC00089819-03
NCGC00089819-04
NCGC00089819-05
NCGC00089819-06
NCGC00089819-07
nchembio.188-comp50
NCI60_002065
Neo-Helvagit
Neo-Mindol
Neobrufen
Neoprofen
Nerofen
NINDS_000887
Noalgil
Nobafon
Nobfelon
Nobfen
Nobgen
Noritis
Norton
Novadol
Novo Dioxadol
Novo-Profen
Novogent
Novogent N
Novoprofen
NSC 256857
NSC256857
Nuprilan
Nuprin
Nurofen
Optifen
Opturem
Oralfene
Ostarin
Ostofen
Ozonol
p-Isobutyl-2-phenylpropionic acid
p-Isobutylhydratropic acid
Paduden
Panafen
Pantrop
Para-Isobutylhydratropic Acid
Paxofen
Pedia-Profen
PediaProfen
PEDIATRIC ADVIL
Perofen
Proartinal
Profen
Proflex
Provon
Quadrax
R.D. 13621
Rafen
Ranofen
RD 13621
Rebugen
Relcofen
Rhinadvil
Rofen
Roidenin
Rufen
Rufin
Rupan
S1638_Selleck
Sadefen
Salivia
Salprofen
SAM002264619
Schmerz-Dolgit
Seclodin
Sednafen
Seklodin
Seskafen
SINE-AID IB
Sine-Aid IB Caplets
Siyafen
SMR000058184
Solpaflex
Solufen
SPBio_000178
SPECTRUM1500347
Spectrum2_000129
Spectrum3_000465
Spectrum4_000015
Spectrum5_000862
Spectrum_000849
ST024750
Stelar
STK177358
Sugafen
Suprafen
Suspren
Syntofene
TAB-PROFEN
Tabalon
Tabalon 400
Tatanal
Tempil
TL8001184
Tofen
Togal N
Tonal
Trauma-Dolgit Gel
Trendar
U 18573
U-18,573
U-18573
UCB 79171
UNII-WK2XYI10QM
Unipron
Upfen
Uprofen
Urem
VICOPROFEN
VUFB 9649
WLN: QVY&R DIY
Zafen
Zofen
[(+/-)-2-(4-Isobutylphenyl)-propionic Acid
ATC-Codes:
Side-Effects:
Side-EffectFrequency
infection0.19
skin lesion0.16
hypoglycemia0.12
hypocalcemia0.12
respiratory failure0.1
urinary tract infection0.09
adrenal insufficiency0.07
atelectasis0.04
apnea0.028900001
bleeding0.019407395
renal insufficiency0.0069000004
hypernatremia0.004833334
renal failure0.00325
edema0.0024444435
hematuria0.001375
menorrhagia0.0010
otitis media0.0010
dysfunctional uterine bleeding0.0010
nausea0.0010
nervousness0.0010
tumor0.0010
optic neuritis0.0010
meningoencephalitis0.0010
heartburn0.0010
hypertension0.0010
hypotension0.0010
jaundice0.0010
acute renal failure0.0010
renal papillary necrosis0.0010
leukopenia0.0010
melena0.0010
aseptic meningitis0.0010
pain0.0010
palpitations0.0010
paresthesias0.0010
urticaria0.0010
diminished vision0.0010
sinus bradycardia0.0010
abnormal liver function tests0.0010
tachycardia0.0010
metabolic acidosis0.0010
epigastric pain0.0010
azotemia0.0010
bradycardia0.0010
elevated blood pressure0.0010
bloating0.0010
erythema0.0010
tinnitus0.0010
pharyngitis0.0010
polyuria0.0010
pruritis0.0010
purpura0.0010
rhinitis0.0010
seizures0.0010
serum sickness0.0010
stevens - johnson syndrome0.0010
sinus tachycardia0.0010
thrombocytopenia0.0010
insomnia0.0010
congestive heart failure0.0010
atrial fibrillation0.0010
dizziness0.0010
drowsiness0.0010
anaphylaxis0.0010
convulsions0.0010
duodenal ulcer0.0010
amblyopia0.0010
alopecia0.0010
eosinophilia0.0010
anemia0.0010
diplopia0.0010
aplastic anemia0.0010
coma0.0010
confusion0.0010
conjunctivitis0.0010
connective tissue disease0.0010
constipation0.0010
arrhythmias0.0010
haemolytic anaemia0.0010
diarrhoea0.0010
epistaxis0.0010
granulocytopenia0.0010
fasciitis0.0010
flatulence0.0010
gastritis0.0010
acidosis0.0010
abdominal pain0.0010
gynecomastia0.0010
fever0.0010
abdominal cramps0.0010
hallucinations0.0010
headache0.0010
toxic epidermal necrolysis0.0010
rash0.0010
erythema multiforme0.0010
hepatitis0.001
indigestion0.001
lupus0.001
gastrointestinal hemorrhage0.001
emesis0.001
chills0
dry mouth0
hepatic necrosis0
angioedema0
photosensitivity0
vertigo0
vasculitis0
anxiety0
malaise0
blurred vision0
hearing loss0
abdominal distention0
lymphadenopathy0
sepsis0
elevated liver enzymes0
rectal hemorrhage0
cataract0
emotional lability0
dry eyes0
cognitive dysfunction0
hepatic failure0
asthenia0
dysuria0
interstitial nephritis0
ecchymosis0
enterocolitis0
myocardial infarction0
muscle cramps0
heart failure0
eructation0
esophagitis0
gastroesophageal reflux0
glossitis0
hyperglycemia0
inguinal hernia0
hepatorenal syndrome0
neutropenia0
dyspnea0
tremor0
asthma0
bronchospasm0
syncope0
cerebrovascular accident0
stomatitis0
pancreatitis0
cystitis0
exfoliative dermatitis0
pseudotumor cerebri0
proteinuria0
pneumonia0
pancytopenia0
duodenitis0
hematemesis0

Target

show target details
Uniprot ID:CP2CJ_HUMAN
Synonyms:
(R)-limonene 6-monooxygenase
(S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase
CYPIIC17
CYPIIC19
Cytochrome P450 2C19
Mephenytoin 4-hydroxylase
P450-11A
P450-254C
EC-Numbers:1.14.13.48
1.14.13.49
1.14.13.80
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----

References: