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Drug-Target Interaction

Drug

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PubChem ID:3081361
Structure:
Synonyms:
2ivu
338992-00-0
4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]q
4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINE
4-Quninazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-
443913-73-3
AZD-6474
C452423
CHEBI:49960
D06407
LS-184394
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
NCGC00167513-01
vande-tanib
Vandetanib
Vandetanib (JAN/INN)
Vandetanib [INN]
Zactima
Zactima, ZD6474
ZD 6474
ZD-6474
ZD6
ZD6474

Target

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Uniprot ID:VGFR2_HUMAN
Synonyms:
CD309
Kinase insert domain receptor
Protein-tyrosine kinase receptor Flk-1
Vascular endothelial growth factor receptor 2
VEGFR-2
EC-Numbers:2.7.10.1
Organism:Homo sapiens
Human
PDB IDs:1VR2 1Y6A 1Y6B 1YWN 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH
Structure:
3EWH

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--<15-
--22-
--22-
--27.3-
--31.3-
--40-
--40-
--41.8-
--45-
-470--
--100-
-820--
--149.8-
--1660-
--4834-
--5980.5-

References: