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Drug-Target Interaction

Drug

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PubChem ID:34698
Structure:
Synonyms:
(5R-(5alpha,5abeta,8aalpha,9beta(R*)))-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4-6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)oxy)furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one
23362-13-2
29767-20-2
31514-29-1
35317-44-3
4'-Demethyl
4'-Demethyl 1-O-(4,6-O,O-(2-thenylidene)-beta-D-glucopyranosyl)epipodophyllotoxin
4'-Demethyl-epipodophyllotoxin-beta-D-thenylidene-glucoside
4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-2-thenylidene-beta-D-glucopyranoside)
4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside)
4'-Demethylepipodophyllotoxin-beta-D-thenylidine glucoside
4'-Dimethyl-9-(4,6-O-2-thenyid)-epipodophyllotoxin
AC1L1S3X
CCRIS 2058
DB00444
EINECS 249-831-2
Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside)
Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) (8CI)
Epipodophyllotoxin-beta-D-thenylidene-glucoside, 4'-demethyl-
EPT
Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-((R)-2-thienylmethylene)-beta-D-glucopyranosyl)oxy)-, (5R,5aR,8aR,9S)-
HSDB 6546
NSC 122819
NSC-122819
TENIPOSIDE
Teniposide [USAN:BAN:INN]
Teniposido
Teniposido [INN-Spanish]
Teniposidum
Teniposidum [INN-Latin]
UNII-957E6438QA
Vee M-26
Veham-Sandoz
Vehem
VM-26
Vumon
ATC-Codes:
Side-Effects:
Side-EffectFrequency
abdominal pain0
hypotension0
infection0
leukemia0
aml0
leukopenia0
nausea0
tumor0
neutropenia0
pruritus0
stomatitis0
sweating0
tachycardia0
thrombocytopenia0
urticaria0
vomiting0
chills0
neuropathy0
hypertension0
hypersensitivity0
hemorrhage0
alopecia0
anemia0
hemolytic anemia0
anorexia0
arrhythmia0
asthenia0
brain tumor0
bronchospasm0
cancer0
confusion0
diarrhea0
dyspnea0
edema0
rash0
fever0
flushing0
headache0
allergic reaction0

Target

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Uniprot ID:TOP2A_HUMAN
Synonyms:
DNA topoisomerase 2-alpha
DNA topoisomerase II, alpha isozyme
EC-Numbers:5.99.1.3
Organism:Homo sapiens
Human
PDB IDs:1LWZ 1ZXM 1ZXN
Structure:
1ZXN

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: