Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:3415
Structure:
Synonyms:
1nki
4428-95-9
4428-95-9 (FREE ACID)
63585-09-1
63585-09-1 (tri-hydrochloride salt)
63585-09-1(TRISODIUM SALT)
AC1L1FVT
AIDS-000052
AIDS-000754
AIDS-115928
AIDS-225806
AIDS000052
AIDS000754
AIDS115928
AIDS225806
BSPBio_003067
C06456
Carboxyphosphonic acid
CHEBI:127780
CHEMBL666
DB00529
dihydroxyphosphanecarboxylic acid oxide
Dihydroxyphosphinecarboxylic acid oxide
Dihydroxyphosphinecarboxylic acid oxide and MSL, neutralizing monoclonal
Dihydroxyphosphinecarboxylic acid oxide and MSL, neutralizing monoclonal antibody
DivK1c_000915
EHB 776
Formic acid, phosphono-
Forscarnet sodium
Foscarmet
Foscarnet
Foscarnet & IFN-.ALPHA.
Foscarnet sodium
Foscavir
IDI1_000915
KBio1_000915
KBio2_001839
KBio2_004407
KBio2_006975
KBio3_002567
KBioGR_001419
KBioSS_001839
LS-183979
LS-187063
LS-187793
MSL & PFA
NChemBio.2007.9-comp7
NINDS_000915
NSC313410
NSC313410 (SODIUM SALT)
PFA
PFA & rIFN.alpha.A
PFT
Phgosphonocarboxylic acid
Phosphinecarboxylic acid, dihydroxy-, oxide
Phosphonoformate
Phosphonoformate(trisodium) & Recombinant Alpha-A Interferon
Phosphonoformic acid
Phosphonoformic acid & IFN-.ALPHA.
phosphonomethanoic acid
PPF
SPBio_000735
Spectrum2_000668
Spectrum3_001484
Spectrum4_000840
Spectrum5_000932
Spectrum_001359
Triapten
UNII-364P9RVW4X
ATC-Codes:

Target

show target details
Uniprot ID:POKL_HUMAN
Synonyms:
Putative HERV-K_Xq28 provirus ancestral Pol protein
EC-Numbers:2.7.7.49
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

1371038
Mechanism of action of foscarnet against viral polymerases.. C S Crumpacker (1992) The American journal of medicine display abstract
Foscarnet is a pyrophosphate analogue with activity against herpesviruses, human immunodeficiency virus (HIV), and other RNA and DNA viruses. Foscarnet and its analogues achieve their antiviral effects via inhibition of viral polymerases, with such inhibition not being dependent on activation or phosphorylation of the compounds by viral or cellular proteins. Current evidence indicates that foscarnet interferes with exchange of pyrophosphate from deoxynucleoside triphosphate during viral replication by binding to a site on the herpesvirus DNA polymerase or HIV reverse transcriptase. Reviewed herein are basic findings regarding the mechanism of action and antiviral activity of foscarnet and the related compound phosphonoacetic acid (PAA), as well as findings regarding potential mechanisms of viral resistance and interactions with other antiviral agents.