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Drug-Target Interaction

Drug

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PubChem ID:3117
Structure:
Synonyms:
1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane
1,1',1'',1'''-[dithiobis(carbonothioylnitrilo)]tetraethane
1,1'-Dithiobis(N,N-diethylthioformamide)
1,1'-Dithiobis[N,N-diethylthioformamide]
11078-22-1
155-01-1
86720_ALDRICH
86720_FLUKA
97-77-8
AB00051976
Abstenisil
Abstensil
Abstensyl (Argentina)
Abstinil
Abstinyl
AC1L1F7H
AC1Q2YXI
Accel TET
Accel TET-R
AI3-27340
AIDS-010293
AIDS010293
AKOS000120201
Akrochem TETD
Alcophobin
Alk-Aubs
Allphar Brand of Disulfiram
Altana Pharma Brand of Disulfiram
Ancazide ET
Antab use
Antabus
Antabuse
Antabuse (TN)
Antabuse, Antabus, Disulfiram
Antadix
Antaenyl
Antaethan
Antaethyl
Antaetil
Antalcol
Antetan
Antethyl
Antetil
Anteyl
Anthethyl
anti-Ethyl
Antiaethan
Anticol
Antietanol
Antiethanol
Antietil
Antikol
Antivitium
Antivitium (Spain)
ARONIS24121
Artu Brand of Disulfiram
Aversan
Averzan
B0479
Bis((diethylamino)thioxomethyl) disulfide
bis((diethylamino)thioxomethyl)disulfide
Bis((diethylamino)thioxomethyl)disulphide
Bis(diethylthiocarbamoyl) disulfide
Bis(diethylthiocarbamoyl)disulphide
Bis(diethylthiocarbamyl) disulfide
Bis(N,N-diethylthiocarbamoyl) disulfide
Bis(N,N-diethylthiocarbamoyl)disulphide
bis-(diethylthiocarbamoyl)disulfide
Bis[(diethylamino)thioxomethyl] disulfide
Bohm Brand of Disulfiram
Bonibal
BPBio1_000060
BRD-K32744045-001-05-6
BSPBio_000054
BSPBio_001930
C01692
C10H20N2S4
CAS-97-77-8
CCG-39549
CCRIS 582
CHEBI:4659
CHEMBL964
Contralin
Contrapot
CPD000059171
Cronetal
D00131
D004221
DB00822
Dicupral
diethylcarbamothioylsulfanyl diethylaminomethanedithioate
diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate
Disetil
Disulfamide
Disulfan
Disulfide, bis(diethylthiocarbamoyl)
Disulfide, Tetraethylthiuram
Disulfiram
Disulfiram (JP15/USP/INN)
Disulfiram (JP16/USP/INN)
DISULFIRAM (TETRAETHYLTHIURAM DISULFIDE)
Disulfiram [BAN:INN:JAN]
Disulfiram [INN:BAN:JAN]
Disulfiram-Supplied by Selleck Chemicals
Disulfirame
Disulfirame [DCIT]
Disulfiramo
Disulfiramo [INN-Spanish]
Disulfiramum
Disulfiramum [INN-Latin]
Disulfirm
Disulfram
Disulfuram
Disulphuram
DRG-0068
Dumex Brand of Disulfiram
Dupon 4472
Dupont fungicide 4472
EINECS 202-607-8
Ekagom DTET
Ekagom TEDS
Ekagom TETDS
Ekaland TETD
ENT 27,340
Ephorran
Espenal
Esperal
Esperal [France]
Eta bus
Etabus
Ethyl Thiram
Ethyl Thiudad
Ethyl Thiurad
Ethyl tuads
Ethyl Tuads Rodform
Ethyl Tuex
Ethyldithiourame
Ethyldithiurame
Etyl Tuex
EU-0101164
Exhoran
Exhorran
Formamide, 1,1'-dithiobis(N,N-diethylthio)-
Formamide, 1,1'-dithiobis(N,N-diethylthio-
Gababentin
HMS1568C16
HMS1920I16
HMS2051M17
HMS2090C18
HMS2091O22
HMS2095C16
HMS2230K06
HMS3263J09
Hoca
Hocakrotenalnci-C02959
HSDB 3317
KBio2_001490
KBio2_004058
KBio2_006626
KBio3_001150
KBioGR_000895
KBioSS_001490
Krotenal
Lopac-T-1132
Lopac0_001164
LS-2031
MLS000069818
MLS000758264
MLS001076475
N,N,N',N'-Tetraethylthiuram disulfide
N,N,N',N'-Tetraethylthiuram disulphide
NCGC00016000-01
NCGC00016000-02
NCGC00016000-03
NCGC00016000-04
NCGC00016000-05
NCGC00016000-06
NCGC00016000-07
NCGC00016000-08
NCGC00016000-09
NCGC00016000-10
NCGC00016000-11
NCGC00016000-12
NCGC00016000-13
NCGC00016000-14
NCGC00016000-15
NCGC00094423-01
NCGC00094423-02
NCGC00094423-03
NCGC00094423-05
NCGC00094423-06
NCGC00094423-07
nchembio.559-comp2
NCI-C02959
Nocbin
Nocceler
Nocceler TET
Nocceler TET-G
Noxal
Noxal (VAN)
NSC 190940
NSC 25953
NSC-25953
NSC25953
Odyssey Brand of Disulfiram
Orphan Brand of Disulfiram
Perkacit TETD
Perkait TETD
Prestwick0_000097
Prestwick1_000097
Prestwick2_000097
Prestwick3_000097
Prestwick_182
Refusal
Refusal [Netherlands]
Ro-Sulfiram
Ro-Sulfram-500 (USA)
Robac TET
S00294
S1680_Selleck
SAM001247028
Sanceler TET
Sanceler TET-G
Sanofi Synthelabo Brand of Disulfiram
SBB058706
SMR000059171
Soxinol TET
SPBio_001191
SPBio_001993
SPECTRUM1500262
Spectrum2_001176
Spectrum3_000405
Spectrum4_000228
Spectrum5_001590
Spectrum_001010
STL069539
Stopaethyl
Stopethyl
Stopety
Stopetyl
T 1132
T1132_SIGMA
TATD
Tenurid
Tenutex
tet raethylthiuram
TETD
Tetidis
Tetradin
Tetradine
Tetraethylthioperoxydicarbonic diamide
Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2
Tetraethylthioperoxydicarbonothioic Diamide
Tetraethylthiram disulfide
Tetraethylthiram disulphide
Tetraethylthiuram
Tetraethylthiuram disulfide
Tetraethylthiuram disulphide
Tetraethylthiuram sulfide
Tetraethylthiuran disulfide
Tetraethylthiurium disulfide
Tetraetil
Teturam
Teturamin
Thiocid
Thioperoxydicarbonic diamide (((H2N)C(S))2S2), N,N,N',N'-tetraethyl-
Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-
Thioperoxydicarbonic diamide ((H2N)C(S))2S2, tetraethyl-
Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetraethyl-
Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetraethyl-
Thioperoxydicarbonic diamide, tetraethyl-
Thiosan
Thioscabin
Thireranide
Thiuram disulfide, tetraethyl-
Thiuram E
Thiuranide
Tillram
Tiuram
TTD
TTS
TTS x
TTS [Alcohol deterrent]
Tuads, ethyl
UNII-TR3MLJ1UAI
UPCMLD-DP090
UPCMLD-DP090:001
Usaf B-33
WLN: 2N2 & YUS & S 2
ZINC01529266
ATC-Codes:
Side-Effects:
Side-EffectFrequency
hepatitis0
neuritis0
peripheral neuropathy0
polyneuritis0
psychosis0
hepatic failure0
impotence0
optic neuritis0
atopic dermatitis0
somnolence0
headache0

Target

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Uniprot ID:CP1A2_HUMAN
Synonyms:
CYPIA2
Cytochrome P450 1A2
P(3)450
P450 4
P450-P3
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:2HI4
Structure:
2HI4

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----

References:

11851639
Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects.. Reginald F Frye; Robert A Branch (2002) British journal of clinical pharmacology display abstract
AIMS: Short-term disulfiram administration has been shown to selectively inhibit CYP2E1 activity but the effects of chronic disulfiram administration on the activities of drug metabolizing enzymes is unclear. The purpose of this study was to evaluate the effects of disulfiram given for 11 days on selected drug metabolizing enzyme activities. METHODS: Seven healthy volunteers were given disulfiram 250 mg daily for 11 days. Activities of the drug metabolizing enzymes CYP1A2, CYP2C19, CYP2D6, CYP2E1 and N-acetyltransferase were determined using the probe drugs caffeine, mephenytoin, debrisoquine, chlorzoxazone, and dapsone, respectively. Chlorzoxazone was administered before disulfiram administration and after the second and eleventh doses of disulfiram, while the other probe drugs were given before disulfiram administration and after the eleventh disulfiram dose. RESULTS: Disulfiram administration markedly inhibited chlorzoxazone 6-hydroxylation by more than 95%, but did not affect metabolism of debrisoquine or mephenytoin. Caffeine N3-demethylation was decreased by 34% (P < 0.05). Monoacetyldapsone concentrations were markedly elevated by disulfiram administration resulting in a nearly 16-fold increase in the dapsone acetylation index, calculated as the plasma concentration ratio of monoacetyldapsone to dapsone. CYP-mediated dapsone N-hydroxylation was not significantly altered. CONCLUSIONS: These data suggest that disulfiram-mediated inhibition is predominantly selective for CYP2E1. The magnitude of CYP2E1 inhibition was similar after both acute and chronic disulfiram administration. The effects on caffeine N3-demethylation (CYP1A2) and dapsone metabolism suggest that chronic disulfiram administration may affect multiple drug metabolizing enzymes, which could potentially complicate the use of chronically administered disulfiram as a diagnostic inhibitor of CYP2E1.
SuperCyp