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Drug-Target Interaction

Drug

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PubChem ID:3108
Structure:
Synonyms:
2,2',2'',2'''-((4,8-Dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetraethanol
2,2',2'',2'''-[(4,8-dipiperidin-1-ylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol
2,2',2'',2'''-[4,8-Dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilotetraethanol
2,2',2'',2'''-{[4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo}tetraethanol
2,2',2',2'''-((4,8-Dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetraethanol
2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido(5,4-d)pyrimidine
2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
2-[[2-(bis(2-hydroxyethyl)amino)-4,8-di(piperidin-1-yl)pyrimido[6,5-e]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol
4-26-00-03840 (Beilstein Handbook Reference)
58-32-2
AB00051974
AGGRENOX
Agilease
AIDS-029341
AIDS029341
Anginal
Antistenocardin
Apo-Dipyridamole
Apotex Brand of Dipyridamole
Apricor
Ashbourne Brand of Dipyridamole
BAS 00818792
Belmac Brand of Dipyridamole
Berlin Chemie Brand of Dipyridamole
Berlin-Chemie Brand of Dipyridamole
BIM-0050449.0001
Boehringer Ingelheim Brand of Dipyridamole
BPBio1_000270
BRN 0068373
BSPBio_000244
BSPBio_001554
BSPBio_001924
C24H40N8O4
Cardioflux
Cardoxin
CAS-58-32-2
Cerebrovase
CHEBI:4653
Chilcolan
Cl?ridium
Cleridium 150
Coribon
Coronarine
Corosan
Coroxin
Curantil
Curantyl
D00302
D004176
D9766_SIGMA
DB00975
Dipiridamol
Dipiridamol [INN-Spanish]
Dipyramidole
Dipyridamine
Dipyridamol
DIPYRIDAMOLE
Dipyridamole (JP15/USP/INN)
Dipyridamole [USAN:BAN:INN:JAN]
Dipyridamole [USAN:INN:BAN:JAN]
Dipyridamolum
Dipyridamolum [INN-Latin]
Dipyridan
Dipyudamine
DivK1c_000696
DPM
Dypyridamol
EINECS 200-374-7
Ethanol,
Ethanol, 2,2',2'',2'''-((4,8-di-1-piperidinylpyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetrakis-
Ethanol, 2,2',2'',2'''-((4,8-dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetra-
Ethanol, 2,2',2'',2'''-(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetra-
Ethanol, 2,2',2'',2'''-[(4,8-di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-
Ethanol, 2,2',2'',2'''-[(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetra-
Ethanol, 2,2',2',2'''-((4,8-di-1-piperidinylpyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetrakis-
EU-0100464
Gulliostin
IDI1_000696
IPRAD Brand of Dipyridamole
IV PERSANTINE
Justpertin
KBio1_000696
KBio2_001484
KBio2_004052
KBio2_006620
KBio3_001144
KBioGR_001123
KBioSS_001484
Kurantil
Lopac-D-9766
Lopac0_000464
LS-66732
Miosen
MLS000028420
MLS001076306
MLS001333724
Natyl
NCGC00015385-01
NCGC00015385-02
NCGC00015385-03
NCGC00023914-02
NCGC00023914-04
NCGC00023914-05
NCGC00023914-06
NCGC00023914-07
NCGC00023914-08
NCGC00023914-09
NCGC00023914-10
NCGC00023914-11
NCI60_005689
NINDS_000696
Novo-Dipiradol
Novopharm Brand of Dipyridamole
NSC 515776
NSC515776
NSC619103
Peridamol
Permiltin
Persantin
Persantine
Persantine (TN)
Piroan
Prandiol
Prandiol 75
Prestwick0_000142
Prestwick1_000142
Prestwick2_000142
Prestwick3_000142
Prestwick_145
Pyrimido(5,4-d)pyrimidine, 2,6-bis(bis(2-hydroxyethyl)amino)-4,8-dipiperidino-
Pyrimido(5,4-d)pyrimidine, 2,6-bis[bis(2-hydroxyethyl)amino]-4,8-diperidino-
RA 8
RA-8
SMP2_000208
SMR000058382
SPBio_001003
SPBio_002183
SPECTRUM1500259
Spectrum2_000972
Spectrum3_000402
Spectrum4_000522
Spectrum5_000839
Spectrum_001004
ST5240740
Stenocardil
Stenocardiol
Stimolcardio
Thymidine, 3'-azido-5-bromo-3'-deoxy-5,6-dihydro-6-methoxy-
Tocris-0691
UPCMLD-DP072
UPCMLD-DP072:001
USAF GE-12
WLN: T66 BN DN GN INJ CCN HCN E- AT6NTJ B2Q F2Q& J- AT6NTJ B2Q F2Q
ZINC00643046
ATC-Codes:
Side-Effects:
Side-EffectFrequency
dizziness0.12250001
headache0.01725
rash0.013666666
alopecia0.0010
nausea0.0010
palpitation0.0010
paresthesia0.0010
tachycardia0.0010
thrombocytopenia0.0010
urticaria0.0010
malaise0.0010
myalgia0.0010
hypotension0.0010
hypersensitivity0.0010
angioedema0.0010
arthritis0.0010
bronchospasm0.0010
cholelithiasis0.0010
dyspepsia0.0010
edema0.0010
fatigue0.0010
hepatitis0.0010
anxiety0
seizures0
arrhythmia0
dyspnea0
pain0
vomiting0
av block0
tinnitus0
diarrhea0
pleuritic pain0
vertigo0
chest pain0
claudication0
allergic reaction0
dysphagia0
flushing0
asthenia0
breast pain0
tenesmus0
supraventricular tachycardia0
atrial fibrillation0
syncope0
bradycardia0
pharyngitis0
tremor0
migraine0
somnolence0
depersonalization0
increased sweating0
kidney pain0
flatulence0
cough0
myocardial infarction0
arthralgia0
transient cerebral ischemia0
rhinitis0
cardiomyopathy0
ear pain0
back pain0
eructation0
hypertension0
nervousness0
hemorrhage0
angina pectoris0
postural hypotension0
ventricular fibrillation0
abdominal pain0
dry mouth0
ventricular tachycardia0
cardiac arrest0
dysphonia0
pruritus0
heart block0
eye pain0
dermatitis0
cerebrovascular accident0

Target

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Uniprot ID:PDE2A_HUMAN
Synonyms:
cGMP-dependent 3',5'-cyclic phosphodiesterase
CGS-PDE
cGSPDE
Cyclic GMP-stimulated phosphodiesterase
EC-Numbers:3.1.4.17
Organism:Homo sapiens
Human
PDB IDs:1Z1L
Structure:
1Z1L

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--3240-
--3600-

References: