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Drug-Target Interaction

Drug

show drug details
PubChem ID:3394
Structure:
Synonyms:
"(+/-)-2-fluoro-alpha-methyl[1,1′-biphenyl]-4-acetic acid"
(+)-2-(2-fluoro-4-biphenylyl)propionic acid
(+)-2-fluoro-alpha-methyl-4-biphenylacetic acid
(+-)-2-(2-Fluoro-4-biphenylyl)propionic acid
(+-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid
(+/-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid
(+/-)-2-Fluoro-alpha-methyl[1,1′-biphenyl]-4-acetic Acid
(1)-2-Fluoro-alpha-methyl(1,1'-biphenyl)-4-acetic acid
(1,1'-Biphenyl)-4-acetic acid, 2-fluoro-alpha-methyl-
(1,1'-biphenyl)-4-acetic acid, 2-fluoro-alpha-methyl-, (+)-
(1,1'-Biphenyl)-4-acetic acid, 2-fluoro-alpha-methyl-, (+-)-
2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid
2-(2-fluorobiphenyl-4-yl)propanoic acid
2-(2-Fluorobiphenyl-4-yl)propionic Acid
2-(3-fluoro-4-phenylphenyl)propanoic acid
2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid
2-Fluoro-alpha-methyl-4-biphenylacetic acid
3-Fluoro-4-phenylhydratropic acid
4-Biphenylacetic acid, 2-fluoro-alpha-methyl-
5104-49-4
51543-38-5
AB00051999
AC-12003
AC1L1FU5
AC1Q1LGF
Adfeed
Adofeed
AKOS004119934
Anmetarin
Ansaid
Ansaid (TN)
Anside
Antadys
Apo-Flurbiprofen
BB_SC-1257
BIM-0051387.0001
BPBio1_000874
BRD-A86044036-001-05-9
BSPBio_000794
BSPBio_002050
BTS 18322
BTS-18322
C15H13FO2
CCG-100759
CCG-40243
CCRIS 3708
Cebutid
CHEBI:5130
CHEMBL563
CPD000042823
D00330
DB00712
DivK1c_000804
EINECS 225-827-6
EINECS 257-262-6
F0371
F8514_SIGMA
FLP
Flubiprofen
Flugalin
FLURBIPROFEN
Flurbiprofen (JP15/USP/INN)
Flurbiprofen (JP16/USP/INN)
Flurbiprofen [USAN:BAN:INN:JAN]
Flurbiprofen [USAN:INN:BAN:JAN]
Flurbiprofene
Flurbiprofene [INN-French]
Flurbiprofeno
Flurbiprofeno [INN-Spanish]
Flurbiprofenum
Flurbiprofenum [INN-Latin]
Fluriproben
Flurofen
FP 70
Froben
Froben Sr
HMS1570H16
HMS1920O20
HMS2051A05
HMS2090I06
HMS2091F21
HMS2097H16
HMS2232I08
HMS3259I12
HMS502I06
IDI1_000804
IN1332
KBio1_000804
KBio2_001576
KBio2_004144
KBio2_006712
KBio3_001270
KBioGR_001255
KBioSS_001576
L-790,330
LS-44091
MKS-11
MLS000028441
MLS000040873
MLS000758198
MLS001201729
MLS001401361
NCGC00018157-03
NCGC00018157-04
NCGC00018157-05
NCGC00018157-08
NCGC00025287-03
NCGC00025287-04
NCI60_030812
NINDS_000804
Novo-Flurprofen
NSC685699
NSC685700
Nu-Flurbiprofen
Ocufen
Ocuflur
Prestwick0_000917
Prestwick1_000917
Prestwick2_000917
Prestwick3_000917
R-Flurbiprofen
S-Flurbiprofen
SAM001246961
SAM002564209
SMR000042823
SPBio_001209
SPBio_002983
SPECTRUM1500308
Spectrum2_001025
Spectrum3_000435
Spectrum4_000558
Spectrum5_000720
Spectrum_001096
Stayban
STK802101
SYTBZMRGLBWNTM-UHFFFAOYSA-
U 27,182
U 27182
U-27182
UNII-5GRO578KLP
Yakuban
Zepolas
[+/-]-2-Fluoro-alpha-methyl-4-biphenylacetic acid
[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-.alpha.-methyl-
[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-.alpha.-methyl-, (R)-
ATC-Codes:
Side-Effects:
Side-EffectFrequency
bleeding0.0010
nail disorder0.0010
nausea0.0010
interstitial nephritis0.0010
nervousness0.0010
neuritis0.0010
neutropenia0.0010
palpitations0.0010
pancreatitis0.0010
pancytopenia0.0010
paresthesia0.0010
peptic ulcer disease0.0010
