Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:3152
Structure:
Synonyms:
1-BENZYL-4-((5,6-DIMETHOXY-1-INDANON)-2-YL)-METHYLPIPERIDINE HYDROCHLORIDE,DL-
110119-84-1
120011-70-3
120014-06-4
142057-79-2
1H-Inden-1-one,
1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-
5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methyl]-2,3-dihydroinden-1-one
Aricept
C24H29NO3
CHEBI:53289
DB00843
Donepezil
Donepezil [INN:BAN]
Eranz
KBio2_002144
KBio2_004712
KBio2_007280
KBioSS_002144
LS-81819
NCGC00167537-01
Oprea1_188452
SL-00730
Spectrum5_001662
Spectrum_001664
TL8000531
ATC-Codes:
Side-Effects:
Side-EffectFrequency
gastrointestinal bleeding1.0
pruritus1.0
dehydration1.0
convulsion1.0
toothache1.0
cough1.0
constipation1.0
tremor1.0
urinary incontinence1.0
chest pain1.0
paresthesia1.0
nocturia1.0
nervousness1.0
glycosuria1.0
heart failure1.0
hot flashes1.0
hypertension1.0
hypotension1.0
influenza1.0
fecal incontinence1.0
dyspepsia1.0
fungal infection1.0
urinary tract infection1.0
epigastric pain1.0
sore throat1.0
anxiety1.0
arthritis1.0
asthenia1.0
vision blurred1.0
ecg abnormal1.0
alkaline phosphatase increased1.0
diaphoresis1.0
lactic dehydrogenase increased1.0
bloating1.0
abdominal pain1.0
cataract1.0
peripheral edema1.0
bronchitis1.0
restlessness1.0
weight loss1.0
aphasia1.0
urticaria0.6700001
atrial fibrillation0.6700001
ataxia0.66999996
dyspnea0.66999996
vertigo0.66999996
rash0.505
pneumonia0.34
gait abnormality0.34
bradycardia0.34
pharyngitis0.34
skin ulcer0.34
gastroenteritis0.34
hematuria0.34
cystitis0.34
anemia0.34
edema0.34
insomnia0.099999994
nausea0.06799998
diarrhea0.06416666
muscle cramps0.051428564
fatigue0.049999997
anorexia0.043999996
vomiting0.03799999
dry skin0.01
ventricular extrasystoles0.01
myalgia0.01
neurodermatitis0.01
liver function tests abnormal0.01
osteoporosis0.01
malaise0.01
muscle weakness0.01
conjunctivitis0.01
periodontitis0.01
thrombocytopenia0.01
sweating0.01
cerebral infarction0.01
abnormal vision0.01
supraventricular extrasystoles0.01
increased salivation0.01
dysphagia0.01
rhinitis0.01
cerebral hemorrhage0.01
asthma0.01
wheezing0.01
psoriasis0.01
fungal dermatitis0.01
leukocytosis0.01
leg cramps0.01
lacrimation disorder0.01
grand mal convulsion0.01
myocardial infarction0.01
hemiplegia0.01
urinary frequency0.01
cerebral ischemia0.01
hernia0.01
cardiomegaly0.01
albuminuria0.01
epistaxis0.01
esophagitis0.01
dementia0.01
allergic reaction0.01
arthrosis0.01
arthralgia0.01
prostate hypertrophy0.01
sepsis0.01
rectal hemorrhage0.01
abscess0.009999999
weight increase0.009999999
hyperkeratosis0.009999999
paranoia0.009999999
cholelithiasis0.009999999
dysphasia0.009999999
decreased hearing0.009999999
transient ischemic attack0.009999999
vaginitis0.009999999
jaundice0.009999999
cellulitis0.009999999
dry mouth0.009999999
hypoxia0.009999999
arteritis0.009999999
dry eyes0.009999999
angina pectoris0.009999999
pulmonary collapse0.009999999
intracranial hemorrhage0.009999999
alopecia0.009999999
deep vein thrombosis0.009999999
av block0.009999999
pyuria0.009999999
blepharitis0.009999999
urinary urgency0.009999999
polydipsia0.009999999
chills0.009999999
peripheral vascular disease0.009999999
thrombocythemia0.009999999
skin striae0.009999999
erythema0.009999999
fibrocystic breast0.009999999
hirsutism0.009999999
eosinophilia0.009999999
hyperglycemia0.009999999
enuresis0.009999999
hypokalemia0.009999999
postural hypotension0.009999999
ear pain0.009999999
irritable colon0.009999999
dysuria0.009999999
mastitis0.009999999
melena0.009999999
herpes zoster0.009999999
fever sore0.009999999
flatulence0.009999999
gastritis0.009999999
gingivitis0.009999999
glaucoma0.009999999
eructation0.009999999
goiter0.009999999
gout0.009999999
congestive heart failure0.009999999
hemorrhage0.009999999
hemorrhoids0.009999999
hernia hiatal0.009999999
metrorrhagia0.009999999
tinnitus0.009999999
post nasal drip0.009999999
dermatitis0.009999999
pyelonephritis0.009999999
renal failure0.009999999
retinal hemorrhage0.009999999
decreased libido0.009999999
sleep apnea0.009999999
muscle spasm0.009999999
stomach ulcer0.009999999
cerebrovascular accident0.009999999
supraventricular tachycardia0.009999999
pleurisy0.009999999
diabetes mellitus0.009999999
motion sickness0.009999999
dysarthria0.009999999
fever0.009999999
duodenal ulcer0.009999999
neuralgia0.009999999
night sweats0.009999999
numbness0.009999999
periodontal abscess0.009999999
otitis media0.009999999
otitis externa0.009999999
nystagmus0.009999999
diverticulitis0.009999999
osteoarthritis0
hepatitis0
pancreatitis0
infection0
somnolence0
ecchymosis0
b12 deficiency anemia0
convulsions0
cyst0
hallucinations0
apathy0
delusions0
dysphoria0
emotional withdrawal0
irritability0
emotional lability0
euphoria0
headache0
hypercholesterolemia0
sgot increased0
back pain0
bilirubinemia0
confusion0
hemolytic anemia0
hyponatremia0
arrhythmia0
pain0
syncope0
eczema0
hypoglycemia0
dizziness0
nasopharyngitis0
cachexia0
iron deficiency anemia0
heart block0
hyperlipidemia0
personality disorder0
cholecystitis0

Target

show target details
Uniprot ID:ACES_RAT
Synonyms:
Acetylcholinesterase
AChE
EC-Numbers:3.1.1.7
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--1.7-
--5.7-
--7.86-
--12-
--16-
--20-
--26.8-
--40-

References: