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Drug-Target Interaction

Drug

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PubChem ID:3314
Structure:
Synonyms:
1,3,4-Eugenol
1-Allyl-3-methoxy-4-hydroxybenzene
1-allyl-4-hydroxy-3-methoxybenzene
1-Hydroxy-2-methoxy-4-allylbenzene
1-Hydroxy-2-methoxy-4-prop-2-enylbenzene
1-hydroxy-2-methoxy-4-propenylbenze ne
1-Hydroxy-2-methoxy-4-propenylbenzene
1-hydroxy-4-allyl-2-methoxybenzene
2-Hydroxy-5-allylanisole
2-Methoxy-1-hydroxy-4-allylbenzene
2-Methoxy-4-(2-propen-1-yl)phenol
2-Methoxy-4-(2-propenyl)phenol
2-Methoxy-4-(3-propenyl)phenol
2-methoxy-4-(prop-2-en-1-yl)phenol
2-Methoxy-4-allylphenol
2-Methoxy-4-prop-2-enylphenol
2-Methoxy-4-[2-propenyl]phenol
2-Metoksy-4-allilofenol
2-Metoksy-4-allilofenol [Polish]
35995_FLUKA
35995_RIEDEL
4 -allyl-1-hydroxy-2-methoxybenzene
4-06-00-06337 (Beilstein Handbook Reference)
4-Allyl-1-Hydroxy-2-Methoxy Benzene
4-Allyl-1-hydroxy-2-methoxybenzene
4-Allyl-2-methoxyphenol
4-Allylcatechol 2-methyl ether
4-Allylcatechol-2-methyl ether
4-Allylguaiacol
4-Allylguaicol
4-Hydroxy-3-methoxy-1-allylbenzene
4-Hydroxy-3-methoxyallylbenzene
46100_FLUKA
5-Allylguaiacol
97-53-0
A0232
AC1L1FNK
AC1Q46B0
AC1Q7AE5
AI3-00086
AIDS-002235
AIDS002235
AKOS000121354
Allylguaiacol
AR-1J0704
BIDD:ER0696
Bio-0581
bmse010053
BRN 1366759
BSPBio_002251
C10453
C10H12O2
Caryophyllic ac id
Caryophyllic acid
Caswell No. 456BC
CCG-38827
CCRIS 306
CHEBI:4917
CHEMBL42710
CPD-6481
D005054
D04117
DivK1c_000692
E51791_ALDRICH
EINECS 202-589-1
Engenol
EPA Pesticide Chemical Code 102701
Eugenic acid
Eugenol
Eugenol (natural)
Eugenol (USP)
Eugenol Special
Eugenol [USAN]
FA 100
FEMA No. 2467
FEMA Number 2467
HMS1920O08
HMS2091F09
HMS502C14
HSDB 210
I01-7260
I01-8770
IDI1_000692
KBio1_000692
KBio3_001471
KBioGR_002327
LS-2027
MLS000028901
MolPort-001-783-095
NCGC00091449-01
NCGC00091449-02
NCGC00091449-03
NCGC00091449-04
NCGC00091449-05
NCGC00091449-06
NCGC00091449-07
NCGC00091449-08
NCI-C50453
NINDS_000692
NSC 209525
NSC209525
NSC8895
p-Allylguaiacol
p-Eugenol
Phenol, 2-methoxy-4-(2-propen-1-yl)-
Phenol, 2-methoxy-4-(2-propenyl)-
Phenol, 4-allyl-2-methoxy-
SBB012362
SDCCGMLS-0066578.P001
SMR000059114
SPBio_001228
SPECTRUM1500296
Spectrum2_001264
Spectrum3_000646
Spectrum4_001783
Spectrum5_000425
ST069318
Synthetic eugenol
UNII-3T8H1794QW
W246700_ALDRICH
W246719_ALDRICH
WLN: 1U2R DQ CO1
ZINC00001411

Target

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Uniprot ID:NOS2_MOUSE
Synonyms:
Inducible NO synthase
Inducible NOS
iNOS
MAC-NOS
Macrophage NOS
Nitric oxide synthase, inducible
NOS type II
EC-Numbers:1.14.13.39
Organism:Mouse
Mus musculus
PDB IDs:1DD7 1DF1 1DWV 1DWW 1DWX 1JWJ 1JWK 1M8D 1M8E 1M8H 1M8I 1M9T 1N2N 1NOC 1NOD 1NOS 1QOM 1QW4 1QW5 1R35 1VAF 2BHJ 2NOD 2NOS 2ORO 2ORP 2ORQ 2ORR 2ORS 2ORT 3DWJ 3E65 3E67 3E68 3E6L 3E6N 3E6O 3E6T 3E7I 3E7M 3E7T 3EAI 3EBD 3EBF 3NOD
Structure:
3NOD

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

16707845
Inhibitory action of eugenol compounds on the production of nitric oxide in RAW264.7 macrophages.. Weihua Li; Ryoko Tsubouchi; Shanlou Qiao; Miyako Haneda; Keiko Murakami; Masataka Yoshino (2006) Biomedical research (Tokyo, Japan) display abstract
Effects of eugenol compounds on the production of nitric oxide (NO) in RAW264.7 macrophages were analyzed in relation to the anti-inflammatory action of these compounds. Eugenol and isoeugenol inhibited lipopolysaccharide (LPS)-dependent production of NO, which was due to the inhibition of protein synthesis of inducible nitric oxide synthase (iNOS). Isoeugenol showed the most effective inhibitory effect and eugenol was less effective. LPS-dependent expression of cyclooxygenase-2 (COX-2) protein was also inhibited markedly by isoeugenol, and less effectively by eugenol. Anti-inflammatory action of eugenol compounds may be explained by the inhibition of NO production and COX-2 expression, the pro-inflammatory mediators.