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Drug-Target Interaction

Drug

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PubChem ID:3562
Structure:
Synonyms:
(+-)-2-Bromo-2-chloro-1,1,1-trifluoroethane
(R)-2-Bromo-2-chloro-1,1,1-trifluoroethane
1,1,1-Trifluoro-2-bromo-2-chloroethane
1,1,1-Trifluoro-2-chloro-2-bromoethane
1-Bromo-1-chloro-2,2,2-trifluoroethane
151-67-7
16730_FLUKA
2,2,2-Trifluoro-1-chloro-1-bromoethane
2-Brom-2-chlor-1,1,1-trifluorethan
2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE
4-01-00-00156 (Beilstein Handbook Reference)
51230-17-2
AC1L1G7T
Alotano
Alotano [DCIT]
Anestan
B4388_SIGMA
BCQZXOMGPXTTIC-UHFFFAOYSA-
BRN 1736947
Bromchlortrifluoraethanum
Bromochlorotrifluoroethane
C07515
C2HBrClF3
CCRIS 6244
Cf3chclbr
Chalothane
CHEBI:5615
CHEMBL931
D00542
D006221
DB01159
DB02330
EINECS 205-796-5
Ethane, 1-bromo-1-chloro-2,2,2-trifluoro-
Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-
Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-, (+-)-
Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-, (R)-
Fluktan
Fluorotane
Fluorothane
Fluothane
Fluothane (TN)
Freon 123B1
Ftorotan
Ftorotan [Russian]
Ftuorotan
Halan
Halotan
Halotano
Halotano [INN-Spanish]
Halothan
Halothane
Halothane (JP15/USP/INN)
Halothane (JP16/USP/INN)
Halothane [Anaesthetics, volatile]
Halothane [BAN:INN:JAN]
Halothane [INN:BAN:JAN]
Halothanum
Halothanum [INN-Latin]
Halsan
HMS2094K17
HSDB 6753
LS-881
Narcotan
Narcotane
Narcotann ne-spofa
Narcotann NE-spofa [Russian]
Narkotan
NCGC00090868-01
NCGC00090868-02
NCGC00090868-03
NSC 143490
NSC143490
Phthorothanum
Rhodialothan
UNII-UQT9G45D1P
WLN: GYEXFFF
ATC-Codes:
Side-Effects:
Side-EffectFrequency
arrhythmia0
cardiac arrest0
hypotension0
nausea0
vomiting0
hepatic necrosis0
respiratory arrest0

Target

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Uniprot ID:NOS1_RAT
Synonyms:
BNOS
Constitutive NOS
N-NOS
NC-NOS
Neuronal NOS
Nitric oxide synthase, brain
nNOS
NOS type I
EC-Numbers:1.14.13.39
Organism:Rat
Rattus norvegicus
PDB IDs:1B8Q 1F20 1K2R 1K2S 1K2T 1K2U 1LZX 1LZZ 1M00 1MMV 1MMW 1OM4 1OM5 1P6H 1P6I 1P6J 1P6K 1QAU 1QAV 1QW6 1QWC 1RS6 1RS7 1TLL 1VAG 1ZVI 1ZVL 1ZZQ 1ZZR 1ZZU 2G6H 2G6I 2G6J 2G6K 2G6L 2G6M 2G6N 2HX3 2HX4 3B3M 3B3N 3B3O 3B3P 3DQR
Structure:
3DQR

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11506125
Halothane but not isoflurane attenuates interleukin 1beta-induced nitric oxide synthase in vascular smooth muscle.. H Maeda; H Iranami; M Yamamoto; K Ogawa; Y Morikawa; E Senba; Y Hatano (2001) Anesthesiology display abstract
BACKGROUND: Inducible nitric oxide synthase (iNOS) is induced by endotoxin or cytokines, such as interleukin (IL)-1, through a protein synthesis pathway. Halothane reportedly inhibits protein synthesis in various tissues. The aim of the current study was to examine the effect of halothane on the IL-1beta-evoked induction of NOS in vascular smooth muscle. METHODS: After removal of the endothelium, arterial rings of rat aorta were mounted in an isometric force recording system. The effects of halothane (1.0-3.0%) or isoflurane (3.0%) on IL-1beta (20 ng/ml)-induced inhibition of the contractile responses to KCl (30 mM) and phenylephrine (10(-9)-10(-5) M) were studied. The cyclic guanosine monophosphate and cyclic adenosine monophosphate contents were determined by radioimmunoassay. Expression of iNOS and iNOS mRNA were measured by Western or Northern blot analysis, respectively. RESULTS: Halothane (1.0-3.0%) but not isoflurane (3%) significantly reduced the ML-1beta-induced inhibition of contraction in a concentration-dependent manner. The cyclic guanosine monophosphate content of the vascular smooth muscle increased significantly after a 5-h exposure to IL-1beta. Halothane at 3.0% significantly inhibited the increase in cyclic guanosine monophosphate content induced by IL-1beta. Halothane had no effect on cyclic adenosine monophosphate content. IL-1beta-induced expression of iNOS and iNOS mRNA in the rat aorta were inhibited significantly by halothane. CONCLUSION: The current study demonstrated that halothane but not isoflurane inhibits IL-1beta-stimulated hyporesponsiveness to vasoconstrictive agents in vascular smooth muscle and that this inhibitory effect of halothane involves the inhibition of iNOS mRNA expression. Thus, these findings suggest that halothane may have some sites to affect nitric oxide-signaling pathway.