periodontal abscess0.0010
pneumonia0.0010
pruritus0.0010
myocardial infarction0.0010
aseptic meningitis0.0010
meningitis0.0010
hepatitis0.0010
herpes simplex0.0010
zoster0.0010
hyperglycemia0.0010
hyperkalemia0.0010
hypertension0.0010
hypotension0.0010
infection0.0010
inflammatory bowel disease0.0010
ischemia0.0010
jaundice0.0010
laryngitis0.0010
leukopenia0.0010
melena0.0010
pulmonary embolism0.0010
purpura0.0010
retinal hemorrhage0.0010
vulvovaginitis0.0010
dry mouth0.0010
chills0.0010
liver failure0.0010
dry skin0.0010
iron deficiency anemia0.0010
malaise0.0010
sepsis0.0010
elevated liver enzymes0.0010
rectal bleeding0.0010
photosensitivity0.0010
lymphadenopathy0.0010
hyperuricemia0.0010
insomnia0.0010
vomiting0.0010
vasculitis0.0010
vascular diseases0.0010
rhinitis0.0010
convulsion0.0010
stevens johnson syndrome0.0010
stomatitis0.0010
cerebrovascular accident0.0010
subarachnoid hemorrhage0.0010
sweating0.0010
syncope0.0010
tachycardia0.0010
thrombocytopenia0.0010
tremor0.0010
ulcers0.0010
urticaria0.0010
uterine hemorrhage0.0010
hearing loss0.0010
abdominal pain0.0010
colitis0.0010
coma0.0010
confusion0.0010
constipation0.0010
corneal opacity0.0010
exfoliative dermatitis0.0010
diarrhea0.0010
somnolence0.0010
dyspepsia0.0010
dyspnea0.0010
ecchymosis0.0010
eczema0.0010
edema0.0010
cholecystitis0.0010
bronchitis0.0010
ataxia0.0010
agranulocytosis0.0010
alopecia0.0010
amnesia0.0010
anaphylactic reaction0.0010
anemia0.0010
aplastic anemia0.0010
hemolytic anemia0.0010
angina pectoris0.0010
angioedema0.0010
anxiety0.0010
arrhythmias0.0010
asthenia0.0010
asthma0.0010
eosinophilia0.0010
toxic epidermal necrolysis0.0010
glossitis0.0010
congestive heart failure0.0010
hallucinations0.0010
fever0.0010
flatulence0.0010
headache0.0010
gi bleeding0.0010
gastritis0.0010
heartburn0.0010
glaucoma0.0010
hematemesis0.0010
rash0.0010
epistaxis0.0010
erythema multiforme0.0010
eructation0.0010
anorexia0
gingivitis0
influenza0
arthritis0
vertigo0
blepharitis0
gastroenteritis0
arthrosis0
vaginitis0
emotional lability0
bleeding diathesis0
cerebral ischemia0
albuminuria0
amblyopia0
migraine0
heart failure0
right heart failure0
myalgia0
allergic reaction0
impotence0
photophobia0
urinary tract infection0
urinary incontinence0
urethritis0
renal failure0
pyuria0
diplopia0
dizziness0
proteinuria0
polyuria0
hematuria0
phlebitis0
pharyngitis0
petechiae0
euphoria0
esophagitis0
dysuria0
fibrosis0
decreased libido0
scleritis0
keratoconjunctivitis0
kidney calculus0
tinnitus0
tenosynovitis0
leukocytosis0
conjunctivitis0
lung disorder0
convulsions0
breast pain0
cough0
sinusitis0
cystitis0
seborrhea0
neuralgia0

Target

show target details
Uniprot ID:A4_HUMAN
Synonyms:
ABPP
Alzheimer disease amyloid protein
Amyloid beta A4 protein
APP
APPI
Cerebral vascular amyloid peptide
CVAP
PN-II
PreA4
Protease nexin-II
EC-Numbers:-
Organism:Homo sapiens
Human
PDB IDs:1AAP 1AMB 1AMC 1AML 1BA4 1BA6 1BJB 1BJC 1BRC 1CA0 1HZ3 1IYT 1MWP 1OWT 1QCM 1QWP 1QXC 1QYT 1RW6 1TAW 1TKN 1UO7 1UO8 1UOA 1UOI 1X11 1Z0Q 1ZE7 1ZE9 1ZJD 2BEG 2BOM 2BP4 2FJZ 2FK1 2FK2 2FK3 2FKL 2FMA 2G47 2IPU 2OTK 2R0W 3DXC 3DXD 3DXE 3GCI
Structure:
3GCI

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--305000-

References: