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Drug-Target Interaction

Drug

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PubChem ID:3038525
Structure:
Synonyms:
209410-46-8
5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido(1,6-b)pyridazin-6-one
6H-Pyrimido(1,6-b)pyridazin-6-one,
6H-Pyrimido(1,6-b)pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)thio)-
VX-745
VX745, VX-745
ZINC13493055

Target

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Uniprot ID:STK6_HUMAN
Synonyms:
Aurora kinase A
Aurora-A
Aurora-related kinase 1
Aurora/IPL1-related kinase 1
Breast tumor-amplified kinase
hARK1
Serine/threonine kinase 15
Serine/threonine-protein kinase 6
EC-Numbers:2.7.11.1
Organism:Homo sapiens
Human
PDB IDs:1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6
Structure:
3HA6

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
->10000--

References: