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Drug-Target Interaction

Drug

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PubChem ID:3062316
Structure:
Synonyms:
(18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
1N1
2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302962-49-8
5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-
BCB03_000715
BMS 354825
BMS Dasatinib
BMS-354825
BMS354825
C488369
CHEBI:49375
D03658
Dasatinib
Dasatinib (USAN)
Dasatinib [USAN]
DB01254
LS-186641
LS-187028
LS-187773
N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-MET
N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE
N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, monohydrate
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
NCGC00181129-01
nchembio.117-comp11
nchembio.162-comp4
NSC-732517
NSC732517
Sprycel
Sprycel (TN)
ATC-Codes:
Side-Effects:
Side-EffectFrequency
muscle inflammation1.0
syncope1.0
gastritis1.0
thrombophlebitis1.0
tinnitus1.0
tremor1.0
urticaria1.0
vertigo1.0
erythema nodosum1.0
convulsion1.0
renal failure1.0
nail disorder1.0
infection1.0
hypotension1.0
palpitations1.0
pancytopenia1.0
hypertension1.0
hypersensitivity1.0
pneumonitis1.0
enterocolitis1.0
somnolence1.0
colitis1.0
malaise1.0
lung infiltration1.0
asthma1.0
pigmentation disorder1.0
urinary frequency1.0
angina pectoris1.0
hyperuricemia1.0
confusional state1.0
conjunctivitis1.0
dry skin1.0
dysphagia1.0
eczema1.0
muscular weakness1.0
dermatitis1.0
dry eye1.0
neutropenia0.58166665
thrombocytopenia0.50625
anemia0.34142858
diarrhea0.14
hypophosphatemia0.117142856
pleural effusion0.10699999
hemorrhage0.0723077
edema0.067499995
nausea0.067499995
hypocalcemia0.06666666
gastrointestinal bleeding0.04
dyspnea0.036666665
vomiting0.0325
elevated sgot0.025
pyrexia0.02
fatigue0.019999998
pericardial effusion0.017499998
congestive heart failure0.015999999
pulmonary edema0.015
headache0.015
abdominal pain0.013333333
musculoskeletal pain0.013333333
amnesia0.01
skin rash0.01
arrhythmia0.01
ventricular tachycardia0.01
esophagitis0.01
acute febrile neutrophilic dermatosis0.01
photosensitivity0.01
panniculitis0.01
coagulopathy0.01
bronchospasm0.01
libido decreased0.01
transient ischemic attack0.01
menstruation irregular0.01
ulcer0.01
anal fissure0.01
tumor0.01
pericarditis0.01
myocarditis0.01
proteinuria0.01
myocardial infarction0.01
cardiomegaly0.01
acute respiratory distress syndrome0.01
rhabdomyolysis0.01
skin ulcer0.01
cerebrovascular accident0.01
gynecomastia0.01
tendonitis0.01
pancreatitis0.01
ascites0.0066666664
pulmonary hypertension0.0066666664
aplasia pure red cell0.0010
milia0
anorexia0
breast disorders0
drug eruption0
dyspepsia0
liver function tests abnormal0
tachycardia0
heart disease0
mediastinal disorders0
skin irritation0
connective tissue disorders0
erythema multiforme0
upper respiratory tract infection0
arthralgia0
myalgia0
neuropathy0
anxiety0
sepsis0
insomnia0
abdominal distention0
lupus0
hepatitis0
vascular disorders0
stomatitis0
heart failure0
chills0
herpes0
flushing0
alopecia0
pain0
chest pain0
pruritus0
acne0
cholecystitis0
cough0
hyperhidrosis0
heat rash0
leukemia0
cardiomyopathy0
constipation0
weight gain0
weight loss0
peripheral neuropathy0
viral infection0
asthenia0
dizziness0
erythema0

Target

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Uniprot ID:MK10_HUMAN
Synonyms:
c-Jun N-terminal kinase 3
MAP kinase p49 3F12
Mitogen-activated protein kinase 10
Stress-activated protein kinase JNK3
EC-Numbers:2.7.11.24
Organism:Homo sapiens
Human
PDB IDs:1JNK 1PMN 1PMQ 1PMU 1PMV 2B1P 2EXC 2O0U 2O2U 2OK1 2P33 2R9S 2WAJ 2ZDT 2ZDU 3CGF 3CGO 3DA6 3FI2 3FI3 3FV8 3G90 3G9L 3G9N
Structure:
3G9N

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
->10000--

References: