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Drug-Target Interaction

Drug

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PubChem ID:3203
Structure:
Synonyms:
(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BEN
154635-17-3
177530-93-7
2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-
2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (+-)-
6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-3-one
6-Chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
BB_SC-1871
C14H9ClF3NO2
DMP 266
DMP-266
EFAVIRENZ
L 741211
L 743,726
L 743726
L-743,726
L-743726
LS-173466
MLS001304019
NCGC00159337-02
NCGC00159337-03
SMR000718784
Stocrin
SUSTIVA
Side-Effects:
Side-EffectFrequency
rash0.106603764
dizziness0.06
pruritus0.05
diarrhea0.03
abdominal pain0.03
nausea0.02
anorexia0.02
headache0.02
fatigue0.02
pain0.015749998
psychosis0.0010
rhabdomyolysis0.0010
thrombocytopenia0.0010
stevens - johnson syndrome0.0010
tachycardia0.0010
syncope0.0010
proteinuria0.0010
pancytopenia0.0010
neuralgia0.0010
neurosis0.0010
palpitations0.0010
pancreatitis0.0010
neuropathy0.0010
paresis0.0010
paresthesia0.0010
peripheral neuropathy0.0010
polyuria0.0010
thrombophlebitis0.0010
tinnitus0.0010
malaise0.0010
myalgia0.0010
hepatitis c antibody positive0.0010
blurred vision0.0010
photosensitivity0.0010
increased sweating0.0010
acne0.0010
paranoia0.0010
polyarthritis0.0010
muscle weakness0.0010
migraine headaches0.0010
tremor0.0010
urticaria0.0010
abnormal vision0.0010
verruca0.0010
dry mouth0.0010
hepatic failure0.0010
agitation0.0010
peripheral edema0.0010
allergic reaction0.0010
alopecia0.0010
constipation0.0010
convulsions0.0010
delirium0.0010
dermatitis0.0010
diplopia0.0010
dyspnea0.0010
eczema0.0010
erythema multiforme0.0010
confusion0.0010
chest pain0.0010
ataxia0.0010
amnesia0.0010
anemia0.0010
anxiety0.0010
apnea0.0010
arrhythmia0.0010
arthralgia0.0010
asthenia0.0010
asthma0.0010
erythema nodosum0.0010
fever0.0010
hypersensitivity reaction0.0010
hypertension0.0010
hypertriglyceridemia0.0010
influenza0.0010
iritis0.0010
jaundice0.0010
malabsorption0.0010
myopathy0.0010
nail disorders0.0010
hypercholesterolemia0.0010
hepatomegaly0.0010
flank pain0.0010
flushing0.0010
folliculitis0.0010
glaucoma0.0010
gynecomastia0.0010
hallucination0.0010
congestive heart failure0.0010
hepatitis0.0010
hepatitis b0.0010
hiv infection0
vomiting0
insomnia0
tuberculosis0
lightheadedness0
exfoliative dermatitis0
elevated liver enzymes0
stupor0
manic0
thinking abnormal0
depersonalization0
emotional lability0
euphoria0
delusions0
apathy0
toxic epidermal necrolysis0
somnolence0
obesity0
cachexia0
cancer0
malformations0
pneumonia0
cough0
blistering0
lipoma0
cleft palate0
breast enlargement0
concentration impaired0
lipodystrophy0
nervousness0
ulcer0
dyspepsia0
erythema0

Target

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Uniprot ID:CP2C9_HUMAN
Synonyms:
(R)-limonene 6-monooxygenase
(S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase
CYPIIC9
Cytochrome P450 2C9
P-450MP
P450 MP-4/MP-8
P450 PB-1
S-mephenytoin 4-hydroxylase
EC-Numbers:1.14.13.48
1.14.13.49
1.14.13.80
Organism:Homo sapiens
Human
PDB IDs:1OG2 1OG5 1R9O
Structure:
1R9O

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: