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Drug-Target Interaction

Drug

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PubChem ID:3423265
Structure:
Synonyms:
05030_FLUKA
111726-87-5
121481-64-9
12738-53-3
12765-21-8
129203-37-8
1334-67-4
1335-72-4
145269-44-9
151-21-3
152155-52-7
156108-01-9
172826-72-1
191490-40-1
237743-45-2
303179-49-9
436143_SIAL
51222-39-0
57176-54-2
58640-35-0
61711-39-5
62862_RIEDEL
62862_SIAL
64441-33-4
71717_FLUKA
71717_SIGMA
71725_FLUKA
71725_SIGMA
71726_FLUKA
71729_FLUKA
71729_SIGMA
71736_FLUKA
71736_SIGMA
74433-77-5
8012-56-4
8048-56-4
952092-90-9
AC1MQ93Y
AG-D-98079
AI3-00356
Akyposal SDS
Anticerumen
Aquarex ME
Aquarex methyl
Avirol 101
Avirol 118 conc
Berol 452
C11166
Carsonol SLS
Carsonol SLS Paste B
Carsonol SLS Special
Caswell No. 779
CCRIS 6272
CHEBI:8984
CHEMBL23393
Conco sulfate WA
Conco sulfate WA-1200
Conco sulfate WA-1245
Conco Sulfate WAG
Conco Sulfate WAN
Conco Sulfate WAS
Conco sulfate WN
CP 75424
Cycloryl 21
Cycloryl 31
Cycloryl 580
Cycloryl 585N
D01045
DB00815
Dehydag sulfate GL emulsion
Dehydag sulphate GL emulsion
Dehydrag sulfate gl emulsion
Detergent 66
Dodecyl alcohol, hydrogen sulfate, sodium salt
Dodecyl sodium sulfate
Dodecyl sulfate sodium
Dodecyl sulfate sodium salt
Dodecyl sulfate, sodium salt
Dodecylsulfuric Acid Sodium Salt
Dreft
Dupanol WAQ
Duponal
Duponal WAQE
Duponol
Duponol C
Duponol ME
Duponol methyl
Duponol QC
Duponol QX
Duponol WA
Duponol WA Dry
Duponol WAQ
Duponol WAQA
Duponol WAQE
Duponol WAQM
EINECS 205-788-1
EMAL 10
EMAL O
Emersal 6400
Empicol LPZ
Empicol LS 30
Empicol LX 28
Emulsifier No. 104
EPA Pesticide Chemical Code 079011
Finasol osr(sub 2)
Finasol osr2
Gardinol
Hexamol SLS
HSDB 1315
I0352
I09-0526
Incronol SLS
IPC-SDS
Irium
Jordanol SL-300
L3771_SIGMA
L4390_SIGMA
L4509_SIAL
L4522_SIGMA
L5750_SIAL
L6026_SIAL
Lanette wax-S
Lauryl sodium sulfate
Lauryl sulfate sodium
Lauryl sulfate sodium salt
Lauryl sulfate, sodium salt
Laurylsiran sodny
Laurylsiran sodny [Czech]
Laurylsulfuric Acid Sodium Salt
Lauyl sodium sulfate
LS-880
Maprobix NEU
Maprofix 563
Maprofix LK
Maprofix NEU
Maprofix WAC
Maprofix wac-LA
Melanol CL
Melanol CL 30
Monagen Y 100
Monododecyl sodium sulfate
Monogen Y 100
Montopol LA paste
MP SILICA RP 18
n-Dodecyl sulfate sodium
NADDS
NALS
Natrium laurylsulfonicum
Natrium laurylsulfuricum
Natriumlaurylsulfat
NCGC00091020-01
NCGC00091020-02
NCGC00091020-03
NCI-C50191
Neutrazyme
Nikkol SLS
NSC 402488
Odoripon AL 95
Orvus WA paste
P and G emulsifier 104
Perklankrol ESD 60
Perlandrol L
Perlankrol L
Product No. 161
Product No. 75
Quolac EX-UB
Rewopol NLS 30
Richonol A
Richonol AF
Richonol C
S-4600
S0588
SBB060993
SDS
SDS Running Buffer
Sinnopon LS 100
Sinnopon LS 95
Sintapon L
Sipex OP
Sipex SB
Sipex SD
Sipex SP
Sipex UB
Sipon LS
Sipon LS 100
Sipon LSB
Sipon PD
Sipon WD
SLS
Sodium dedecyl sulfate
Sodium dodecyl sulfate
Sodium dodecyl sulfate solution
SODIUM DODECYL SULFATE, ULTRA PURE
Sodium Dodecyl Sulfonate
Sodium dodecyl sulphate
Sodium dodecylsulfate
Sodium lauryl sulfate
Sodium lauryl sulfate (JP15/NF)
Sodium lauryl sulfate (JP16/NF)
Sodium lauryl sulfate 30%
Sodium lauryl sulfate ether
Sodium lauryl sulfate solution
Sodium Lauryl Sulfate [USAN:JAN]
Sodium lauryl sulfate, dental grade
Sodium lauryl sulphate
Sodium monododecyl sulfate
Sodium monolauryl sulfate
Sodium n-dodecyl sulfate
Sodiumlauryl ether sulfate
Solsol needles
Standapol 112 conc
Standapol WA-AC
Standapol WAQ
Standapol WAQ Special
Standapol WAS 100
Steinapol NLS 90
Stepanol ME
Stepanol ME Dry
Stepanol ME Dry AW
Stepanol methyl
Stepanol methyl dry AW
Stepanol T 28
Stepanol WA
Stepanol WA paste
Stepanol WA-100
Stepanol WAC
Stepanol WAQ
Sterling WA paste
Sterling WAQ-CH
Sulfuric acid dodecyl ester sodium salt
Sulfuric acid monododecyl ester sodium salt
Sulfuric acid monododecyl ester sodium salt (1:1)
Sulfuric acid, monododecyl ester, sodium salt
UNII-368GB5141J

Target

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Uniprot ID:DUOX1_RAT
Synonyms:
Dual oxidase 1
EC-Numbers:1.11.1.-
1.6.3.1
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

12847113
AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase.. Jamie R Privratsky; Loren E Wold; James R Sowers; Mark T Quinn; Jun Ren (2003) Hypertension display abstract
Enhanced tissue angiotensin (Ang) II levels have been reported in diabetes and might lead to cardiac dysfunction through oxidative stress. This study examined the effect of blocking the Ang II type 1 (AT1) receptor on high glucose-induced cardiac contractile dysfunction. Rat ventricular myocytes were maintained in normal- (NG, 5.5 mmol/L) or high- (HG, 25.5 mmol/L) glucose medium for 24 hours. Mechanical and intracellular Ca2+ properties were assessed as peak shortening (PS), time to PS (TPS), time to 90% relengthening (TR90), maximal velocity of shortening/relengthening (+/-dL/dt), and intracellular Ca2+ decay (tau). HG myocytes exhibited normal PS; decreased +/-dL/dt; and prolonged TPS, TR90, and tau. Interestingly, the HG-induced abnormalities were prevented with the AT1 blocker L-158,809 (10 to 1000 nmol/L) but not the Janus kinase-2 (JAK2) inhibitor AG-490 (10 to 100 micromol/L). The only effect of AT1 blockade on NG myocytes was enhanced PS at 1000 nmol/L. AT1 antagonist-elicited cardiac protection against HG was nullified by the NADPH oxidase activator sodium dodecyl sulfate (80 micromol/L) and mimicked by the NADPH oxidase inhibitors diphenyleneiodonium (10 micromol/L) or apocynin (100 micromol/L). Western blot analysis confirmed that the protein abundance of NADPH oxidase subunit p47phox and the AT1 but not the AT2 receptor was enhanced in HG myocytes. In addition, the HG-induced increase of p47phox was prevented by L-158,809. Enhanced reactive oxygen species production observed in HG myocytes was prevented by AT1 blockade or NADPH oxidase inhibition. Collectively, our data suggest that local Ang II, acting via AT1 receptor-mediated NADPH oxidase activation, is involved in hyperglycemia-induced cardiomyocyte dysfunction, which might play a role in diabetic cardiomyopathy.