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Drug-Target Interaction

Drug

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PubChem ID:3038525
Structure:
Synonyms:
209410-46-8
5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido(1,6-b)pyridazin-6-one
6H-Pyrimido(1,6-b)pyridazin-6-one,
6H-Pyrimido(1,6-b)pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)thio)-
VX-745
VX745, VX-745
ZINC13493055

Target

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Uniprot ID:VGFR2_HUMAN
Synonyms:
CD309
Kinase insert domain receptor
Protein-tyrosine kinase receptor Flk-1
Vascular endothelial growth factor receptor 2
VEGFR-2
EC-Numbers:2.7.10.1
Organism:Homo sapiens
Human
PDB IDs:1VR2 1Y6A 1Y6B 1YWN 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH
Structure:
3EWH

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
->10000--

References: