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Drug-Target Interaction

Drug

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PubChem ID:3101
Structure:
Synonyms:
(1,1'-Biphenyl)-2,2'-diyliodonium
123773-57-9
2,2'-Biphenylyleneiodonium
244-54-2
244-54-2 (Parent)
4510-83-2
4510-83-2 (sulfate[2:1])
4843-42-9
AC1L1F68
AC1Q1HKF
AR-1I3885
Bio1_000428
Bio1_000917
Bio1_001406
Bio2_000344
Bio2_000824
Bis(dibenziodonium) sulphate
BRD-K65814004-001-02-3
BSPBio_001027
C12H8I
CCG-204462
CHEMBL365739
Dibenziodolium
dibenzo[b,d]iodolium
diphenyl-iodonium hydrochloride
Diphenylene iodonium
diphenyleneiodium chloride
Diphenyleneiodonium
Diphenyleneiodonium chloride
EINECS 224-829-4
HMS1362C09
HMS1792C09
HMS1990C09
IDI1_002099
KBio2_000367
KBio2_002935
KBio2_005503
KBio3_000713
KBio3_000714
KBioGR_000367
KBioSS_000367
Lopac-D-2926
Lopac0_000367
LS-174053
NCGC00015334-01
NCGC00015334-02
NCGC00015334-03
NCGC00015334-04
NCGC00015334-05
NCGC00015334-06
NCGC00015334-07
NCGC00024620-01
NCGC00024620-02
NCGC00024620-03
NCGC00024620-04
nchembio.83-comp19
nchembio873-comp33
QFXKXRXFBRLLPQ-UHFFFAOYSA-
QTL1_000031
Tocris-0504

Target

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Uniprot ID:DUOX1_RAT
Synonyms:
Dual oxidase 1
EC-Numbers:1.11.1.-
1.6.3.1
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

9780311
Prostaglandin f2alpha treatment in vivo, but not in vitro, stimulates protein kinase C-activated superoxide production by nonsteroidogenic cells of the rat corpus luteum.. R F Aten; T R Kolodecik; M J Rossi; C Debusscher; H R Behrman (1998) Biology of reproduction display abstract
Luteal regression is associated with the generation of reactive oxygen species (ROS). To determine the nature of the ROS generator, cells isolated from luteinized rat ovaries were examined for ROS production using luminol-amplified chemiluminescence (LCL). Cells cultured for 2-48 h exhibited minimal LCL, but there was a significant (30- to 50-fold), rapid (maximum at 3-5 min), and dose-dependent increase in LCL in response to phorbol ester (phorbol 12-myristate 13-acetate; TPA; ED50 = 0.03 microM) and diacylglycerol (1,2-dioctanoyl-glycerol; ED50 = 30 microM). The TPA-induced response was cell number dependent and was virtually abolished by superoxide dismutase, freezing, or heating (95 degrees C for 5 min). Zymosan, known to induce a phagocytic response in leukocytes, stimulated a superoxide (O2-.) response with a slow onset (maximum at 40 to 60 min) and a maximum about one third of that observed for TPA. The response to TPA and zymosan was inhibited by the NADPH/NADH-oxidase inhibitor, diphenylene iodonium (ID50 = 5 microM for TPA), but not by the mitochondrial inhibitors, potassium cyanide, rotenone, or sodium azide. Fractionation of cells by centrifugal elutriation showed that TPA-stimulated O2-. production coeluted with the nonsteroidogenic cells and that little, if any, O2-. generation coeluted with the steroidogenic cells. Cells isolated 1, 2, and 4 h after in vivo treatment with a luteolytic dose of prostaglandin F2alpha (PGF2alpha) showed a significant increase in TPA-stimulated O2-. production at 2 h, whereas luteal cells or corpora lutea incubated directly with 1 microM PGF2alpha did not show any increase in response. Corpora lutea isolated from naturally regressed ovaries (18 days after ovulation) showed a significantly elevated level of TPA-stimulated O2-. production. In conclusion, there is a superoxide generator in luteinized ovaries that is activated through a protein kinase C pathway, localized in nonsteroidogenic cells, transiently increased during PGF2alpha-induced luteolysis in vivo, and elevated during natural luteal regression.